Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia

Angiogenesis in health and disease

2003 • 4,127 citations

Mechanisms of angiogenesis and arteriogenesis

2000 • 4,120 citations

Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration

2002 • 587 citations

Angiogenic Gene Therapy (AGENT) Trial in Patients With Stable Angina Pectoris

2002 • 524 citations

Phase 1/2 Placebo-Controlled, Double-Blind, Dose-Escalating Trial of Myocardial Vascular Endothelial Growth Factor 2 Gene Transfer by Catheter Delivery in Patients With Chronic Myocardial Ischemia

2002 • 473 citations

Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus

2000 • 470 citations

Local Delivery of Plasmid DNA Into Rat Carotid Artery Using Ultrasound

2002 • 466 citations

Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle

2002 • 395 citations

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy

2002 • 389 citations

PR39, a peptide regulator of angiogenesis

2000 • 383 citations

Increased Vascularity Detected by Digital Subtraction Angiography after VEGF Gene Transfer to Human Lower Limb Artery: A Randomized, Placebo-Controlled, Double-Blinded Phase II Study

2002 • 370 citations

Microbubble-enhanced ultrasound for vascular gene delivery

2000 • 337 citations

Left Ventricular Electromechanical Mapping to Assess Efficacy of phVEGF ₁₆₅ Gene Transfer for Therapeutic Angiogenesis in Chronic Myocardial Ischemia

2000 • 329 citations

Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor

2000 • 321 citations

Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia

2001 • 316 citations

Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets

2000 • 234 citations

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease

2001 • 226 citations

Cell Transplantation for the Treatment of Acute Myocardial Infarction Using Vascular Endothelial Growth Factor–Expressing Skeletal Myoblasts

2001 • 223 citations

Phase Behavior, DNA Ordering, and Size Instability of Cationic Lipoplexes

2001 • 189 citations

Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat

2002 • 185 citations

Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor

2000 • 177 citations

Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart

2000 • 164 citations

Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein

2002 • 156 citations

Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121 1 1Ronald G. Crystal and Todd K. Rosengart contributed equally as senior investigators in this study.

2000 • 148 citations

Fibroblast Growth Factor-2 Gene Transfer Can Stimulate Hepatocyte Growth Factor Expression Irrespective of Hypoxia-Mediated Downregulation in Ischemic Limbs

2002 • 92 citations

An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus

2001 • 90 citations

Recombinant Vascular Endothelial Growth Factor Secreted From Tissue-Engineered Bioartificial Muscles Promotes Localized Angiogenesis

2001 • 86 citations

AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model

2002 • 76 citations

Effects of intramyocardial injection of phVEGF‐A₁₆₅ as sole therapy in patients with refractory coronary artery disease – 12‐month follow‐up: Angiogenic gene therapy

2001 • 75 citations

Inhibition of the Cardiac Angiogenic Response to Surgical FGF-2 Therapy in a Swine Endothelial Dysfunction Model

2003 • 73 citations

Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity

2001 • 65 citations

Gene Transfer for Angiogenesis in Coronary Artery Disease

2001 • 52 citations

Efficient Expression of the Vascular Endothelial Growth Factor Gene In Vitro and In Vivo, Using an Adeno-associated Virus Vector

2001 • 50 citations

Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation

2000 • 46 citations

Improved Adenoviral Vector for Vascular Gene Therapy

2001 • 45 citations

Induction of angiogenesis by cationic lipid-mediated VEGF165 gene transfer in the rabbit ischemic hindlimb model

2000 • 34 citations

Simultaneous surgical revascularization and angiogenic gene therapy in diffuse coronary artery disease

2001 • 22 citations

Angiogenesis in Health and Disease

1999 • 18 citations

Gene transfer to induce angiogenesis in myocardial and limb ischaemia

2001 • 15 citations

Therapeutic angiogenesis for coronary artery disease

2002 • 11 citations

Assessing the Role of Gene Therapy in the Treatment of Vascular Disease

2000 • 10 citations

Bioartificial Muscles in Gene Therapy

2003 • 8 citations

Longevity of the placebo effect in patients enrolled in angiogenesis and laser myocardial revascularization trials

2002 • 5 citations