Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium

1952 • 1,001 citations

Regimen-related toxicity in patients undergoing bone marrow transplantation.

1988 • 876 citations

Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

1992 • 755 citations

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

1996 • 747 citations

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

1989 • 741 citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

1994 • 562 citations

Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

1996 • 542 citations

Secondary Cancers after Bone Marrow Transplantation for Leukemia or Aplastic Anemia

1989 • 425 citations

Adeno-associated virus general transduction vectors: analysis of proviral structures

1988 • 347 citations

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1993 • 345 citations

Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.

1992 • 313 citations

A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection

1991 • 308 citations

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

1994 • 306 citations

In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction in Factor IX-Deficient Dogs

1993 • 305 citations

Adeno-associated virus vectors preferentially transduce cells in S phase.

1994 • 272 citations

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

1981 • 250 citations

Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors

1994 • 228 citations

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors

1994 • 227 citations

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

1995 • 220 citations

DNA amplification of adeno-associated virus as a response to cellular genotoxic stress.

1988 • 213 citations

Hepatic Gene Therapy: Persistent Expression of Human α1-Antitrypsin in Mice after Direct Gene Delivery In Vivo

1992 • 178 citations

Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B

1989 • 177 citations

EPIDEMIOLOGY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN A NURSERY POPULATION1

1968 • 172 citations

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells

1995 • 139 citations

Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5′ flanking region by deletion/substitution.

1988 • 133 citations

A SEROEPIDEMIOLOGIC STUDY OF ADENOVIRUS-ASSOCIATED VIRUS INFECTION IN INFANTS AND CHILDREN

1971 • 130 citations

Effects of Gamma Irradiation on the Transduction of Dividing and Nondividing Cells in Brain and Muscle of Rats by Adeno-Associated Virus Vectors

1996 • 128 citations

Liver-directed gene therapy: quantitative evaluationof promoter elements by using in vivo retroviral transduction.

1994 • 111 citations

Integration of adeno-associated virus vectors in CD34+ human hematopoietic progenitor cells after transduction

1996 • 105 citations

Persistent Gene Expression After Retroviral Gene Transfer into Liver CellsIn Vivo

1991 • 99 citations

Seroepidemiological and Ecological Studies of the Adenovirus-Associated Satellite Viruses

1970 • 86 citations

Hepatitis B surface antigen produced by a human hepatoma cell line

1979 • 81 citations

Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes

1990 • 66 citations

Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes

1994 • 65 citations

Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes

1994 • 62 citations

Prolonged Expression of Therapeutic Levels of Human Granulocyte Colony-Stimulating Factor in Rats Following Gene Transfer to Skeletal Muscle

1996 • 19 citations

Status of Gene Transfer for Hemophilia A and B

1991 • 15 citations