Ghrelin as a Potential Anti-Obesity Target

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Central nervous system control of food intake

2000 • 6,305 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

Ghrelin Enhances Appetite and Increases Food Intake in Humans

2001 • 2,330 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

2003 • 1,665 citations

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

2003 • 1,617 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*

1999 • 1,467 citations

The Tissue Distribution of the mRNA of Ghrelin and Subtypes of Its Receptor, GHS-R, in Humans

2002 • 1,331 citations

Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin

2004 • 1,186 citations

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

1998 • 1,181 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

The Need to Feed

2002 • 1,089 citations

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 • 1,055 citations

Ghrelin and Des-acyl Ghrelin: Two Major Forms of Rat Ghrelin Peptide in Gastrointestinal Tissue

2000 • 924 citations

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

2002 • 734 citations

Multiple neural systems controlling food intake and body weight

2002 • 701 citations

Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa

2001 • 695 citations

Post-prandial decrease of circulating human ghrelin levels

2001 • 691 citations

Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration

2001 • 629 citations

Elevated plasma ghrelin levels in Prader–Willi syndrome

2002 • 604 citations

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

1999 • 592 citations

Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic Perspective

2001 • 556 citations

Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

2000 • 546 citations

Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects

2003 • 509 citations

Insulin Regulates Plasma Ghrelin Concentration

2002 • 500 citations

Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis

2001 • 479 citations

Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

2001 • 475 citations

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

2003 • 458 citations

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas

2002 • 449 citations

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

2002 • 394 citations

The Neuroanatomical Axis for Control of Energy Balance

2002 • 390 citations

Endocrine Dysfunction in Prader-Willi Syndrome: A Review with Special Reference to GH

2001 • 383 citations

Serum Ghrelin Levels Are Inversely Correlated with Body Mass Index, Age, and Insulin Concentrations in Normal Children and Are Markedly Increased in Prader-Willi Syndrome

2003 • 380 citations

The influence of insulin on circulating ghrelin

2003 • 368 citations

Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors

2002 • 347 citations

High Circulating Ghrelin: A Potential Cause for Hyperphagia and Obesity in Prader-Willi Syndrome

2002 • 343 citations

Kidney produces a novel acylated peptide, ghrelin

2000 • 336 citations

Identification, Characterization, and Biological Activity of Specific Receptors for Natural (Ghrelin) and Synthetic Growth Hormone Secretagogues and Analogs in Human Breast Carcinomas and Cell Lines1

2001 • 329 citations

Structural Divergence of Human Ghrelin

2002 • 326 citations

The Expression of the Growth Hormone Secretagogue Receptor Ligand Ghrelin in Normal and Abnormal Human Pituitary and Other Neuroendocrine Tumors1

2001 • 315 citations

GH, GH Receptor, GH Secretagogue Receptor, and Ghrelin Expression in Human T Cells, B Cells, and Neutrophils

2001 • 304 citations

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity

2002 • 290 citations

Ghrelin promotes slow-wave sleep in humans

2003 • 287 citations

Hemodynamic, Renal, and Hormonal Effects of Ghrelin Infusion in Patients with Chronic Heart Failure

2001 • 274 citations

Structure–Activity Relationship of Ghrelin: Pharmacological Study of Ghrelin Peptides

2001 • 245 citations

The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis

2003 • 233 citations

Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues

2002 • 221 citations

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

2002 • 215 citations

Insulin, Unlike Food Intake, Does Not Suppress Ghrelin in Human Subjects

2002 • 210 citations

Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin

2003 • 209 citations

Ghrelin in domestic animals: distribution in stomach and its possible role

2001 • 208 citations

Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans

2002 • 201 citations

Role of Ghrelin Polymorphisms in Obesity Based on Three Different Studies

2002 • 189 citations

CD36 Mediates the Cardiovascular Action of Growth Hormone-Releasing Peptides in the Heart

2002 • 169 citations

Loss of Meal-Induced Decrease in Plasma Ghrelin Levels in Patients with Anorexia Nervosa

2003 • 165 citations

Unnatural Growth Hormone-Releasing Peptide Begets Natural Ghrelin

2001 • 164 citations

Does the GH–IGF axis play a role in cancer pathogenesis?

2000 • 156 citations

Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells

2003 • 154 citations

A Variation in the Ghrelin Gene Increases Weight and Decreases Insulin Secretion in Tall, Obese Children

2002 • 152 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 151 citations

Ghrelin Can Bind to a Species of High Density Lipoprotein Associated with Paraoxonase

2003 • 149 citations

Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents

2002 • 146 citations

Leptin Transport Across the Blood-Brain Barrier: Implications for the Cause and Treatment of Obesity

2001 • 144 citations

Purification and Distribution of Ghrelin: The Natural Endogenous Ligand for the Growth Hormone Secretagogue Receptor

2001 • 143 citations

New Issues about Nitric Oxide and its Effects on the Gastrointestinal Tract

2001 • 138 citations

Cellular Warriors at the Battle of the Bulge

2003 • 126 citations

Ghrelin Gene: Identification of Missense Variants and a Frameshift Mutation in Extremely Obese Children and Adolescents and Healthy Normal Weight Students

2002 • 123 citations

Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy

2001 • 115 citations

The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer

2003 • 114 citations

Obesity therapy: altering the energy intake-and-expenditure balance sheet

2002 • 110 citations

The Antiproliferative Effect of Synthetic Peptidyl GH Secretagogues in Human CALU-1 Lung Carcinoma Cells

2002 • 110 citations

Beta3 -Adrenoceptor Agonists as Anti-diabetic and Anti-obesity Drugs in Humans

2001 • 107 citations

Ghrelin: a novel peptide for growth hormone release and feeding regulation

2002 • 104 citations

Improving body composition and physical activity in Prader-Willi Syndrome

2003 • 102 citations

Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia

2002 • 96 citations

Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients

2002 • 95 citations

Endocrine and Non-Endocrine Actions of Ghrelin

2003 • 94 citations

Hypophysectomy Prevents Ghrelin‐Induced Adiposity and Increases Gastric Ghrelin Secretion in Rats

2002 • 85 citations

Growth Hormone (GH)-Independent Stimulation of Adiposity by GH Secretagogues

2001 • 84 citations

Direct Peripheral Effects of Ghrelin Include Suppression of Adiponectin Expression

2002 • 84 citations

Effects of Neuropeptides and Leptin on Nutrient Partitioning: Dysregulations in Obesity

2001 • 64 citations

Hypothalamic and genetic obesity: an appraisal of the autonomic hypothesis and the endocrine hypothesis.

1984 • 58 citations

Differential Orexigenic Effects of Hexarelin and Its Analogs in the Rat Hypothalamus: Indication for Multiple Growth Hormone Secretagogue Receptor Subtypes

2000 • 53 citations

Ghrelin and motilin: two sides of one coin?

2001 • 51 citations

The genetics, diagnosis, and management of Prader-Willi Syndrome

2002 • 25 citations