Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis

The epithelial–mesenchymal transition: new insights in signaling, development, and disease

2006 • 1,987 citations

Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

1998 • 492 citations

Gap junctions and connexin-interacting proteins

2004 • 446 citations

Epithelial-mesenchymal transition

2005 • 417 citations

Positive selection of candidate tumor-suppressor genes by subtractive hybridization.

1991 • 320 citations

High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32

1997 • 290 citations

Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43).

1998 • 262 citations

Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential.

1996 • 254 citations

Connexin Family Members Target to Lipid Raft Domains and Interact with Caveolin-1

2002 • 246 citations

Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.

1992 • 245 citations

Host microenvironment in breast cancer development: Epithelial–mesenchymal transition in breast cancer development

2003 • 223 citations

Dual Functions for Connexins: Cx43 Regulates Growth Independently of Gap Junction Formation

2001 • 208 citations

Retroviral Delivery of Connexin Genes to Human Breast Tumor Cells Inhibits in Vivo Tumor Growth by a Mechanism That Is Independent of Significant Gap Junctional Intercellular Communication

2002 • 204 citations

Deficiency of connexin43 gap junctions is an independent marker for breast tumors.

1999 • 196 citations

Drebrin Is a Novel Connexin-43 Binding Partner that Links Gap Junctions to the Submembrane Cytoskeleton

2004 • 184 citations

The Gap Junction-independent Tumor-suppressing Effect of Connexin 43

2003 • 180 citations

CCN3 (NOV) Interacts with Connexin43 in C6 Glioma Cells

2004 • 150 citations

Use of Three-Dimensional Basement Membrane Cultures to Model Oncogene-Induced Changes in Mammary Epithelial Morphogenesis

2004 • 148 citations

Connexin-43 Interactions with ZO-1 and α- and β-tubulin

2001 • 147 citations

Connexin43 Interacts with NOV

2004 • 143 citations

Down-regulation of Cx43 by Retroviral Delivery of Small Interfering RNA Promotes an Aggressive Breast Cancer Cell Phenotype

2005 • 133 citations

Specificity of gap junction communication among human mammary cells and connexin transfectants in culture

1993 • 129 citations

Are tumours angiogenesis‐dependent?

2003 • 124 citations

The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.

2001 • 118 citations

Connexin45 Interacts with Zonula Occludens-1 and Connexin43 in Osteoblastic Cells

2001 • 101 citations

Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation

2004 • 99 citations

Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner

1998 • 98 citations

Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology.

2002 • 94 citations

Analysis of Multiple Gap Junction Gene Products in the Rodent and Human Mammary Gland

1995 • 89 citations

Functional Domain Mapping and Selective Trans-dominant Effects Exhibited by Cx26 Disease-causing Mutations

2004 • 85 citations

The Gap Junction Protein Connexin32 Is a Mouse Lung Tumor Suppressor

2004 • 84 citations

Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators

2002 • 83 citations

Role of catenins in the development of gap junctions in rat cardiomyocytes

2003 • 80 citations

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation

2003 • 79 citations

Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model

2005 • 77 citations

Gap Junction Distribution and Connexin Expression in Human Breast

1996 • 72 citations

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism

2006 • 60 citations

Interaction of monocytes with cocultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message.

1991 • 59 citations

Novel Rab GAP-like Protein, CIP85, Interacts with Connexin43 and Induces Its Degradation

2005 • 56 citations

Downregulation of connexin32 protein and gap-junctional intercellular communication by cytokine-mediated acute-phase response in immortalized mouse hepatocytes

1998 • 56 citations

The cochlear F-box protein OCP1 associates with OCP2 and connexin 26

2004 • 49 citations

Deficiency in the gap junction protein Connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner

2004 • 49 citations

Connexins in Tumour Suppression and Cancer Therapy

2007 • 47 citations

Connexin26 Regulates the Expression of Angiogenesis-Related Genes in Human Breast Tumor Cells by Both GJIC-Dependent and -Independent Mechanisms

2003 • 45 citations

Growth Inhibition by Connexin26 Expression in Cultured Rodent Tumor Cells

2002 • 18 citations

Connexin26 Regulates the Expression of Angiogenesis-Related Genes in Human Breast Tumor Cells by Both GJIC-Dependent and -Independent Mechanisms

2003 • 16 citations