Snake venom proteases affecting hemostasis and thrombosis

Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis

1996 • 893 citations

Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion

1996 • 785 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Snake venoms and the hemostatic system

1998 • 681 citations

Diet and snake venom evolution

1996 • 644 citations

Factor X activating enzyme from Russell's viper venom: isolation and characterization

1976 • 387 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

[21] Snake venom metalloendopeptidases: Reprolysins

1995 • 278 citations

cDNA Sequences for Four Snake Venom Metalloproteinases: Structure, Classification, and Their Relationship to Mammalian Reproductive Proteins

1994 • 239 citations

Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases

1996 • 225 citations

Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.

1992 • 222 citations

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

1993 • 215 citations

Viper Venom Disintegrins and Related Molecules

1998 • 189 citations

Mocarhagin, a Novel Cobra Venom Metalloproteinase, Cleaves the Platelet von Willebrand Factor Receptor Glycoprotein Ibα. Identification of the Sulfated Tyrosine/Anionic Sequence Tyr-276−Glu-282 of Glycoprotein Ibα as a Binding Site for von Willebrand Factor and α-Thrombin

1996 • 185 citations

The clot thickens: clues provided by thrombin structure

1995 • 177 citations

A Novel Plasminogen Activator from Snake Venom

1995 • 170 citations

Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (Western Diamondback Rattlesnake)

1984 • 159 citations

Molecular cloning and sequence analysis of cDNA for batroxobin, a thrombin-like snake venom enzyme.

1987 • 155 citations

Isolation and Characterization of Carinactivase, a Novel Prothrombin Activator in Echis carinatus Venom with a Unique Catalytic Mechanism

1996 • 150 citations

A 28-kDa Protein with Disintegrin-like Structure (Jararhagin-C) Purified from Bothrops jararaca Venom Inhibits Collagen- and ADP-Induced Platelet Aggregation

1994 • 142 citations

Function of Disintegrin-like/Cysteine-rich Domains of Atrolysin A

1997 • 141 citations

Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).

1994 • 130 citations

Thrombin-like Enzymes from Snake Venoms: An Updated Inventory

1998 • 122 citations

Activation of snake venom metalloproteinases by a cysteine switch‐like mechanism

1993 • 118 citations

Purification and Characterization of Bothrombin, a Fibrinogen-Clotting Serine Protease from the Venom of Bothrops jararaca

1994 • 114 citations

The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences.

1988 • 114 citations

Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus

1998 • 114 citations

Snake Venom Fibrinogenolytic and Fibrinolytic Enzymes: An Updated Inventory

1998 • 112 citations

The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases

1998 • 108 citations

cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom

1995 • 105 citations

Purification, Characterization, and Amino Acid Sequence of a Serine Proteinase, PA-BJ, with Platelet-Aggregating Activity from the Venom of Bothrops jararaca

1995 • 102 citations

Coagulation studies on „Reptilase”, an extract of the venom from Bothrops jararaca

1957 • 98 citations

Characterization of bovine prothrombin mRNA and its translation product

1984 • 94 citations

A Peptide Inhibiting the Collagen Binding Function of Integrin α2I Domain

1999 • 94 citations

Kallikrein-like enzymes from Crotalus atrox venom.

1983 • 93 citations

Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina (snake) venom

1991 • 93 citations

Amino acid sequence of fibrolase, a direct‐acting fibrinolytic enzyme from agkistrodon contortrix contortrix venom

1992 • 92 citations

Amino acid sequence determination of Ancrod, the thrombin‐like α‐fibrinogenase from the venom of Akistrodon rhodostoma

1992 • 82 citations

Characterization of a protein C activator from Agkistrodon contortrix contortrix venom.

1987 • 80 citations

Inventory of α- and β-Fibrinogenases from Snake Venoms

1991 • 79 citations

Amino Acid Sequence of a Coagulant Enzyme, Flavoxobin, from Trimeresurus flavoviridis Venom1

1988 • 76 citations

Overview of Snake Venom Chemistry

1996 • 76 citations

Thrombin and Antithrombotics

1998 • 72 citations

The Primary Structure of Porcine Glandular Kallikreins

1979 • 71 citations

Inventory of alpha- and beta-fibrinogenases from snake venoms. For the Subcommittee on Nomenclature of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.

1991 • 70 citations

Crystal Structure of H2-Proteinase from the Venom of Trimeresurus flavoviridis

1996 • 67 citations

Purification and Characterization of Kaouthiagin, a von Willebrand Factor-Binding and -Cleaving Metalloproteinase from Naja kaouthia Cobra Venom

1998 • 67 citations

Molecular cloning and sequence analysis of the cDNA for ancrod, a thrombin-like enzyme from the venom of Calloselasma rhodostoma

1993 • 66 citations

Studies on the coagulant enzyme from Agkistrodon rhodostoma venom. Isolation and some properties of the enzyme

1973 • 66 citations

Complete primary structure and biochemical properties of gilatoxin, a serine protease with kallikrein-like and angiotensin-degrading activities.

1993 • 59 citations

Thrombin-Like Enzymes from Snake Venoms: An Inventory

1991 • 55 citations

Identification of the Cleavage Sites by a Hemorrhagic Metalloproteinase in Type IV Collagen

1990 • 52 citations

The complete amino acid sequence of a thrombin‐like enzyme/gyroxin analogue from venom of the bushmaster snake (Lachesis muta muta)

1993 • 52 citations

Primary Structure of a Coagulant Enzyme, Bilineobin, from Agkistrodon bilineatus Venom

1995 • 50 citations

Purification and amino acid sequence of halystase from snake venom of Agkistrodon halys blomhoffii, a serine protease that cleaves specifically fibrinogen and kininogen

1998 • 48 citations

Characterization of One Novel Venom Protease with β-Fibrinogenase Activity from the Taiwan Habu (Trimeresurus mucrosquamatus): Purification and cDNA Sequence Analysis

1994 • 45 citations

The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites

1998 • 41 citations

Characterization of mocarhagin, a cobra venom metalloproteinase from Naja mocambique mocambique, and related proteins from other Elapidae venoms

1996 • 32 citations

Characterization of Snake Venom Principles Affecting Blood Coagulation and Platelet Aggregation

1990 • 31 citations

Crotalase, a Fibrinogen-Clotting Snake Venom Enzyme: Primary Structure and Evidence for a Fibrinogen Recognition Exosite Different from Thrombin

1999 • 31 citations

Biochemical characterization of atroxase and nucleotide sequence encoding the fibrinolytic enzyme

1996 • 30 citations

Inventory of Haemorrhagic Factors from Snake Venoms

1994 • 30 citations

[24] Snake venom hemorrhagic and nonhemorrhagic metalloendopeptidases

1993 • 27 citations

[37] Proteinases from the venom of Agkistrodon halys blomhoffii

1976 • 21 citations

Use of snake venom fractions in the coagulation laboratory

1998 • 21 citations

Thrombin-Like Venom Enzymes: Structure and Function

1990 • 20 citations

Structure and Function of Snake Venom Metalloproteinase Family

1993 • 6 citations