Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated Adenomas

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer

2000 • 1,821 citations

Colorectal cancer screening: Clinical guidelines and rationale

1997 • 1,546 citations

Colorectal cancer screening: Clinical guidelines and rationale

1997 • 1,534 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Risk of Advanced Proximal Neoplasms in Asymptomatic Adults According to the Distal Colorectal Findings

2000 • 1,082 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Mixed Hyperplastic Adenomatous Polyps/Serrated Adenomas

1990 • 667 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Morphology of sporadic colorectal cancer with DNA replication errors

1998 • 465 citations

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer

1996 • 451 citations

Microsatellite instability and the clinicopathological features of sporadic colorectal cancer

2001 • 372 citations

DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

1999 • 338 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

2000 • 255 citations

Alternative genetic pathways in colorectal carcinogenesis

1997 • 251 citations

Phenotypic and molecular characteristics of hyperplastic polyposis

2000 • 217 citations

Accumulated Clonal Genetic Alterations in Familial and Sporadic Colorectal Carcinomas with Widespread Instability in Microsatellite Sequences

1998 • 190 citations

Microsatellite instability: The mutator that mutates the other mutator

1996 • 176 citations

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

2000 • 151 citations

High frequency of K-ras mutations in human colorectal hyperplastic polyps.

1997 • 148 citations

Predictors of presence, multiplicity, size and dysplasia of colorectal adenomas. A necropsy study in New Zealand.

1992 • 139 citations

A case-control study of dietary intake and other lifestyle risk factors for hyperplastic polyps

1997 • 112 citations

Deletion of 1p loci and microsatellite instability in colorectal polyps

1995 • 98 citations

Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer

1995 • 94 citations

Genetic epidemiology of mutated K-rasproto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas

1999 • 76 citations

Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum

1998 • 75 citations

Microsatellite instability in colorectal adenomas

1997 • 64 citations

Colorectal Carcinomas Arising in the Hyperplastic Polyposis Syndrome Progress through the Chromosomal Instability Pathway

2000 • 63 citations

Colorectal adenomas in surgical specimens from subjects with hereditary non‐polyposis colorectal cancer

1995 • 44 citations