TH-17 cells in rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1999 • 1,660 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

2006 • 947 citations

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1999 • 943 citations

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

2008 • 897 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

2005 • 506 citations

Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.

1985 • 462 citations

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.

2005 • 378 citations

Distinct regulation of interleukin‐17 in human T helper lymphocytes

2007 • 353 citations

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes

2007 • 248 citations

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis

2007 • 245 citations

Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis

1997 • 210 citations

Increased macrophage activation mediated through toll‐like receptors in rheumatoid arthritis

2007 • 185 citations

Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF- B- and p38 MAPK-dependent signalling pathways

2006 • 164 citations

IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis

2008 • 160 citations

Interleukin 27 attenuates collagen-induced arthritis

2008 • 147 citations

Interleukin‐17 in fashion, at last: Ten years after its description, its cellular source has been identified

2007 • 121 citations

Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue

2002 • 107 citations

Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis

2008 • 89 citations

Interleukin (IL)-23 p19 expression induced by IL-1 in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor- B and AP-1 dependent pathway

2007 • 81 citations

Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis

2007 • 67 citations

The clinical role of IL‐23p19 in patients with rheumatoid arthritis

2007 • 67 citations

Expression and function of CD5 and CD28 in patients with rheumatoid arthritis.

1993 • 15 citations