Cyclosporine, Low-Density Lipoprotein, and Cholesterol

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Astrocytes induce blood–brain barrier properties in endothelial cells

1987 • 1,593 citations

CYCLOSPORIN A IN PATIENTS RECEIVING RENAL ALLOGRAFTS FROM CADAVER DONORS

1978 • 1,010 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras

1981 • 681 citations

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1987 • 666 citations

Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2

1981 • 632 citations

GYNAECOLOGISTS' ATTITUDES TO ABORTION

1989 • 605 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Central Nervous System Toxicity after Liver Transplantation

1987 • 500 citations

Liver Transplantation with Use of Cyclosporin a and Prednisone

1981 • 485 citations

Defective Lipoprotein Receptors and Atherosclerosis

1983 • 469 citations

Long-Term Treatment of Cerebrotendinous Xanthomatosis with Chenodeoxycholic Acid

1984 • 361 citations

HEART-LIVER TRANSPLANTATION IN A PATIENT WITH FAMILIAL HYPERCHOLESTEROLAEMIA

1984 • 359 citations

Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.

1980 • 351 citations

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

1982 • 271 citations

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells.

1986 • 253 citations

NEUROLOGICAL COMPLICATIONS FOLLOWING LIVER TRANSPLANTATION

1987 • 249 citations

Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring.

1987 • 233 citations

Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid.

1980 • 221 citations

CYCLOSPORIN A FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE IN MAN

1978 • 215 citations

Cyclophilin: distribution and variant properties in normal and neoplastic tissues.

1986 • 214 citations

Porphyrin-lipoprotein association as a factor in porphyrin localization

1986 • 200 citations

Regulatory Serum Lipoproteins: Regulation of Lymphocyte Stimulation by a Species of Low Density Lipoprotein

1976 • 187 citations

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*

1979 • 173 citations

Metabolism of cyclosporine.

1985 • 172 citations

PSYCHIATRIC INDICATIONS FOR THE TERMINATION OF PREGNANCY

1971 • 164 citations

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

1987 • 150 citations

Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In.

1986 • 148 citations

Cerebral blindness and encephalopathy with cyclosporin A toxicity

1987 • 148 citations

Advances in hepatic encephalopathy and urea cycle diseases

1985 • 146 citations

The Astrocyte in Liver Disease

1981 • 140 citations

Inhibition of T‐Cell Activity by Cyclosporin A

1982 • 133 citations

Effect of cyclosporin A on T cell function in vitro: the mechanism of suppression of T cell proliferation depends on the nature of the T cell stimulus as well as the differentiation state of the responding T cell.

1982 • 123 citations

Overexpression of Low Density Lipoprotein (LDL) Receptor Eliminates LDL from Plasma in Transgenic Mice

1988 • 121 citations

BREAST PROSTHESES

1975 • 111 citations

Binding of cyclosporine by human lymphocytes and phospholipid vesicles.

1983 • 107 citations

Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells.

1982 • 107 citations

Antischistosomal effects of cyclosporin A

1981 • 103 citations

Effect of Cyclosporin A on prostacyclin synthesis by vascular tissue

1983 • 102 citations

Long-term effects of cyclosporin A on cultured mouse pancreatic islets

1984 • 102 citations

Restrictive Transport of a Lipid‐Soluble Peptide (Cyclosporin) Through the Blood–Brain Barrier

1985 • 100 citations

Selective delivery of cytotoxic compounds to cells by the LDL pathway

1984 • 97 citations

Increased Concentrations of Cholestanol and Apolipoprotein B in the Cerebrospinal Fluid of Patients with Cerebrotendinous Xanthomatosis

1987 • 96 citations

Tissue distribution, disposition, and metabolism of cyclosporine in rats.

1987 • 90 citations

Cyclosporin receptors on human lymphocytes.

1982 • 89 citations

Experimental Studies of Blood Brain Barrier Permeability in Acute Hepatic Failure

1984 • 89 citations

Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.

1987 • 89 citations

Interaction of cyclosporin A with human lipoproteins

1986 • 85 citations

Targeted killing of cultured cells by receptor-dependent photosensitization.

1981 • 77 citations

Effect of Cyclosporine a on Male Reproduction in Rats

1987 • 74 citations

Advances in Hepatic Encephalopathy and Urea Cycle Diseases

1984 • 73 citations

Effect of FK-506 on human mixed lymphocyte reaction in vitro.

1987 • 72 citations

Liver transplantation for treatment of cardiovascular disease: Comparison with medication and plasma exchange in homozygous familial hypercholesterolemia

1987 • 70 citations

CYCLOSPORIN-A DEPOSITS IN RENAL ALLOGRAFTS

1983 • 69 citations

Cyclosporin: measurement of fraction unbound in plasma

1987 • 68 citations

Identification of a lymphocyte surface receptor for low density lipoprotein inhibitor, an immunoregulatory species of normal human serum low density lipoprotein.

1978 • 67 citations

Ciclosporin in Autoimmune Diseases

1985 • 63 citations

Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes.

1987 • 61 citations

mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.

1987 • 60 citations

Inhibition of T lymphocyte activation by cyclosporin A: interference with the early activation of plasma membrane phospholipid metabolism.

1986 • 56 citations

Cyclosporine inhibits prostacyclin production by cultured human endothelial cells.

1987 • 54 citations

The transport of cyclosporine in association with plasma lipoproteins in heart and liver transplant patients.

1985 • 53 citations

Psychiatric disorders in patients with cerebrotendinous xanthomatosis

1988 • 48 citations

Cyclosporin A inhibits rDNA transcription in lymphosarcoma P1798 cells.

1987 • 37 citations

HLA‐DR Antigens Render Interleukin‐2‐Producer T Lymphocytes Sensitive to Interleukin‐1

1981 • 37 citations

BIOCHEMICAL MECHANISMS UNDERLYING CYCLOSPORINE-INDUCED NEPHROTOXICITY EFFECT OF CONCOMITANT ADMINISTRATION OF PREDNISOLONE

1987 • 37 citations

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells

1987 • 37 citations

Mitogen-stimulated calcium ion accumulation by lymphocytes. Influence of plasma lipoproteins.

1979 • 35 citations

Computed tomography in cerebrotendinous xanthomatosis

1981 • 35 citations

Effect of cyclosporin on blood pressure and renin-aldosterone axis in rats

1987 • 34 citations

Magnetic resonance imaging in cerebrotendinous xanthomatosis

1986 • 32 citations

EFFECTS OF CYCLOSPORINE A (CSA) ON LDL-RECEPTOR ACTIVITY AND BILE-ACID SYNTHESIS IN HEPATOCYTE MONOLAYER-CULTURES AND INVIVO IN RAT

1987 • 29 citations

Direct augmentation by cyclosporin A of the vascular contractile response to nerve stimulation.

1987 • 29 citations

Combined transplantation of heart and liver from two different donors in a patient with familial type IIa hypercholesterolemia.

1986 • 28 citations

Cerebrotendinous xanthomatosis: A review of biochemical findings of the patient population in the netherlands

1987 • 27 citations

A new method for measuring the free fraction of cyclosporin in plasma by equilibrium dialysis

1987 • 25 citations

Adverse effects of cyclosporine therapy following liver transplantation.

1987 • 24 citations

Distribution of cyclosporine in blood of a renal-transplant recipient with type V hyperlipoproteinemia.

1987 • 23 citations

Effect of cyclosporin A on the morphology and function of the ovary and fertility in the rabbit.

1984 • 22 citations

EEG in Cerebrotendinous Xanthomatosis (CTX)

1982 • 22 citations

Cyclosporin A-induced hyperreninemic hypoaldosteronism. A model of adrenal resistance to angiotensin II.

1987 • 19 citations

Uptake and metabolism of lactosylceramide on low density lipoproteins in cultured proximal tubular cells from normal and familial hypercholesterolemic homozygotes.

1986 • 19 citations

FK-506 enhances cyclosporine uptake by peripheral blood lymphocytes.

1987 • 18 citations

Efficacy of incorporating cyclosporine into liposomes to reduce its nephrotoxicity.

1988 • 17 citations

The free fraction of cyclosporine in plasma: clinical findings with a new method.

1988 • 17 citations

Cyclosporine A-induced side effects related to a low total serum cholesterol level: an indication for a free cyclosporine A assay?

1988 • 15 citations

Metabolic basis of inherited disease, fifth edition

1983 • 15 citations

Preparation and efficacy of cyclosporin-A liposomes for prolongation of cardiac allograft survival.

1981 • 12 citations

The Influence of Human Plasma Lipoproteins and Fatty Acids in Immunological Reactions

1984 • 11 citations

Significance of Middle Molecules in the Pathogenesis of Hepatic Encephalopathy

2015 • 11 citations

Suppressor macromolecules.

1984 • 10 citations

The Immunosuppressive Activities of Different Cyclosporins are Correlated to Inhibition of the Early Membrane Phospholipid Metabolism in Activated Lymphocytes

1987 • 8 citations

Deleted Work

1955 • 0 citations