Diet-induced thermogenesis

Bioenergetics and Growth.

1946 • 3,395 citations

A role for brown adipose tissue in diet-induced thermogenesis

1979 • 1,587 citations

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977

1977 • 935 citations

Brown fat and thermogenesis.

1969 • 696 citations

Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline

1978 • 653 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

NON‐SHIVERING THERMOGENESIS AND ITS THERMOREGULATORY SIGNIFICANCE

1973 • 604 citations

Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes

1976 • 602 citations

The distribution of brown adipose tissue in the human.

1972 • 590 citations

Endocrine and Metabolic Effects of Experimental Obesity in Man

1973 • 554 citations

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

1979 • 509 citations

β-Endorphin Is Associated with Overeating in Genetically Obese Mice ( ob / ob ) and Rats ( fa / fa )

1978 • 474 citations

URGES TO EAT AND DRINK IN RATS

1947 • 444 citations

Brown adipose tissue mitochondria

1979 • 369 citations

Dietary Obesity in Rats: Body Weight and Body Fat Accretion in Seven Strains of Rats

1970 • 349 citations

Effects of Antecedent Food Intake Pattern on Hepatic Lipogenesis

1958 • 343 citations

Sympathetic regulation of metabolism.

1967 • 338 citations

Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat.

1962 • 324 citations

Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus

1981 • 321 citations

Food Intake as a Mechanism of Temperature Regulation*

1997 • 319 citations

Dietary-induced alterations in thyroid hormone metabolism during overnutrition.

1979 • 306 citations

Brown adipose tissue and the response of new‐born rabbits to cold

1964 • 303 citations

Reduced thermogenesis in obesity

1979 • 296 citations

Hamster Brown‐Adipose‐Tissue Mitochondria

1976 • 283 citations

Cellular Thermogenesis

1976 • 274 citations

Weight regulation in normal and hypothalamic hyperphagic rats.

1966 • 257 citations

Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse

1978 • 257 citations

Comparative Nutrition of Man and Domestic Animals

1962 • 256 citations

Gluttony

1967 • 254 citations

THE DEVELOPMENT WITH AGE OF HYPOTHALAMIC RESTRAINT UPON THE APPETITE OF THE RAT

1957 • 246 citations

Long-term energy balance in child-bearing Gambian women

1981 • 245 citations

Mitochondrial protein alteration in active brown fat: A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study

1976 • 244 citations

Die Gesetze des Energieverbrauchs bei der Ernährung

1902 • 244 citations

Effect of caloric restriction and excessive caloric intake on energy expenditure

1971 • 236 citations

Substrate cycles in metabolic regulation and in heat generation.

1976 • 229 citations

Endocrinological aspects of exposure to high environmental temperatures.

1968 • 214 citations

A mitochondrial defect in brown adipose tissue of the obese (obob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding

1978 • 212 citations

Weight Maintenance and Food Intake

1962 • 206 citations

The so‐called hibernating gland

1923 • 202 citations

The Influence of a Hypercaloric Diet on Gross Body and Adipose Tissue Composition in the Rat

1962 • 200 citations

The energy and nutrient intake and the energy expenditure of 204 New Guinean adults

1974 • 199 citations

Gluttony

1967 • 197 citations

Changes in body composition attendant on force feeding

1959 • 185 citations

Regulation of energy balance in two models of reversible obesity in the rat.

1979 • 181 citations

Regional blood flow in genetically obese (ob/ob) mice

1980 • 180 citations

Release of Prostaglandin from Rat Epididymal Fat Pad on Nervous and Hormonal Stimulation

1968 • 176 citations

Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesis

1981 • 166 citations

Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis

1980 • 160 citations

REGULATION OF ENERGY BALANCE

1981 • 155 citations

Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue

1980 • 154 citations

Similarities between cold- and diet-induced thermogenesis in the rat

1980 • 152 citations

Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice

1982 • 149 citations

A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats

1981 • 147 citations

Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia

1980 • 144 citations

Neuroendocrine Aspects of Thermoregulation

1973 • 142 citations

Effect of diet and cold exposure on norepinephrine turnover in pancreas and liver.

1979 • 136 citations

The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings

1979 • 136 citations

The role of sodium and calcium ions in the hypothalamus in the control of body temperature of the unanaesthetized cat

1971 • 130 citations

Effect of Energy Restriction on Total Heat Production, Basal Metabolic Rate, and Specific Dynamic Action of Food in Rats

1981 • 126 citations

Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria

1979 • 124 citations

The effect of propranalol on the calorigenic response in brown adipose tissue of new‐born rabbits to catecholamines, glucagon, corticotrophin and cold exposure

1966 • 121 citations

Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice

1982 • 120 citations

Hypothalamic regulation of energy balance and feeding behavior.

1974 • 115 citations

Throxine and noradrenaline on noradrenaline sensitivity, cold resistance, and brown fat

1970 • 114 citations

Body Temperature: Possible Ionic Mechanism in the Hypothalamus Controlling the Set Point

1970 • 111 citations

Mitochondrien aus braunem Fettgewebe: Entkopplung der Atmungskettenphosphorylierung durch langkettige Fettsäuren und Rekopplung durch Guanosintriphosphat

1969 • 109 citations

The ingestion of food and the recovery of body weight following fasting in the naive rat

1976 • 108 citations

Calorigenic response in obese and nonobese women

1976 • 104 citations

Organ Weights in Three Forms of Experimental Obesity in the Mouse

1957 • 103 citations

The Hypothermia of Hypoglycemia

1972 • 103 citations

Metabolic Origins of Thermogenesis induced by Diet

1968 • 103 citations

Nonphosphorylating Respiration of Mitochondria from Brown Adipose Tissue of Rats

1966 • 103 citations

HORMONAL FACTORS INFLUENCING FAT DEPOSITION IN THE INTERSCAPULAR BROWN ADIPOSE TISSUE OF THE WHITE RAT¹

1953 • 103 citations

Gonadal hormones and body temperature in rats: Effects of estrous cycles, castration and steroid replacement

1976 • 102 citations

GDP binding to rat brown fat mitochondria: effects of thyroxine at different ambient temperatures

1981 • 101 citations

Accuracy of Basal Body Temperature for Ovulation Detection

1976 • 99 citations

Stimulation of Metabolism of Rat Brown Adipose Tissue by Addition of Lipolytic Hormones in Vitro

1966 • 99 citations

SECTION OF BIOLOGICAL AND MEDICAL SCIENCES: HYPOTHALAMIC OBESITY IN RATS WITHOUT HYPERPHAGIA*

1967 • 98 citations

Energy balance in ovariectomized rats with and without estrogen replacement

1980 • 98 citations

Gold thioglucose damage to the satiety center: inhibition in diabetes

1968 • 95 citations

Thermogenic Responses of Brown Adipocytes to Noradrenaline and Glucagon in Heat-acclimated and Cold-acclimated Rats

1979 • 95 citations

Effects of feeding a palatable ‘cafeteria’ diet on energy balance in young and adult lean (+/?) Zucker rats

1982 • 93 citations

Factors influencing deposition of glycogen in adipose tissue of the rat

1946 • 93 citations

Development of obesity in diabetic mice pair-fed with lean siblings.

1977 • 92 citations

Functional disconnection of brown adipose tissue in hypothalamic obesity in rats

1981 • 92 citations

Brown adipose tissue in the new‐born calf (Bos taurus).

1975 • 91 citations

An Assessment of Human Regulatory Nonshivering Thermogenesis

1980 • 91 citations

PLASMA THYROXINE, 3,3′,5-TRIIODOTHYRONINE AND 3,3′,5′-TRIIODOTHYRONINE DURING 3-ADRENERGIC BLOCKADE IN. HYPERTHYROIDISM

1977 • 89 citations

INFLUENCE OF PERIODICITY OF EATING ON ADIPOSE TISSUE METABOLISM IN THE RAT

1965 • 86 citations

Oxygen consumption and locomotor activity during restricted feeding and realimentation

1981 • 84 citations

Effectors of Thermogenesis

1978 • 83 citations

A STUDY OF WEIGHT REGULATION IN THE ADULT HUMAN BODY DURING OVER-NUTRITION

1922 • 83 citations

GDP-binding to the brown fat mitochondria of developing and cold-adapted rats

1980 • 83 citations

Effect of Carbohydrate and Noncarbohydrate Sources of Calories on Plasma 3,5,3′-Triiodothyronine Concentrations in Man*

1979 • 82 citations

Associative Dynamic Effects of Protein, Carbohydrate and Fat

1944 • 82 citations

The Occurrence of Brown Adipose Tissue in Perirenal Fat in Japanese

1975 • 80 citations

The influence of malnutrition on the postprandial metabolic rate and respiratory quotient

1972 • 80 citations

The central control of shivering and non‐shivering thermogenesis in the rat.

1978 • 80 citations

The sympathetic nervous system as a homeostatic mechanism. I. Absolute need for sympathetic nervous function in body temperature maintenance of cold-exposed rats.

1967 • 79 citations

A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man

1982 • 77 citations

Effects of Manipulating Dietary Protein and Energy Intake on Energy Balance and Thermogenesis in the Pig

1980 • 77 citations

Insulin and glucagon as determinants of body weight set point and microregulation in rats.

1978 • 73 citations

THE PITUITARY-ADRENAL SYSTEM OF THE GENETICALLY OBESE (ob/ob) MOUSE

1975 • 69 citations

Two sympathetic nerve supplies to brown adipose tissue of the rat

1969 • 68 citations

Acute effects of food, 2-deoxy-d-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats

1981 • 67 citations

Effects of adrenalectomy on the obese-hyperglycemic syndrome in mice (gene symbolob)

1973 • 66 citations

Sympathetic Activation of Thyroid Hormone Secretion in Mice

1972 • 64 citations

Thermoregulation in exercising man during dehydration and hyperhydration with water and saline

1971 • 63 citations

Ouabain-sensitive component of brown fat thermogenesis

1973 • 62 citations

Rapid rise in plasma glucagon induced by acute cold exposure in man and rat

1981 • 62 citations

Site of action of gold thioglucose in the hypothalamic satiety center

1970 • 61 citations

Feeding pattern and nutritional adaptations

1969 • 60 citations

A paradox in the control of energy intake in the rat

1978 • 60 citations

A 5-year study of the daily food consumption of South African university students

1965 • 59 citations

Thyroid and Growth Responses of Young Zucker Obese and Lean Rats to a Low Protein-High Carbohydrate Diet

1980 • 58 citations

High Number of High-Affinity Binding Sites for (-)-[3H]Dihydroalprenolol on Isolated Hamster Brown-Fat Cells. A Study of the beta-Adrenergic Receptors

1979 • 58 citations

Brown adipose tissue of cafeteria-fed rats

1981 • 58 citations

A Comparative Survey of Brown Fat in the Neck and Axilla of Mammals at Birth

1971 • 57 citations

EFFECTS OF DIET AND ACUTE NORADRENALINE TREATMENT ON BROWN ADIPOSE TISSUE DEVELOPMENT AND MITOCHONDRIAL PURINE‐NUCLEOTIDE BINDING

1982 • 57 citations

Maximal Thermogenic Capacity and Body Temperatures of White-Footed Mice (Peromyscus) in Summer and Winter

1980 • 56 citations

Role of glucagon in metabolic acclimation to cold and heat

1978 • 53 citations

Changes in interscapular brown adipose tissue of the rat during perinatal and early postnatal development and after cold acclimation—I. Activities of some respiratory enzymes in the tissue

1970 • 51 citations

Response of body weight to a low carbohydrate, high fat diet in normal and obese subjects

1973 • 48 citations

Adrenergic receptors mediating depolarization in brown adipose tissue

1976 • 48 citations

Evidence for the presence of brown adipose tissue in the pig

1981 • 47 citations

Thyroid and adrenal response to acute cold exposure in man.

1970 • 47 citations

The Heat Increments of Diets Balanced and Unbalanced with Respect to Protein

1939 • 47 citations

Increase of glucagon receptors in hyperthyroidism

1976 • 46 citations

Role of gonadal hormones in diet selection and food utilization in female rats

1980 • 46 citations

The function of glucocorticoids in thermogenesis.

1979 • 46 citations

Factors influencing the acute effect of food on oxygen consumption in the rat.

1982 • 45 citations

Growth and the development of dietary obesity in adulthood of rats which have been undernourished during development

1980 • 42 citations

Functional and anatomical characteristics of the nerve-brown adipose interaction in the rat

1976 • 41 citations

Hypothermia following injection of 2-deoxy-D-glucose into selected hypothalamic sites

1980 • 41 citations

The sympathetic nervous system as a homeostatic mechanism. II. Effect of adrenocortical hormones on body temperature maintenance of cold-exposed adrenalectomized rats.

1967 • 40 citations

Effects of Adrenalectomy on Thyroid Function and Insulin Levels in Obese (ob/ob) Mice

1978 • 37 citations

Intrathyroidal Amines and the Synthesis of Thyroid Hormone

1973 • 36 citations

Comparative Measurements of in Vitro Thermogenesis of Brown Adipose Tissue from Control and Cold Adapted Rats

1978 • 35 citations

Na+, K+-ATPase activity and noradrenaline turnover in brown adipose tissue of rats exhibiting diet-induced thermogenesis

1981 • 35 citations

Alpha1-adrenergic activation of phosphatidylinositol labeling in isolated brown fat cells

1980 • 34 citations

INCREASE IN THE BLOOD FLOW THROUGH BROWN ADIPOSE TISSUE IN RESPONSE TO COLD EXPOSURE AND NOREPINEPHRINE IN THE RAT

1967 • 33 citations

Evidence that Brown Adipose Tissue Is a Glucocorticoid Target Organ*

1978 • 33 citations

Cellular events underlying catecholamine-induced thermogenesis: cation transport in brown adipocytes.

1979 • 32 citations

Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin

1973 • 32 citations

Stimulation of Glucose Metabolism in Brown Adipose Tissue by Addition of Insulin in Vitro

1966 • 32 citations

Coupling of signals to brown fat: α and β adrenergic responses in intact rats

1977 • 31 citations

THE RATES OF PLASMA CORTISOL ENTRY AND CLEARANCE IN SHEEP BEFORE AND DURING THEIR EXPOSURE TO A COLD, WET ENVIRONMENT

1970 • 31 citations

Propranolol and pyrogen effects of shivering and nonshivering thermogenesis in rats

1976 • 31 citations

Catecholamine and Thyroid Hormone Influence on Brown Fat Na⁺, K⁺-ATPase Activity and Thermogenesis in the Rat

1982 • 30 citations

Catecholamine-thyroid hormone interaction in cold-acclimated rats.

1979 • 30 citations

Effects of Cations on Brown Adipose Tissue in Relation to Possible Metabolic Consequences of Membrane Depolarisation

1981 • 29 citations

THE EFFECT OF LIPOLYTIC HORMONES AND THEOPHYLLINE ON HEAT PRODUCTION IN BROWN ADIPOSE TISSUE IN VIVO

1967 • 29 citations

The Effects of Thyroxine and Isopropylnoradrenaline on Cytochrome Oxidase Activity in Brown Adipose Tissue

1973 • 29 citations

Microcalorimetry of isolated mitochondria from brown adipose tissue

1979 • 29 citations

Thermic Effects of Ethanol in the Rat and Man

1974 • 29 citations

A comparison between the effects of cold exposure in vivo and of noradrenaline in vitro on the metabolism of the brown fat of new-born rabbits

1970 • 28 citations

Effect of altitude on dietary-induced thermogenesis at rest and during light exercise in man

1978 • 27 citations

The effects of central body and trunk skin temperatures on reflex vasodilatation in the hand

1964 • 27 citations

SYMPATHETIC MECHANISMS IN DIET‐INDUCED THERMOGENESIS: MODIFICATION BY CICLAZINDOL AND ANORECTIC DRUGS

1981 • 27 citations

Independence of food intake and obesity following ventromedial hypothalamic lesions in the rat

1974 • 27 citations

Lasting Effect of Infantile Cold Experience on Cold Tolerance in Adult Rats

1979 • 26 citations

Non-genetic models of obesity

1979 • 26 citations

Improved cold tolerance in glucagon-treated rats

1981 • 24 citations

An improved method for flow dialysis studies with highly increased diffusion rates

1976 • 24 citations

Effects of acute starvation on cold-induced thermogenesis in the preweanling rat

1974 • 24 citations

The part played by ACTH in determining the rate of aldosterone secretion during operative stress

1964 • 23 citations

Effect of neonatal decerebration on thermogenesis during starvation and cold exposure in the rat

1975 • 23 citations

Observations on the mechanism of salicylate‐induced antipyresis

1970 • 22 citations

Androgens, estrogens and their anti-hormones: Effects on body weight and food consumption

1979 • 22 citations

Thermoregulatory and related responses to 2-deoxy-D-glucose administration in humans

1980 • 22 citations

POSSIBLE STIMULATION OF THERMOGENESIS IN BROWN ADIPOSE TISSUE BY THYROID-STIMULATING HORMONE

1975 • 21 citations

Cold-induced thermogenesis in dogs: its reduction by moderate hypoxia.

1973 • 21 citations

OXYGEN CONSUMPTION OF BROWN ADIPOSE TISSUE IN NORMAL AND HYPOTHYROID MICE

1967 • 20 citations

Calorigenic effects of noradrenaline and glucagon on white adipocytes in cold- and heat-acclimated rats

1979 • 20 citations

The Ethiopia applied nutrition project

1976 • 18 citations

ESSAYS ON TEMPERATURE REGULATION

1972 • 17 citations

The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes

1981 • 16 citations

Thermogenesis induced by cafeteria feeding in young growing rats.

1980 • 16 citations

Metabolic Effects of Glucagon in the Young Pig

1980 • 16 citations

Intra-strain differences in the response to overfeeding in the rat.

1980 • 16 citations

Evidence of diurnal fluctuation of sensitivity to noradrenaline in the rat — the role of the thyroid

1976 • 16 citations

Development of hyperphagia in female rats with ventromedial hypothalamic lesions placed at four different ages

1966 • 15 citations

Characterization of [3H]Dihydroergocryptine Binding Sites in Brown Adipose Tissue. Evidence for the Presence of alpha-Adrenergic Receptors.

1980 • 14 citations

Sympathetic inhibition of thermogenesis in the infant rat: possible glucostatic control

1977 • 13 citations

Circadian and circannual variations in growth and cold resistance of warm acclimated rats and their relationship with the geomagnetic activity

1979 • 11 citations

Hypothermia in hypoglycaemia.

1984 • 11 citations

INFLUENCE OF PROSTAGLANDIN E₁ ON LIPOLYSIS INDUCED BY NORADRENALINE, ISOPROPYLNORADRENALINE, THEOPHYLLINE, AND DIBUTYRYL cAMP IN HUMAN OMENTAL ADIPOSE TISSUE IN VITRO

1970 • 11 citations

Sex differences in response to dietary carbohydrates

1976 • 10 citations

Calorigenic effect of insulin in hypothermic dogs

1979 • 10 citations

The effect of noradrenaline on heat production in the new-born pig

1973 • 9 citations

Effects of adrenalectomy and thyroidectomy on in vivo action of glucagon in brown adipose tissue.

1977 • 7 citations

Glucose Tolerance in Mildly and Moderately Diabetic Rats Exposed to Cold

1963 • 6 citations

Effects of tube-feeding iso-energetic amounts of various dietary lipids on energy balance in the rat.

1979 • 6 citations

Fructose-1,6-diphosphatase activity in brown adipose tissue of the developing rat

1977 • 5 citations

GLUCAGON AND TEMPERATURE ACCLIMATION

1981 • 5 citations

6-OH-Dopamine and the Development of Brown Adipose Tissue in the Cold

1978 • 5 citations

T₄-T₃Shift during the Postprandial Period After Glucose Load in Obese Children before and after Hypocaloric Diet - One Factor for Postprandial Thermogenesis?

1981 • 5 citations

The nervous system and lipid metabolism of adipose tissue. 2. Influence of denervation on the lipogenetic activity of adrenocortical hormones.

1961 • 4 citations

Metabolic responses to food atropine and 2 deoxy d glucose in zucker rats

1982 • 4 citations

Corticotropin and nonshivering thermogenesis

1977 • 4 citations

Mechanism of systemic hemodynamic response during limb reactive hyperemia

1969 • 4 citations

THE INFLUENCE OF THYROXINE ON BROWN FAT THERMOGENESIS

1981 • 4 citations

Lipolytic and lipogenic activities of adipose tissue during spontaneous fat depletion and repletion [proceedings].

1976 • 3 citations

Energy expenditure of rats tube-fed at different energy levels [proceedings].

1979 • 3 citations

The effect of age on the thermic energy of 'catch-up' growth.

1973 • 2 citations

The effect of depletion-repletion on calorie utilization.

1969 • 2 citations

Evidence that body size does not determine voluntary food intake in the rat

1980 • 2 citations

Gold thioglucose treatment selectively disrupts dietary regulation of sympathetic activity in the mouse

1979 • 2 citations

A futile energy cycle in adult rats given a low-protein diet at high levels of energy intake [proceedings]?

1976 • 1 citations

PEROXISOMES IN BROWN FAT

1981 • 1 citations