Regulation of Gastric Acid Secretion

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides

1980 • 645 citations

Somatostatin Cell Processes as Pathways for Paracrine Secretion

1979 • 499 citations

The gastric secretion of drugs: a pH partition hypothesis.

1957 • 466 citations

Gastric Acid Secretion Rate and Buffer Content of the Stomach after Eating. RESULTS IN NORMAL SUBJECTS AND IN PATIENTS WITH DUODENAL ULCER

1973 • 451 citations

Effects of Prostaglandins on Adenosine 3′,5′-Monophosphate Levels in Fat and Other Tissues

1968 • 357 citations

pH dependence of acid secretion and gastrin release in normal and ulcer subjects.

1975 • 330 citations

EXPERIENCE WITH 45 RENAL HOMOTRANSPLANTATIONS IN MAN.

1965 • 309 citations

Inhibition of gastric secretion by prostaglandins

1967 • 285 citations

STUDIES ON DISPERSED PANCREATIC EXOCRINE CELLS

1974 • 263 citations

On the chemical mechanism of gastric secretion

1905 • 245 citations

Secretagogue stimulation of [14C]aminopyrine accumulation by isolated canine parietal cells

1980 • 182 citations

Influence of Feeding and Sham Feeding upon Serum Gastrin and Gastric Acid Secretion in Control Subjects and Duodenal Ulcer Patients

1974 • 168 citations

Gastric Secretion and Emptying after Ordinary Meals in Duodenal Ulcer

1977 • 166 citations

Inhibition of Histamine-, Pentagastrin-, and Insulin-Stimulated Canine Gastric Secretion by Pure “Gastric Inhibitory Polypeptide”

1972 • 163 citations

Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.

1976 • 153 citations

Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated [14C]aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells.

1980 • 146 citations

Plasma Gastrin and Gastric Acid Responses to Sham Feeding and Feeding in Dogs

1972 • 142 citations

Studies on the role of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects.

1977 • 137 citations

Amine mechanisms in enterochromaffin and enterochromaffin-like cells of gastric mucosa in various mammals

1970 • 134 citations

Effect of Atropine on Vagal Release of Gastrin and Pancreatic Polypeptide

1979 • 133 citations

Localization of cells containing and forming histamine in the gastric mucosa of the rat

1967 • 128 citations

Thyrotropin-Releasing Hormone: Stimulation of Colonic Activity Following Intracerebroventricular Administration

1977 • 115 citations

The Effect of Atropine on Plasma Gastrin Response to Feeding

1971 • 113 citations

Electron microscopic identification of the histamine-storing argyrophil (enterochromaffin-like) cells in the rat stomach

1971 • 106 citations

Stimulation of Gastric Secretion and Gastrin Release by Single Oral Doses of Calcium Carbonate in Man

1973 • 106 citations

Proof of a pyloro-oxyntic reflex for stimulation of acid secretion.

1974 • 105 citations

Gastrin

1975 • 103 citations

Gastric Adenosine Triphosphatases: A Review of their Possible Role in HCL Secretion

1977 • 99 citations

Light and electron microscopic identification of the histamine-storing argyrophil (ECL) cell in murine stomach and of its equivalent in other mammals

1971 • 97 citations

Biogenesis and physiology of histamine.

1971 • 93 citations

Role of Gastrin Heptadecapeptide in the Acid Secretory Response to Amino Acids in Man

1978 • 93 citations

Effect of Secretin and Cholecystokinin on Pentagastrin-Stimulated Gastric Secretion in Man

1970 • 92 citations

Effect of Antral Denervation on Gastrin Release by Sham Feeding and Insulin Hypoglycemia in Dogs

1972 • 91 citations

Topography of somatostatin cells in the stomach of the rat: Possible functional significance

1979 • 85 citations

The Effect of 16,16-Dimethyl Prostaglandin E2 on Meal-Stimulated Gastric Acid Secretion and Serum Gastrin in Duodenal Ulcer Patients

1976 • 85 citations

Distention-induced gastrin release

1980 • 82 citations

Effects of Atropine and of Antral Acidification on Gastrin Release and Acid Secretion in Response to Insulin and Feeding in Dogs

1972 • 80 citations

The Effect of Acute Hyperglycemia on Meal-Stimulated Gastric, Biliary, and Pancreatic Secretion, and Serum Gastrin

1976 • 75 citations

Effect of antrum exclusion on endocrine cells of rat stomach.

1979 • 73 citations

III. On the nature of the acid and saline matters usually ex­isting in the stomachs of animals

1824 • 70 citations

Gastric Acid Responses to Adequate and Modified Sham Feeding and to Insulin Hypoglycemia in Duodenal Ulcer Patients

1978 • 65 citations

Argentophile and argentaffin cells in the gastric mucosa of the rat

1948 • 65 citations

Electron microscopic radioautographic identification of the ECL cell as the histamine-synthesizing endocrine cell in the rat stomach

1979 • 64 citations

Acid inhibition of sham feeding-stimulated gastrin release and gastric acid secretion: Effect of atropine

1980 • 63 citations

A Liver Tumour as an Incidental Finding: Differential Diagnosis and Treatment

2002 • 62 citations

Atropine Enhances Serum Gastrin Response to Insulin in Man

1975 • 61 citations

Interactions between oxidative metabolism and acid secretion in gastric mucosa

1974 • 59 citations

Intestinal Phase of Gastric Acid Secretion: Augmentation of Maximal Response of Heidenhain Pouch to Gastrin and Histamine

1975 • 59 citations

Secretomotor function of the dorsal motor nucleus of the vagus

1969 • 59 citations

Interaction of prostaglandins and histamine with enzymes of cyclic AMP metabolism from guinea pig gastric mucosa.

1976 • 59 citations

Effect of Selective Proximal Vagotomy on Food-Stimulated Gastric Acid Secretion and Gastrin Release in Patients With Duodenal Ulcer

1979 • 58 citations

The Relation of Plasma Gastrin to the Circadian Rhythm of Gastric Acid Secretion in Man

1973 • 54 citations

Electron Microscope Studies on the Endocrine Cells of the Human Gastric Fundus

1971 • 50 citations

Gastric secretion provoked by functional cytoglucopoenia in the nuclei of the solitary tract in the cat.

1980 • 48 citations

Potentiation of Gastric Acid Response in the Dog

1969 • 42 citations

Evidence for an Enterogastric Reflex for the Inhibition of Acid Secretion

1971 • 41 citations

Effect of electrical stimulation of the dorsal nucleus of the vagus nerve on gastric acid secretion in cats

1979 • 39 citations

Cyclic AMP and gastric secretion: the illusive second messenger.

1976 • 37 citations

Stimulation of Gastrin Release in Dogs by Individual Amino Acids

1978 • 36 citations

Ultrastructure and cytochemistry of the gastric mucosa of a reptile, Tiliqua scincoides

1979 • 33 citations

Gastric Acid Responses to Graded i.v. Infusion of Pentagastrin and Histalog in Peptic Ulcer Patients before and after Antrum-bulb Resection

1976 • 32 citations

Prostaglandin production by intact isolated gastric parietal cells

1980 • 31 citations

Some Minor Heresies About Vagotomy

1974 • 31 citations

Effect of fundic distension on gastric acid secretion in man.

1977 • 30 citations

Low Doses of Atropine Enhance Serum Gastrin Response to Food in Dogs

1977 • 30 citations

Participation of the Jejunum and Ileum in Postprandial Gastric Secretion in Man

1977 • 29 citations

Inhibition by Somatostatin of Gastrin Release and Gastric Acid Responses to Meals and to Pentagastrin in Man

1977 • 29 citations

Effect of Secretin on Gastric Function in Normal Subjects and in Patients with Duodenal Ulcer

1976 • 27 citations

Long-term effects of highly selective vagotomy (HSV) in dogs on acid and pepsin secretion

1977 • 25 citations

Perfusion of the Proximal Small Intestine With Peptone Stimulates Gastric Acid Secretion in Man

1977 • 24 citations

Gastric Acid Response to Antrum Distension in Man

1975 • 23 citations

Relation Between Hydrogen Ion Secretion and Oxygen Consumption by Ex Vivo Isolated Canine Stomach, Perfused with Homologous Blood

1972 • 22 citations

Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer.

1969 • 21 citations

Metabolic Changes Associated with Gastric Stimulation

1977 • 20 citations

Effect of atropine and proximal gastric vagotomy on the acid response to fundic distension in man.

1977 • 20 citations

Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.

1978 • 16 citations

Role of Duodenum in Inhibition of Gastric Acid Secretion

1971 • 15 citations

The evaluation of gastric inhibitory polypeptide (GIP) as the enterogastrone

1979 • 13 citations

Lack of potentiation or synergism between histamine and pentagastrin in the fistula dog

1973 • 13 citations

The Origin and Occurrence of Lactic Acid in Human Gastric Contents with Special Reference to Malignant and Non-Malignant Conditions

1930 • 11 citations

Effects of Fundic Distention on Pentagastrin-Stimulated Gastric Acid Secretion in Man

1977 • 11 citations

Metiamide: More than an H2-receptor antagonist

1978 • 8 citations

Effect of Duodenal Acidification on the Gastric Secretory Response to Pentagastrin in Man

1972 • 7 citations

Histamine content in human gastric mucosa: Its relation to the pentagastrin-stimulated acid secretion and to selective-gastric vagotomy with drainage

1975 • 7 citations

Effect of Fatty Acids on the Stimulated Gastric Secretion in Man

1975 • 4 citations

Plasma Gastrin and Gastric Secretory Response to Duodenal Perfusion with Liver Extract in Healthy Human Subjects

1977 • 4 citations