Islet Amyloid Polypeptide (IAPP) Transgenic Rodents as Models for Type 2 Diabetes

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1998 • 19,638 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

1998 • 8,603 citations

Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections

1998 • 6,746 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men

1994 • 1,842 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Emerging epidemic of type 2 diabetes in youth.

1999 • 1,051 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

1990 • 782 citations

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1999 • 600 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

2001 • 545 citations

Effects of Diabetes and Level of Glycemia on All-Cause and Cardiovascular Mortality: The San Antonio Heart Study

1998 • 484 citations

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1984 • 481 citations

Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes

2003 • 410 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats

2001 • 374 citations

Cushing's syndrome

2001 • 338 citations

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

1996 • 334 citations

Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans

1990 • 319 citations

High Prevalence of Hepatitis C Virus Infection in Diabetic Patients

1996 • 288 citations

Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat)

2004 • 260 citations

Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action

1986 • 232 citations

Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets

1989 • 185 citations

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

2003 • 183 citations

Diabetes, Impaired Fasting Glucose, and Elevated HbA1c in U.S. Adolescents: The Third National Health and Nutrition Examination Survey

2001 • 168 citations

Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat

1997 • 156 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

1999 • 153 citations

Alteration of Islet Cell Populations in Spontaneously Diabetic Mice

1978 • 147 citations

Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

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Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

1998 • 143 citations

Longitudinal studies on the development of diabetes in individual Macaca nigra

1986 • 137 citations

Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus

1989 • 124 citations

Replication Increases β-Cell Vulnerability to Human Islet Amyloid Polypeptide-Induced Apoptosis

2003 • 116 citations

Islet Amyloid Polypeptide: A Review of Its Biology and Potential Roles in the Pathogenesis of Diabetes Mellitus

1993 • 113 citations

Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

2003 • 110 citations

Nutritionally Induced Insulin Resistance and Receptor Defect Leading to β‐Cell Failure in Animal Models

1999 • 103 citations

Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice

2004 • 101 citations

Islet Amyloid Polypeptide in Human Insulinomas: Evidence for Intracellular Amyloidogenesis

1994 • 94 citations

Treatment With Growth Hormone and Dexamethasone in Mice Transgenic for Human Islet Amyloid Polypeptide Causes Islet Amyloidosis and β-Cell Dysfunction

1996 • 89 citations

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.

2001 • 87 citations

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Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat

1996 • 77 citations

Islet Amyloid Develops Diffusely Throughout the Pancreas Before Becoming Severe and Replacing Endocrine Cells

2001 • 75 citations

Diabetes mellitus in pancreatic cancer follow-up.

1994 • 72 citations

Pancreatic Islets of Obese Hyperglycemic Mice (ob/ob)

1992 • 70 citations

PSAMMOMYS OBESUS OF THE JERUSALEM COLONY: A MODEL FOR NUTRITIONALLY INDUCED, NON-INSULIN-DEPENDENT DIABETES

1993 • 66 citations

Comparison of Body Size Measurements as Predictors of NIDDM in Pima Indians

1995 • 57 citations

Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin

1995 • 52 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umea +/?)

1999 • 45 citations

Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice

1998 • 43 citations

The role of amylin in the insulin resistance of non-insulin-dependent diabetes mellitus

1990 • 41 citations

Human Islet Amyloid Polypeptide Accumulates at Similar Sites in Islets of Transgenic Mice and Humans

1994 • 38 citations

Imaging β-Cell Death With a Near-Infrared Probe

2005 • 37 citations

Contribution of Abnormal Insulin Secretion and Insulin Resistance to the Pathogenesis of Type 2 Diabetes in Myotonic Dystrophy

2003 • 37 citations

Isoproterenol-Stimulated C-Peptide and Insulin Secretion in Diabetic and Nonobese Normal Subjects: Decreased Hepatic Extraction of Endogenous Insulin in Diabetes

1980 • 37 citations

The effect of islet amyloid polypeptide (amylin) and calcitonin gene-related peptide on glucose removal in the anaesthetized rat and on insulin secretion from rat pancreatic isletsin vitro

1990 • 30 citations

Postmortem Autolysis in the Pancreas

1990 • 27 citations

Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic β cells

1997 • 26 citations

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice

2005 • 11 citations

Diabetes Mellitus and Preventable Spinal Cord Injury

2005 • 10 citations