The role of gut-associated lymphoid tissues and mucosal defence

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

2001 • 2,152 citations

Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin

1995 • 1,525 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.

1997 • 1,088 citations

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

1999 • 771 citations

Influences of microbiota on intestinal immune system development

1999 • 752 citations

Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

2001 • 693 citations

Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology

1998 • 660 citations

Dendritic cell lineage, plasticity and cross-regulation

2001 • 613 citations

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α⁺ DC correlates with unresponsiveness to imidazoquinolines

2003 • 544 citations

Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells

2002 • 544 citations

Development and Differences of Intestinal Flora in the Neonatal Period in Breast-Fed and Bottle-Fed Infants

1983 • 524 citations

Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants

2002 • 491 citations

Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine

2002 • 460 citations

Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance

2003 • 459 citations

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

2003 • 435 citations

Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

1999 • 370 citations

Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut

2003 • 353 citations

Administration of Transgalacto-Oligosaccharides Increases Fecal Bifidobacteria and Modifies Colonic Fermentation Metabolism in Healthy Humans

1997 • 333 citations

Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria

2002 • 329 citations

Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium

2002 • 306 citations

Antigen processing and presentation by intestinal epithelial cells – polarity and complexity

2000 • 292 citations

Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium lactis Modulates Intestinal Immune Functions in Rats

2004 • 276 citations

Toll-Like Receptor 4-Mediated Innate IL-10 Activates Antigen-Specific Regulatory T Cells and Confers Resistance toBordetella pertussisby Inhibiting Inflammatory Pathology

2003 • 263 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Increase in the Population of Duodenal Immunoglobulin A Plasmocytes in Axenic Mice Associated with Different Living or Dead Bacterial Strains of Intestinal Origin

1978 • 233 citations

Evidence for an Innate Immune Response in the Immature Human Intestine: Toll-Like Receptors on Fetal Enterocytes

2001 • 204 citations

Toll-like receptors and T-helper-1/T-helper-2 responses

2003 • 203 citations

Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction.

1982 • 157 citations

Microbial Colonization Drives Lymphocyte Accumulation and Differentiation in the Follicle-Associated Epithelium of Peyer’s Patches

2003 • 157 citations

Differences in Expression of Toll-Like Receptors and Their Reactivities in Dendritic Cells in BALB/c and C57BL/6 Mice

2002 • 156 citations

Absence of Toll-Like Receptor 4 Explains Endotoxin Hyporesponsiveness in Human Intestinal Epithelium

2001 • 152 citations

Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.

1991 • 151 citations

CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens.

1997 • 146 citations

Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice

1988 • 134 citations

Continuous culture selection of bifidobacteria and lactobacilli from human faecal samples using fructooligosaccharide as selective substrate

1998 • 133 citations

Differential Induction of Interleukin-10 and Interleukin-12 in Dendritic Cells by Microbial Toll-Like Receptor Activators and Skewing of T-Cell Cytokine Profiles

2003 • 128 citations

Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-κB and PPARα

2004 • 127 citations

Role of Oligosaccharides and Glycoconjugates in Intestinal Host Defense

2000 • 120 citations

The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice

1996 • 99 citations

Role of Oligosaccharides and Glycoconjugates in Intestinal Host Defense

2000 • 97 citations

Evolutionary perspective on innate immune recognition

2001 • 85 citations

Suppressor T cells: Rebirth, function and homeostasis

2000 • 80 citations

The role of indigenous microflora in the development of murine intestinal fucosyl‐ and sialyltransferases

2002 • 76 citations

Priming by Microbial Antigens from the Intestinal Flora Determines the Ability of CD4+ T Cells to Rapidly Secrete IL-4 in BALB/c Mice Infected withLeishmania major

2000 • 71 citations

Oligofructose contributes to the protective role of bifidobacteria in experimental necrotising enterocolitis in quails

1999 • 67 citations

Mode of Feeding and its Effect on Infant Mortality and Morbidity

1982 • 59 citations

The Neonatal Development of Intraepithelial and Lamina Propria Lymphocytes in the Murine Small Intestine

1996 • 58 citations