Morphine induces apoptosis of human microglia and neurons

The biochemistry of apoptosis

2000 • 7,314 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Pathways to neuronal injury and apoptosis in HIV-associated dementia

2001 • 1,190 citations

Regenerating the damaged central nervous system

2000 • 824 citations

From bench to clinic with apoptosis-based therapeutic agents

2000 • 703 citations

Opiates inhibit neurogenesis in the adult rat hippocampus

2000 • 590 citations

The dynamics of CD4+ T-cell depletion in HIV disease

2001 • 576 citations

Apoptosis and the Nervous System

2000 • 469 citations

Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers

2000 • 421 citations

Opioids, opioid receptors, and the immune response

2001 • 398 citations

Caspase-8 and Caspase-3 Are Expressed by Different Populations of Cortical Neurons Undergoing Delayed Cell Death after Focal Stroke in the Rat

1999 • 261 citations

Neuronal cell death in nervous system development, disease, and injury (Review)

2001 • 256 citations

Apoptosis and neurologic disease

2000 • 255 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

Morphine Enhances Macrophage Apoptosis

1998 • 195 citations

Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

2001 • 164 citations

Human microglial cell defense against Toxoplasma gondii. The role of cytokines.

1994 • 159 citations

CYTOKINE-MEDIATED NEURONAL APOPTOSIS

1997 • 146 citations

Oligodendrocytes and Microglia Are Selectively Vulnerable to Combined Hypoxia and Hypoglycemia Injury in Vitro

1998 • 129 citations

Immunoregulatory effects of morphine on human lymphocytes

1997 • 104 citations

Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors.

1993 • 101 citations

Effects of opiates on neuronal development in the rat cerebral cortex

1993 • 96 citations

Mechanisms of Action of Drugs of Abuse on the Developing Fetal Brain

1999 • 94 citations

Morphine promotes apoptosis in Jurkat cells

1999 • 91 citations

Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical μ-opoid receptor

1999 • 63 citations

Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins

1997 • 59 citations

Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95)

1998 • 59 citations

Cyclic AMP Protects Against Staurosporine and Wortmannin‐Induced Apoptosis and Opioid‐Enhanced Apoptosis in Both Embryonic and Immortalized (F‐11κ7) Neurons

1998 • 56 citations

Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts

2000 • 56 citations

Morphine‐induced macrophage apoptosis: the role of transforming growth factor‐β

2000 • 52 citations

Proinflammatory cytokines inhibit HIV-1(SF162) expression in acutely infected human brain cell cultures.

1997 • 46 citations

Morphine-induced alterations in thymocyte subpopulations of B6C3F1 mice.

1993 • 44 citations

Immunomodulatory role of opioids in the central nervous system.

1997 • 37 citations

Morphine induces splenocyte apoptosis and enhanced mRNA expression of cathepsin-B.

1997 • 36 citations

Interleukin (IL)-1β-mediated apoptosis of human astrocytes

1999 • 35 citations

Prenatal morphine treatment and the development of the striatum

1994 • 23 citations

Morphine does not affect astrocyte survival in developing primary mixed-glial cultures

1993 • 19 citations

Chronic prenatal morphine treatment decreases Gαs mRNA levels in neonatal frontal cortex

1992 • 14 citations

NEW CONCEPTS IN THE IMMUNOPATHOGENESIS OF CNS INFECTIONS

2001 • 2 citations

Deleted Work

1955 • 0 citations