Polygenic susceptibility to prostate and breast cancer: implications for personalised screening

Global cancer statistics

2011 • 55,498 citations

Global Cancer Statistics, 2002

2005 • 17,966 citations

Screening and Prostate-Cancer Mortality in a Randomized European Study

2009 • 3,866 citations

Mortality Results from a Randomized Prostate-Cancer Screening Trial

2009 • 2,828 citations

Genome-wide association study identifies novel breast cancer susceptibility loci

2007 • 2,342 citations

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

2007 • 1,102 citations

Multiple loci identified in a genome-wide association study of prostate cancer

2008 • 904 citations

Polygenic susceptibility to breast cancer and implications for prevention

2002 • 902 citations

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24

2007 • 872 citations

Multiple newly identified loci associated with prostate cancer susceptibility

2008 • 858 citations

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer

2007 • 793 citations

A common variant associated with prostate cancer in European and African populations

2006 • 784 citations

Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients

2007 • 749 citations

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

2007 • 726 citations

Genome-wide association study identifies five new breast cancer susceptibility loci

2010 • 694 citations

Cumulative Association of Five Genetic Variants with Prostate Cancer

2008 • 631 citations

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

2008 • 619 citations

A common coding variant in CASP8 is associated with breast cancer risk

2007 • 608 citations

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

2009 • 540 citations

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

2009 • 540 citations

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

2009 • 483 citations

Breast Cancer in Young Women: Poor Survival Despite Intensive Treatment

2009 • 462 citations

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

2008 • 458 citations

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

2009 • 420 citations

Performance of Common Genetic Variants in Breast-Cancer Risk Models

2010 • 410 citations

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

2008 • 372 citations

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

2009 • 349 citations

Multiple loci on 8q24 associated with prostate cancer susceptibility

2009 • 302 citations

Absolute Numbers of Lives Saved and Overdiagnosis in Breast Cancer Screeninq, from a Randomized Trial and from the Breast Screening Programme in England

2010 • 238 citations

Discriminatory Accuracy From Single-Nucleotide Polymorphisms in Models to Predict Breast Cancer Risk

2008 • 223 citations

Effect of Baseline Breast Density on Breast Cancer Incidence, Stage, Mortality, and Screening Parameters: 25-Year Follow-up of a Swedish Mammographic Screening

2010 • 181 citations

Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12

2008 • 170 citations

Treatment and survival outcomes in young men diagnosed with prostate cancer

2009 • 162 citations

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation

2009 • 115 citations

Maximising benefit and minimising harm of screening

2008 • 114 citations

Genome-wide association studies in cancer--current and future directions

2009 • 113 citations

Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

2009 • 107 citations

Age‐conditional probabilities of developing cancer

2003 • 101 citations

Overdiagnosis in Screening: Is the Increase in Breast Cancer Incidence Rates a Cause for Concern ?

2004 • 98 citations

Clinical utility of five genetic variants for predicting prostate cancer risk and mortality

2008 • 81 citations

Prostate-specific antigen testing accuracy in community practice

2002 • 73 citations

Mean sojourn time, overdiagnosis, and reduction in advanced stage prostate cancer due to screening with PSA: implications of sojourn time on screening

2009 • 70 citations

Association of Prostate Cancer Risk Variants with Clinicopathologic Characteristics of the Disease

2008 • 65 citations

Screening younger women with a family history of breast cancer – does early detection improve outcome?

2006 • 41 citations

Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease

2010 • 27 citations

[Detection of cancer, sensitivity of the test and sensitivity of the screening program].

1998 • 16 citations