Three-Dimensional Solution Structure of Escherichia coli Periplasmic Cyclophilin

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy

1985 • 3,603 citations

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1983 • 3,150 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy

1983 • 2,638 citations

Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy

1980 • 2,519 citations

A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

1980 • 1,886 citations

Multiple quantum filters for elucidating NMR coupling networks

1982 • 1,780 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins

1989 • 1,395 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Pseudo-structures for the 20 common amino acids for use in studies of protein conformations by measurements of intramolecular proton-proton distance constraints with nuclear magnetic resonance

1983 • 1,012 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Quantitative J correlation: a new approach for measuring homonuclear three-bond J(HNH.alpha.) coupling constants in 15N-enriched proteins

1993 • 975 citations

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1991 • 882 citations

Overcoming the overlap problem in the assignment of proton NMR spectra of larger proteins by use of three-dimensional heteronuclear proton-nitrogen-15 Hartmann-Hahn-multiple quantum coherence and nuclear Overhauser-multiple quantum coherence spectroscopy: application to interleukin 1.beta.

1989 • 840 citations

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1993 • 802 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Sequential resonance assignments in protein 1H nuclear magnetic resonance spectra

1982 • 585 citations

1H1H correlation via isotropic mixing of 13C magnetization, a new three-dimensional approach for assigning 1H and 13C spectra of 13C-enriched proteins

1990 • 580 citations

Protein structures in solution by nuclear magnetic resonance and distance geometry

1987 • 569 citations

Catalysis of protein folding by prolyl isomerase

1987 • 488 citations

An evaluation of computational strategies for use in the determination of protein structure from distance constraints obtained by nuclear magnetic resonance

1991 • 426 citations

Heteronuclear three-dimensional nmr spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra

1988 • 382 citations

Simplification of NMR spectra by filtration through multiple-quantum coherence

1983 • 349 citations

The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures

1992 • 328 citations

Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a

1989 • 324 citations

Isolation and amino acid sequence of cyclophilin.

1986 • 294 citations

Active site mutants of human cyclophilin A separate peptidyl‐prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

1992 • 287 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

An alternative 3D NMR technique for correlating backbone 15N with side chain Hβ resonances in larger proteins

1991 • 273 citations

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

1991 • 270 citations

NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

1991 • 268 citations

Solution structure of the cyclosporin A/cyclophilin complex by NMR

1993 • 241 citations

Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

1990 • 237 citations

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

1993 • 217 citations

Three-dimensional NOESY-HMQC spectroscopy of a 13C-labeled protein

1990 • 212 citations

Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase

1992 • 206 citations

Practical aspects of proton-carbon-carbon-proton three-dimensional correlation spectroscopy of 13C-labeled proteins

1990 • 200 citations

NMR studies of [U-13C] cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding

1991 • 194 citations

Proton-proton correlation via carbon-carbon couplings: a three-dimensional NMR approach for the assignment of aliphatic resonances in proteins labeled with carbon-13

1990 • 189 citations

Stereospecific assignments of side‐chain protons and characterization of torsion angles in Eglin c

1987 • 187 citations

Catalysis of protein folding by cyclophilins from different species

1991 • 183 citations

Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

1991 • 169 citations

Complete resonance assignment for the polypeptide backbone of interleukin 1.beta. using three-dimensional heteronuclear NMR spectroscopy

1990 • 168 citations

2D and 3D NMR spectroscopy employing carbon-13/carbon-13 magnetization transfer by isotropic mixing. Spin system identification in large proteins

1990 • 168 citations

Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum

1991 • 168 citations

Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion

1990 • 164 citations

Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells

1991 • 159 citations

Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue

1991 • 153 citations

Folding of ribonuclease T1. 2. Kinetic models for the folding and unfolding reactions

1990 • 141 citations

The X‐ray structure of a tetrapeptide bound to the active site of human cyclophilin A

1992 • 129 citations

Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.

1992 • 126 citations

A new method for building protein conformations from sequence alignments with homologues of known structure

1991 • 126 citations

Stereospecific assignments of ¹H‐nmr methyl lines and conformation of valyl residues in the lac repressor headpiece

1985 • 120 citations

Similarities and differences between human cyclophilin A and other β-barrel structures

1992 • 112 citations

Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl‐prolyl cis‐trans isomerases

1992 • 111 citations

Stereospecific assignment of β-methylene protons in larger proteins using 3D15N-separated Hartmann-Hahn and13C-separated rotating frame Overhauser spectroscopy

1991 • 105 citations

Cyclosporin A—cyclophilin complex formation A model based on X‐ray and NMR data

1992 • 101 citations

Three-dimensional 13C-resolved proton NOE spectroscopy of uniformly 13C-labeled proteins for the NMR assignment and structure determination of larger molecules

1990 • 97 citations

A composite FKBP12-FK506 surface that contacts calcineurin

1993 • 83 citations

Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization.

1993 • 83 citations

Structural and functional characterization of Escherichia coli peptidyl‐prolyl cis‐trans isomerases

1992 • 81 citations

Genetic dissection of cyclophilin function. Saturation mutagenesis of the Drosophila cyclophilin homolog ninaA.

1992 • 70 citations

Protein secondary structure determination by NMR Application with recombinant human cyclophilin

1991 • 66 citations

A model of the cyclophilin/cyclosporin A (CSA) complex from NMR and X-ray data suggests that CSA binds as a transition-state analog

1992 • 52 citations

Solution structure of cyclosporin A and a nonimmunosuppressive analog bound to fully deuterated cyclophilin

1992 • 47 citations

The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin

1993 • 39 citations

¹H,¹³C and ¹⁵N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site

1991 • 29 citations

Secondary structure and backbone resonance assignments of the periplasmic cyclophilin type peptidyl-prolyl isomerase from Escherichia coli

1993 • 12 citations