Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways: dependent or independent of phosphatidylinositol 3-kinase

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

1997 • 1,444 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Regulation of protein kinase C

1997 • 919 citations

Respiratory burst in human neutrophils

1999 • 801 citations

Rapid Charcoal Assay for Intrinsic Factor (IF), Gastric Juice Unsaturated B12 Binding Capacity, Antibody to IF, and Serum Unsaturated B12 Binding Capacity

1965 • 743 citations

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

1975 • 653 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Control of exocytosis in early neutrophil activation.

1993 • 366 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes

1984 • 322 citations

The superoxide-forming enzymatic system of phagocytes

1988 • 315 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes

1983 • 241 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

Isoluminol-enhanced chemiluminescence: A sensitive method to study the release of superoxide anion from human neutrophils

1996 • 219 citations

Galectin-3 Activates the NADPH-Oxidase in Exudated but not Peripheral Blood Neutrophils

1998 • 199 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

Prevention of degradation of human polymorphonuclear leukocyte proteins by diisopropylfluorophosphate

1980 • 156 citations

Activation of the granule pool of the NADPH oxidase accelerates apoptosis in human neutrophils

1999 • 147 citations

D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate

1996 • 135 citations

Identification of intracellular sites of superoxide production in stimulated neutrophils

1998 • 131 citations

Antagonists of Phosphatidylinositol 3-Kinase Block Activation of Several Novel Protein Kinases in Neutrophils

1995 • 127 citations

Phorbol myristate acetate-induced NADPH oxidase activity in human neutrophils: only half the story has been told

1996 • 123 citations

Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate.

1981 • 121 citations

Protein kinase C-dependent and -independent activation of the NADPH oxidase of human neutrophils.

1991 • 120 citations

Phosphatidylinositol-3 Kinase Is Necessary for 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Transformation and Activated Protein 1 Activation

1997 • 112 citations

A Noninvasive Fluorimetric Procedure for Measurement of Membrane Potential

1999 • 106 citations

Human neutrophil gelatinase: A marker for circulating blood neutrophils. Purification and quantitation by enzyme linked immunosorbent assay

1992 • 101 citations

PI 3-Kinase-Dependent and Independent Chemotaxis of Human Neutrophil Leukocytes

1995 • 99 citations

Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils.

1997 • 97 citations

Identification and regulation of protein kinase C-delta in human neutrophils.

1996 • 91 citations

Activation of MEKK by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils

1996 • 88 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF.

1996 • 82 citations

Different Subcellular Localization of Cytochrome b and the Dormant NADPH-Oxidase in Neutrophils and Macrophages: Effect on the Production of Reactive Oxygen Species during Phagocytosis

1995 • 79 citations

Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase

1995 • 75 citations

Difference in extracellular radical release after chemotactic factor and calcium ionophore activation of the oxygen radical-generating system in human neutrophils

1987 • 72 citations

Cyclic AMP-increasing Agents Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3-Kinase Rather than Receptor-operated Ca2+ Influx

1995 • 69 citations

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

1982 • 69 citations

Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids.

1987 • 66 citations

Effect of Inhibitors of Distinct Signaling Pathways on Neutrophil O2− Generation in Response to Tumor Necrosis Factor-α, and Antibodies Against CD18 and CD11a: Evidence for a Common and Unique Pattern of Sensitivity to Wortmannin and Protein Tyrosine

1993 • 66 citations

Immunochemical identification and translocation of protein kinase C zeta in human neutrophils

1994 • 65 citations

Inhibition of neutrophil oxidative burst and granule secretion by Wortmannin: Potential role of MAP kinase and renaturable kinases

1997 • 65 citations

Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human Neutrophils

1996 • 62 citations

NADPH oxidase is functionally assembled in specific granules during activation of human neutrophils

1999 • 62 citations

Activation of the oxygen-radical-generating system in granules of intact human neutrophils by a calcium ionophore (ionomycin)

1992 • 58 citations

Superoxide, hydrogen peroxide and nitric oxide as signalling molecules: their production and role in disease.

1997 • 56 citations

Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcγ receptor cross-linking in human neutrophils

1997 • 49 citations

Protein kinase C isoforms in human neutrophil cytoplasts

1992 • 44 citations

Superoxide Production in Human Neutrophils: Evidence for Signal Redundancy and the Involvement of More Than One PKC Isoenzyme Class

1998 • 41 citations

Simultaneous calcium‐dependent delivery of neutrophil lactoferrin and reactive oxygen metabolites to erythrocyte targets: Evidence supporting granule‐dependent triggering of superoxide deposition

1993 • 33 citations

Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport

1996 • 29 citations

Quartz selectively down-regulates CR1 on activated human granulocytes

1993 • 26 citations

Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events

1996 • 24 citations

Activation of Human Neutrophils by Phorbol Ester Decreases the Cytoplasm Compactness and the Lactoferrin Content of the Granulocytes

1991 • 21 citations

Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils

1997 • 20 citations

Okadaic acid inhibits the signal responsible for activation of the NADPH-oxidase in neutrophils stimulated with serum-opsonized yeast

1996 • 16 citations

Inhibition of Protein Kinase C-Dependent Noradrenaline Release by Wortmannin in PC12 Cells

1997 • 13 citations

Wortmannin has opposite effects on phorbol ester‐induced DNA synthesis and phosphatidylcholine hydrolysis

1995 • 13 citations