Extracellular-Superoxide Dismutase Type C (EC-SOD C) Reduces Myocardial Damage in Rats Subjected to Coronary Occlusion and 24 Hours of Reperfusion

Superoxide Dismutase

1969 • 12,578 citations

The American Journal of Physiology

1899 • 5,863 citations

CRC handbook of methods for oxygen radical research

1985 • 1,496 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Human copper-containing superoxide dismutase of high molecular weight.

1982 • 751 citations

Xanthine oxidase and neutrophil infiltration in intestinal ischemia

1986 • 722 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

The Canadian Journal of Cardiology.

2012 • 587 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

Superoxide mediates reperfusion-induced leukocyte-endothelial cell interactions

1989 • 215 citations

The role of the neutrophil and free radicals in ischemic myocardial injury

1989 • 214 citations

"Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow.

1989 • 209 citations

Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production

1987 • 205 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Therapeutic Approaches to Myocardial Infarct Size Limitation

1985 • 161 citations

Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1990 • 157 citations

Expression of human extracellular superoxide dismutase in Chinese hamster ovary cells and characterization of the product.

1987 • 138 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs.

1988 • 112 citations

Evidence of direct toxic effects of free radicals on the myocardium

1988 • 105 citations

Can superoxide dismutase alter myocardial infarct size?

1989 • 105 citations

Plasma clearance of human extracellular-superoxide dismutase C in rabbits.

1988 • 104 citations

Superoxide dismutase enhances recovery following myocardial ischemia

1985 • 98 citations

The role of xanthine oxidase during myocardial ischemia in several species including man

1988 • 93 citations

Preservation of ischemic myocardium by a new converting enzyme inhibitor, enalaprilic acid, in acute myocardial infarction

1985 • 90 citations

Sustained Limitation by Superoxide Dismutase of Canine Myocardial Injury Due to Regional Ischemia Followed by Reperfusion

1988 • 76 citations

Binding of human extracellular-superoxide dismutase C to cultured cell lines and to blood cells.

1989 • 75 citations

Smooth muscle energetics and theories of cross-bridge regulation

1990 • 73 citations

Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables

1987 • 54 citations

Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs.

1990 • 44 citations

Tissue Distribution of ¹²⁵I‐Labelled Bovine Superoxide Dismutase (SOD) in the Rat

1988 • 40 citations

Fluorescent microspheres: a new tool for visualization of ischemic myocardium in rats

1986 • 39 citations

Superoxide dismutase as an inhibitor of postischemic microvascular permeability increase in the hamster

1990 • 38 citations

Effect of human recombinant superoxide dismutase on canine myocardial infarction

1990 • 36 citations

Beneficial Effects of Coronary Venous Retroinfusion of Superoxide Dismutase and Catalase on Reperfusion Arrhythmias, Myocardial Function, and Infarct Size in Dogs

1989 • 35 citations

Endothelium bound extracellular superoxide dismutase type C reduces damage in reperfused ischaemic rat hearts

1992 • 30 citations

Superoxide dismutase: Possible therapeutic use in cardiovascular disease

1989 • 29 citations

Cardioprotective Effects of Recombinant Human Extracellular-Superoxide Dismutase Type C in Rat Isolated Heart Subjected to Ischemia and Reperfusion

1991 • 29 citations

Effect of superoxide dismutase plus catalase on myocardial infarct size in rabbits.

1988 • 29 citations

Recombinant human extracellular superoxide dismutase reduces concentration of oxygen free radicals in the reperfused rat heart

1990 • 27 citations

Cardioprotective actions of human superoxide dismutase in two reperfusion models of myocardial ischaemia in the rat

1988 • 16 citations

The link between free radicals and myocardial injury.

1988 • 15 citations