The Role of Nitrates in Coronary Heart Disease

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction

1992 • 1,132 citations

GISSI-3: effects of lisiriopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction

1994 • 1,117 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Transient asymptomatic ST segment depression during daily activity

1975 • 516 citations

Mechanism of tolerance development to organic nitrates.

1973 • 486 citations

The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response.

1981 • 467 citations

Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications. Effect of timing, dosage, and infarct location.

1988 • 396 citations

EFFECT OF INTRAVENOUS NITRATES ON MORTALITY IN ACUTE MYOCARDIAL INFARCTION: AN OVERVIEW OF THE RANDOMISED TRIALS

1988 • 392 citations

Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin.

1986 • 371 citations

Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

1987 • 366 citations

Sulfhydryl requirement for relaxation of vascular smooth muscle.

1973 • 254 citations

Effect of Intervals between Doses on the Development of Tolerance to Isosorbide Dinitrate

1987 • 218 citations

NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.

1879 • 215 citations

Tolerance to intravenous nitroglycerin in patients with congestive heart failure: Role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine

1990 • 211 citations

Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina

1989 • 190 citations

Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin.

1981 • 178 citations

Desensitization to nitroglycerin in vascular smooth muscle from rat and human

1986 • 153 citations

Myocardial Ischemia Caused by Distal Coronary-Artery Constriction in Stable Angina Pectoris

1990 • 152 citations

Hemodynamic effects of nitroglycerin and long-acting nitrates

1985 • 151 citations

A randomized prospective trial of intravenous nitroglycerin in patients with acute myocardial infarction.

1983 • 137 citations

Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy

1983 • 134 citations

Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate

1979 • 130 citations

Efficacy and safety of extended-release isosorbide mononitrate for stable effort angina pectoris

1993 • 113 citations

Antiplatelet and antithrombotic effects of organic nitrates

1992 • 111 citations

Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P-450

1989 • 109 citations

Biochemical mechanism of organic nitrate action

1992 • 108 citations

Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist.

1989 • 94 citations

Endothelium-derived nitric oxide: the endogenous nitrovasodilator in the human cardiovascular system

1991 • 91 citations

Medical treatment of patients with severe exertional and rest angina: double blind comparison of beta blocker, calcium antagonist, and nitrate.

1987 • 91 citations

Reduction of infarct size in patients with inferior infarction with intravenous glyceryl trinitrate. A randomised study.

1983 • 79 citations

Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease

1990 • 72 citations

Transdermal nitroglycerin in angina pectoris: Efficacy of intermittent application

1987 • 67 citations

Nitrates in different vascular beds, nitrate tolerance, and interactions with endothelial function

1992 • 61 citations

Lack of Pharmacologic Tolerance and Rebound Angina Pectoris during Twice-Daily Therapy with Isosorbide-5-Mononitrate

1994 • 59 citations

Intravenous Nitroglycerin for Rest Angina

1982 • 55 citations

Induction and circumvention of nitrate tolerance applying different dosage intervals

1987 • 52 citations

Interactions between nitroglycerin and endothelium in vascular smooth muscle relaxation

1991 • 51 citations

Effects of diuretic therapy on the development of tolerance during continuous therapy with nitroglycerin

1992 • 45 citations

Role of nitrates in angina pectoris

1992 • 45 citations

Propylene glycol-induced heparin resistance during nitroglycerin infusion

1985 • 38 citations

Interactions between organic nitrates and thiol groups

1991 • 36 citations

Neurohormonal activation during nitrate therapy: A possible mechanism for tolerance

1992 • 35 citations

Endothelium- and sydnonimine-induced responses of native and cultured aortic smooth muscle cells are not impaired by nitroglycerin tolerance

1989 • 35 citations

Tolerance to glyceryl trinitrate patches: prevention by intermittent dosing.

1987 • 33 citations

Nitrates and calcium antagonists for silent myocardial ischemia

1988 • 31 citations

Nitroglycerin causes vasodilatation within ischaemic myocardium

1980 • 29 citations

Use of nitrates in unstable angina pectoris

1987 • 27 citations

Role of nitrates in unstable angina pectoris

1992 • 26 citations

Quantitative coronary angiography: evidence of a sustained increase in vascular smooth muscle tone in coronary artery stenoses.

1983 • 25 citations

Circulatory counter-regulations induced by continuous administration of nitroglycerin.

1989 • 21 citations

Normal and pathophysiologic considerations of endothelial regulation of vascular tone and their relevance to nitrate therapy

1992 • 20 citations

Efficacy of isosorbide-5-mononitrate on painful and silent myocardial ischemia after myocardial infarction

1990 • 17 citations

Treatment of Silent Myocardial Ischemia with Transdermal Nitroglycerin Added to Beta-Blockers and Alprazolam

1986 • 14 citations

Effects of prolonged nitroglycerin infusion in patients with acute myocardial infarction

1978 • 13 citations

Efficacy of transdermal nitroglycerin in combination with an ACE-inhibitor in patients with chronic stable angina pectoris

1991 • 13 citations

Persistent improvement in left ventricular geometry and function by prolonged nitroglycerin therapy after anterior transmural acute myocardial infarction

1990 • 9 citations

Coronary stenosis dilation by low dose intravenous nitroglycerin

1989 • 9 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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