Whither biliary sludge?

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Clofibrate and Niacin in Coronary Heart Disease

1975 • 1,660 citations

Harrison's Principles of Internal Medicine.

1984 • 1,638 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Gels

1981 • 875 citations

Lipid Digestion and Absorption

1983 • 859 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.

1978 • 692 citations

Nutritional and hormonal factors influencing desaturation of essential fatty acids

1981 • 557 citations

Mechanisms and consequences of cellular cholesterol exchange and transfer

1987 • 547 citations

A population study on the prevalence of gallstone disease: The sirmione study

1987 • 547 citations

How LDL Receptors Influence Cholesterol and Atherosclerosis

1984 • 516 citations

Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions

1980 • 513 citations

Crystal Growth in Gels

1971 • 417 citations

Effects of obesity and caloric intake on biliary lipid metabolism in man.

1975 • 389 citations

Role of Gallbladder Mucus Hypersecretion in the Evolution of Cholesterol Gallstones

1981 • 374 citations

Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity.

1977 • 347 citations

Phospholipase A2: Function and pharmacological regulation

1987 • 347 citations

The liver: Biology and pathobiology

1988 • 312 citations

Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia

1972 • 308 citations

Influence of Age on Secretion of Cholesterol and Synthesis of Bile Acids by the Liver

1985 • 265 citations

Increased Prevalence of Cholelithiasis in Men Ingesting a Serum-Cholesterol-Lowering Diet

1973 • 241 citations

Aspirin Prevention of Cholesterol Gallstone Formation in Prairie Dogs

1981 • 240 citations

Abnormal gallbladder emptying in a subgroup of patients with gallstones

1985 • 235 citations

Human gallbladder mucin accelerates nucleation of cholesterol in artificial bile

1984 • 230 citations

Origin and fate of biliary sludge

1988 • 224 citations

Aggregation and fusion of phospholipid vesicles

1983 • 214 citations

Quasi-elastic light-scattering studies of aqueous biliary lipid systems. Cholesterol solubilization and precipitation in model bile solutions

1983 • 212 citations

Cholesterol-phosphatidylcholine interactions in multilamellar vesicles

1980 • 211 citations

Biliary proteins. Unique inhibitors of cholesterol crystal nucleation in human gallbladder bile.

1984 • 210 citations

ORAL CONTRACEPTIVES AND VENOUS THROMBOEMBOLIC DISEASE, SURGICALLY CONFIRMED GALLBLADDER DISEASE, AND BREAST TUMOURS

1973 • 205 citations

Nature and Composition of Biliary Sludge

1986 • 205 citations

Control of polyunsaturated acids in tissue lipids.

1986 • 204 citations

A non‐micellar mode of cholesterol transport in human bile

1983 • 204 citations

PREVALENCE OF GALLSTONE DISEASE IN AN ITALIAN ADULT FEMALE POPULATION

1984 • 200 citations

Boston Collaborative Drug Surveillance Program

1978 • 194 citations

Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol gallstones

1983 • 189 citations

Effects of Clofibrate and of an Estrogen-Progestin Combination on Fasting Biliary Lipids and Cholic Acid Kinetics in Man

1974 • 179 citations

Intestinal transit, deoxycholic acid and the cholesterol saturation of bile--three inter-related factors.

1986 • 172 citations

Factors affecting cholesterol monohydrate crystal nucleation time in model systems of supersaturated bile.

1985 • 168 citations

Abnormal gallbladder emptying in patients with gallstones

1982 • 164 citations

Rapid vesicle formation and aggregation in abnormal human biles

1986 • 155 citations

The Liver

1989 • 143 citations

The role of the gallbladder in the pathogenesis of cholesterol gallstones

1979 • 139 citations

Effect of vegetarianism on development of gall stones in women.

1985 • 138 citations

Defective gallbladder contractility in the ground squirrel and prairie dog during the early stages of cholesterol gallstone formation

1983 • 138 citations

Human gallbladder mucin binds biliary lipids and promotes cholesterol crystal nucleation in model bile

1987 • 136 citations

Electron microscopy of the intestine and rectum in acquired immunodeficiency syndrome

1985 • 134 citations

Vesicle aggregation in model systems of supersaturated bile: relation to crystal nucleation and lipid composition of the vesicular phase.

1987 • 133 citations

Influence of gallstones and ursodeoxycholic acid therapy on gallbladder emptying

1984 • 133 citations

The Anatomy of Gallstones

1963 • 128 citations

ALIMENTARY PRODUCTION OF GALLSTONES IN HAMSTERS*

1952 • 126 citations

On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs

1977 • 125 citations

Sludge is calcium bilirubinate associated with bile stasis

1981 • 125 citations

Impaired Gallbladder Emptying Before Gallstone Formation in the Prairie Dog

1983 • 120 citations

Rat‐Liver Acyl‐CoA: Cholesterol Acyltransferase

1978 • 118 citations

Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification.

1984 • 116 citations

Frequency of Gallstone Disease in a Well-Defined Swedish Population

1977 • 116 citations

Studies on Membrane Fusion with Natural and Model Membranes

1979 • 116 citations

When The Eskimo Comes To Town

1971 • 116 citations

Properties of acyl-CoA:cholesterol acyltransferase in rat liver microsomes. Topological localization and effects of detergents, albumin, and polar steroids.

1980 • 114 citations

Deoxycholic acid and the pathogenesis of gall stones.

1988 • 114 citations

Hydrophobic binding properties of bovine gallbladder mucin.

1984 • 111 citations

Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species

1986 • 110 citations

Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics

1982 • 110 citations

Pretreatment Biliary Lipid Composition in White Patients with Radiol0ucent Gallstones in the National Cooperative Gallstone Study

1982 • 110 citations

Effects of acute changes of bile acid pool composition on biliary lipid secretion.

1984 • 107 citations

The stability and structure of cholesterol-rich codispersions of cholesterol and phosphatidylcholine.

1982 • 107 citations

Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix. Effects of reducing agents on in vitro dissolution of matrix and intact gallstones.

1985 • 105 citations

Biliary lipid outputs in young women with cholesterol gallstones

1974 • 103 citations

Biliary Proteins and the Nucleation Defect in Cholesterol Cholelithiasis

1987 • 101 citations

Role of Gallbladder Mucin in Pathophysiology of Gallstones

1984 • 101 citations

Differences in the effects of chenodeoxycholic and ursodeoxycholic acid on biliary lipid secretion and bile acid synthesis in patients with gallstones

1984 • 97 citations

Solubilisation of cholesterol in human bile

1985 • 87 citations

The submicrosomal localization of acyl-coenzyme A–cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver

1978 • 85 citations

Arachidonic acid stimulates mucin secretion in prairie dog gallbladder

1983 • 80 citations

Abnormal polyunsaturated fatty acid patterns of serum lipids in alcoholism and cirrhosis: arachidonic acid deficiency in cirrhosis.

1985 • 79 citations

Functional Activities of Hepatic Lipoprotein Receptors

1986 • 76 citations

Gallbladder prostaglandins and lysophospholipids as mediators of mucin secretion during cholelithiasis

1986 • 75 citations

Primate Biliary Physiology

1973 • 74 citations

The composition and polymeric structure of mucus glycoprotein from human gallbladder bile

1982 • 73 citations

Cholesterol desorption from clusters of phosphatidylcholine and cholesterol in unilamellar vesicle bilayers during lipid transfer or exchange

1982 • 73 citations

Studies on human bile

1971 • 73 citations

CLOFIBRATE AND GALLSTONES

1975 • 72 citations

Biliary lipid output and bile acid kinetics in cholesterol gallstone disease

1985 • 72 citations

Partial characterization of a nonmicellar system of cholesterol solubilization in bile

1987 • 71 citations

Contraceptive steroids increase hepatic uptake of chylomicron remnants in healthy young women.

1988 • 70 citations

The Effect of Progesterone on the Regulatory Mechanisms of Biliary Cholesterol Secretion in the Rat

2007 • 70 citations

Absorption of lecithin and lysolecithin by the gallbladder.

1973 • 69 citations

Development of Lithogenic Bile during Puberty in Pima Indians

1979 • 68 citations

Cholesterol-phospholipid vesicles in human bile: an ultrastructural study

1986 • 68 citations

Effects of cholesterol on acyl chain dynamics in multilamellar vesicles of various phosphatidylcholines

1983 • 68 citations

Fatty acid composition of phospholipids in bile in man: Promoting effect of deoxycholate on arachidonate

1987 • 68 citations

Role of gallbladder mucus in the pathogenesis of cholesterol gallstones

1983 • 67 citations

Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis

1981 • 67 citations

Properties of a solubilised and reconstituted preparation of ACYL-CoA:cholesterol acyltransferase from rat liver

1982 • 67 citations

Bovine gallbladder mucin binds bilirubin in vitro

1983 • 65 citations

Physicochemical Properties of Prostaglandin F2α (Tromethamine Salt): Solubility Behavior, Surface Properties, and Ionization Constants

1973 • 65 citations

Simulation of the metabolism and enterohepatic circulation of endogenous deoxycholic acid in humans using a physiologic pharmacokinetic model for bile acid metabolism

1987 • 64 citations

Outcome of Chenodeoxycholic Acid (CDCA) Treatment in 125 Patients with Radiolucent Gallstones

1982 • 64 citations

Distribution of biliary cholesterol between mixed micelles and nonmicelles in relation to fasting and feeding in humans

1986 • 63 citations

Effect of gemfibrozil on biliary lipid metabolism in normolipemic subjects

1985 • 60 citations

Contraceptive steroids increase cholesterol in bile: mechanisms of action.

1987 • 56 citations

Studies on human bile

1971 • 54 citations

Molecular species of biliary phosphatidylcholines in gallstone patients: the influence of treatment with cholic acid and chenodeoxycholic acid

1981 • 53 citations

Biliary Proteins

1984 • 51 citations

Biliary lipid secretion in patients with heterozygous familial hypercholesterolemia and combined hyperlipidemia. Influence of bezafibrate and fenofibrate.

1988 • 51 citations

The process of cholesterol cholelithiasis induced by diet in the prairie dog: a physicochemical characterization.

1976 • 50 citations

Studies on Human Bile II: Influence of two different fats on the composition of human bile

1967 • 49 citations

Increases in gallbladder prostaglandin synthesis before the formation of cholesterol gallstones.

1985 • 49 citations

The evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid diet.

1982 • 49 citations

Recent progress in understanding cholesterol crystal nucleation as a precursor to human gallstone formation

1986 • 48 citations

Hydrolysis of chylomicron arachidonate and linoleate ester bonds by lipoprotein lipase and hepatic lipase

1987 • 45 citations

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

1979 • 44 citations

Acyl-coenzyme A:Cholesterol acyltransferase in human liver. In vitro detection and some characteristics of the enzyme

1980 • 44 citations

Liquid crystals and cholesterol nucleation during equilibration in supersaturated bile analogs

1978 • 42 citations

Structure of biliary phosphatidylcholine in cholesterol gallstone patients

1981 • 41 citations

Interaction of intestinal brush border membrane vesicles with small unilamellar phospholipid vesicles. Exchange of lipids between membranes is mediated by collisional contact

1986 • 39 citations

Stasis before gallstone formation: Altered gallbladder compliance or cystic duct resistance?

1982 • 36 citations

Evidence that a diminished bile acid pool precedes the formation of cholesterol gallstones in man.

1973 • 36 citations

Effects of Indomethacin on Prostaglandin Synthesis and on Contractile Response of the Guinea Pig Gallbladder

1981 • 34 citations

Effect of prostaglandins E1, E2 and F2α, and pentagstrin on the gall bladder pressure in dogs

1975 • 34 citations

Prostaglandins and leukotrienes

1985 • 33 citations

Gallbladder contractility and mucus secretion after cholesterol feeding in the prairie dog.

1986 • 33 citations

Effect of synthetic oestrogens and progestagens in oral contraceptives on bile lipid composition.

1983 • 31 citations

Peptides Recognizing Calmodulin

1986 • 31 citations

Effects of Prostaglandins on Motility of Gallbladders Removed From Patients With Gallstones

1984 • 31 citations

Prevalence of cholelithiasis in men and women ingesting a serum-cholesterol-lowering diet.

1976 • 31 citations

Metabolism of individual molecular species of phosphatidylcholine in the liver subcellular membranes and bile origin of bile phosphatidylcholine

1980 • 30 citations

Biliary cholesterol saturation in non‐obese women and non‐obese men before and after puberty

1986 • 29 citations

Secretion of biliary lipids in young Chilean women with cholesterol gallstones.

1979 • 28 citations

The effect of lysophosphatidylcholine on gallbladder function in the cat.

1983 • 26 citations

Factors Influencing Cholesterol Nucleation in Bile

1984 • 26 citations

Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver

1986 • 25 citations

Dietary Factors Affecting Biliary Lipid Secretion in the Rhesus Monkey A Mechanism for the Hypocholesterolaemic Action of Polyunsaturated Fat?*

1972 • 25 citations

Biliary Lipid Output and Bile Acid Kinetics in Cholesterol Gallstone Disease

1985 • 25 citations

Hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in hamsters on a lithogenic diet.

1977 • 24 citations

Lipid metabolism in the development of cholesterol gallstones in hamsters. I. Study on the relationship between serum and biliary lipids.

1980 • 18 citations

A Model for Gallbladder Function and Cholesterol Gallstone Formation

1970 • 17 citations

Hepatic cholesterogenesis in Chileans with cholesterol gallstone disease

1981 • 17 citations

Cholesterol 7α-Hydroxylase (7α-Monooxygenase)

1986 • 17 citations

Role of Hepatic Cholesterol Esterification

1984 • 17 citations

Effect of estrogen on rabbit gallbladder prostaglandin biosynthesis

1985 • 14 citations

Silicone Polymer Uptake Method for Determination of Cholesterol Thermodynamic Activity in Model Bile Systems

1988 • 13 citations

Hepatic Chylomicron Remnant (Apolipoprotein E) Receptors: Their Physiologic and Clinical Importance

1987 • 11 citations

The crystal growth in gels

1980 • 11 citations

The enterohepatic circulation of bile acids during continuous liquid formula perfusion of the duodenum.

1983 • 10 citations

Short-term diabetes increases triacylglycerol arachidonic acid content in the rat liver

1987 • 10 citations

Hydrocortisone inhibits mucin secretion from guinea pig gallbladder

1984 • 10 citations

Lysophosphatidylcholine acyltransferases activity during experimental cholelithiasis

1981 • 9 citations

Transport, utilization and biliary secretion of lysophosphatidylcholine in the rat liver

1987 • 9 citations

Effects of lysophosphatidylcholine on jejunal water and solute transport in the rat in vivo

1983 • 8 citations

Physicochemical Factors Underlying Lipid Membrane Fusion

1987 • 7 citations

The role of phospholipase A in gallstone formation

1974 • 6 citations

Biosynthesis of bile acids

1968 • 6 citations

The effect of prosthetic gallstones on total bile acid pool size in dogs.

1978 • 4 citations

Bile Acids in Health and Disease: Update on Cholesterol Gallstones and Bile Acid Diarrhoea

1988 • 4 citations