The cell-specific elastase I enhancer comprises two domains.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Transcriptional control in the production of liver-specific mRNAs

1981 • 593 citations

High efficiency gene transfer into mammalian cells

1984 • 498 citations

The SV40 enhancer is composed of multiple functional elements that can compensate for one another

1986 • 293 citations

Specific expression of an elastase–human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

1985 • 243 citations

Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice

1984 • 239 citations

The saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties

1987 • 214 citations

Contactpoint analysis of the HeLa nuclear factor I recognition site reveals symmetrical binding at one side of the DNA helix.

1987 • 168 citations

Cell-specific enhancers in the rat exocrine pancreas.

1986 • 150 citations

Hormonal stimulation in the exocrine pancreas results in coordinate and anticoordinate regulation of protein synthesis.

1984 • 132 citations

The N-terminal arms of λ repressor wrap around the operator DNA

1982 • 118 citations

Molecular Model of the Interaction Between the Glucocorticoid Receptor and the Regulatory Elements of Inducible Genes

1986 • 117 citations

Structure of the two related elastase genes expressed in the rat pancreas.

1984 • 116 citations

Elastase I Promoter Directs Expression of Human Growth Hormone and SV40 T Antigen Genes to Pancreatic Acinar Cells in Transgenic Mice

1985 • 110 citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

1987 • 109 citations

Rapid electroelution of nucleic acids from agarose and acrylamide gels

1982 • 105 citations

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

1987 • 78 citations

Interaction of the cAMP receptor protein with the lac promoter.

1980 • 78 citations

Two distinct adaptive responses in the synthesis of exocrine pancreatic enzymes to inverse changes in protein and carbohydrate in the diet

1984 • 66 citations

Rapid assay for detection ofEschenchia colixanthine-guanine phosphoribosyltransferase activity in transduced cells

1985 • 34 citations

Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes

1986 • 12 citations

Expression of the pancreatic elastase I gene in transgenic mice

1987 • 10 citations