Compensation by tumor suppressor genes during retinal development in mice and humans

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Translating developmental time across mammalian species

2001 • 1,182 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells

2001 • 917 citations

Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation

1997 • 882 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Induction of medulloblastomas inp53-null mutant mice by somatic inactivation ofRbin the external granular layer cells of the cerebellum

2000 • 817 citations

Genomic Analysis of Mouse Retinal Development

2004 • 584 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

Retinopathy and attenuated circadian entrainment in Crx-deficient mice

1999 • 512 citations

Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation

1996 • 506 citations

Control of Müller glial cell proliferation and activation following retinal injury

2000 • 426 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina

2003 • 399 citations

Extra-embryonic function of Rb is essential for embryonic development and viability

2003 • 383 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

1998 • 316 citations

Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter

2004 • 303 citations

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

2004 • 277 citations

Glial cell fate specification modulated by the bHLH gene Hes5in mouse retina

2000 • 269 citations

Math3andNeuroDregulate amacrine cell fate specification in the retina

2002 • 258 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Regulating proliferation during retinal development

2001 • 236 citations

p27^Kip1and p57^Kip2Regulate Proliferation in Distinct Retinal Progenitor Cell Populations

2001 • 226 citations

Cell type-specific effects of Rb deletion in the murine retina

2004 • 217 citations

Quantitative analysis of proliferation and cell cycle length during development of the rat retina

1996 • 200 citations

Rb regulates proliferation and rod photoreceptor development in the mouse retina

2004 • 188 citations

p57Kip2 regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina

2000 • 187 citations

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

2004 • 174 citations

The search for the retinoblastoma cell of origin

2005 • 169 citations

p27Kip1 Regulates Cell Cycle Withdrawal of Late Multipotent Progenitor Cells in the Mammalian Retina

2000 • 167 citations

Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny

1997 • 165 citations

The First Knockout Mouse Model of Retinoblastoma

2004 • 160 citations

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

2004 • 137 citations

Regulation of proliferation, cell fate specification and differentiation by the homeodomain proteins Prox1, Six3, and Chx10 in the developing retina.

2003 • 78 citations

Regulation of proliferation during central nervous system development

2005 • 72 citations

The Homeodomain Proteins Prox1, Six3 and Chx10 Regulate Proliferation, Cell Fate Specification and Differentiation in the Developing Retina

2003 • 68 citations

Mouse models of childhood cancer of the nervous system

2004 • 58 citations

The p57Kip2 cyclin kinase inhibitor is expressed by a restricted set of amacrine cells in the rodent retina

2000 • 46 citations

Developmental defects in Rb-deficient retinae

2004 • 35 citations

An E2F Binding-Deficient Rb1 Protein Partially Rescues Developmental Defects Associated with Rb1 Nullizygosity

2006 • 34 citations

Distinct patterns of expression of the RB gene family in mouse and human retina

2005 • 26 citations

Perspective: New genetic tools for studying retinal development and disease

2005 • 11 citations