Altered chloride homeostasis in neurological disorders: a new target

Neuronal Plasticity: Increasing the Gain in Pain

2000 • 3,672 citations

Excitatory actions of gaba during development: the nature of the nurture

2002 • 2,322 citations

The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

1999 • 2,069 citations

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

2005 • 1,836 citations

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

2003 • 1,491 citations

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

2003 • 1,064 citations

On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro

2002 • 987 citations

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

1999 • 977 citations

NKCC1 transporter facilitates seizures in the developing brain

2005 • 940 citations

Cation–chloride co-transporters in neuronal communication, development and trauma

2003 • 816 citations

Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA _A Receptors

1995 • 800 citations

Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters

2005 • 763 citations

Innate immunity: the missing link in neuroprotection and neurodegeneration?

2002 • 695 citations

BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion

2002 • 531 citations

Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2

2004 • 494 citations

Immune and glial cell factors as pain mediators and modulators

2005 • 443 citations

Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

1999 • 434 citations

Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity

2003 • 419 citations

Abnormal GABA_AReceptor-Mediated Currents in Dorsal Root Ganglion Neurons Isolated from Na–K–2Cl Cotransporter Null Mice

2000 • 342 citations

Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord

1999 • 308 citations

Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride

2003 • 304 citations

Anomalous levels of Cl ⁻ transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory

2006 • 297 citations

BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2

2003 • 295 citations

The K–Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

2002 • 268 citations

Reduction of KCC2 Expression and GABA_AReceptor-Mediated Excitation after In Vivo Axonal Injury

2002 • 259 citations

Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission

2006 • 248 citations

NMDA receptors as targets for drug action in neuropathic pain

2001 • 229 citations

Modulation of GABAergic Transmission by Activity via Postsynaptic Ca2+-Dependent Regulation of KCC2 Function

2005 • 223 citations

WNK3 modulates transport of Cl ^- in and out of cells: Implications for control of cell volume and neuronal excitability

2005 • 210 citations

Instantaneous Perturbation of Dentate Interneuronal Networks by a Pressure Wave-Transient Delivered to the Neocortex

1997 • 201 citations

Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat

2002 • 198 citations

Brain-Derived Neurotrophic Factor Modulation of GABAergic Synapses by Postsynaptic Regulation of Chloride Transport

2003 • 193 citations

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices

2005 • 163 citations

Insulin-Like Growth Factor 1 and a Cytosolic Tyrosine Kinase Activate Chloride Outward Transport during Maturation of Hippocampal Neurons

2001 • 153 citations

Impaired Cl⁻Extrusion in Layer V Pyramidal Neurons of Chronically Injured Epileptogenic Neocortex

2005 • 147 citations

Induction of NMDA and GABA_AReceptor-Mediated Ca²⁺Oscillations With KCC2 mRNA Downregulation in Injured Facial Motoneurons

2003 • 131 citations

Brain injury impairs dentate gyrus inhibitory efficacy

2006 • 127 citations

Reduction of Anion Reversal Potential Subverts the Inhibitory Control of Firing Rate in Spinal Lamina I Neurons: Towards a Biophysical Basis for Neuropathic pain

2006 • 127 citations

Behavioural phenotypes of hypomorphic KCC2‐deficient mice

2005 • 127 citations

Responsiveness of rat substantia gelatinosa neurones to mechanical but not thermal stimuli revealed by in vivo patch‐clamp recording

1999 • 124 citations

Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue

2000 • 113 citations

In Vivo Patch-Clamp Analysis of IPSCs Evoked in Rat Substantia Gelatinosa Neurons by Cutaneous Mechanical Stimulation

2000 • 111 citations

Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity

2005 • 109 citations

The multiple facets of γ-aminobutyric acid dysfunction in epilepsy: review

2005 • 104 citations

A C-terminal Domain in KCC2 Confers Constitutive K+-Cl- Cotransport

2005 • 103 citations

Mutations in the K⁺/Cl⁻Cotransporter Genekazachoc(kcc) Increase Seizure Susceptibility inDrosophila

2006 • 93 citations

The action of BDNF on GABAA currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons

2003 • 89 citations

Pharmacological Isolation of the Synaptic and Nonsynaptic Components of the GABA-Mediated Biphasic Response in Rat CA1 Hippocampal Pyramidal Cells

1999 • 88 citations

Deafness Disrupts Chloride Transporter Function and Inhibitory Synaptic Transmission

2003 • 84 citations

Epileptogenic neurons and circuits.

1999 • 76 citations

Brain‐type creatine kinase activates neuron‐specific K⁺‐Cl^– co‐transporter KCC2

2005 • 76 citations

Role of the Na+-K+-2Cl⁻ Cotransporter in the Development of Capsaicin-Induced Neurogenic Inflammation

2006 • 68 citations

Expression and developmental regulation of the K+–Cl− cotransporter KCC2 in the cochlear nucleus

2005 • 38 citations

Diuretics as Antiepileptic Drugs: Should We Go with the Flow?

2002 • 23 citations

Heterogeneous chloride homeostasis and GABA responses in the median preoptic nucleus of the rat

2005 • 17 citations