Role of Systemic Inflammatory Response in Predicting Survival in Patients with Primary Operable Cancer

Inflammation and cancer

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Acute-Phase Proteins and Other Systemic Responses to Inflammation

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Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

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Prognostic effect of weight loss prior tochemotherapy in cancer patients

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Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer

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Systemic inflammation, nutritional status and survival in patients with cancer

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Cachexia: pathophysiology and clinical relevance1,2

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Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis

2006 • 744 citations

Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer

2003 • 724 citations

Elevated Biomarkers of Inflammation Are Associated With Reduced Survival Among Breast Cancer Patients

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Prognostic Factors in Advanced Cancer Patients: Evidence-Based Clinical Recommendations—A Study by the Steering Committee of the European Association for Palliative Care

2005 • 650 citations

Inflammation and necrosis promote tumour growth

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Neutrophil/lymphocyte ratio and its association with survival after complete resection in non–small cell lung cancer

2008 • 540 citations

Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment

2008 • 509 citations

Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer

2007 • 485 citations

Systemic inflammatory response predicts survival following curative resection of colorectal cancer

2003 • 446 citations

An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer

2008 • 438 citations

Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases

2007 • 438 citations

Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma

2008 • 435 citations

Risk factors for morbidity and mortality after colectomy for colon cancer

2000 • 405 citations

Preoperative Neutrophil‐to‐Lymphocyte Ratio as a Prognostic Predictor after Curative Resection for Hepatocellular Carcinoma

2008 • 396 citations

C-Reactive Protein: An Activator of Innate Immunity and a Modulator of Adaptive Immunity

2004 • 380 citations

Immune cells as mediators of solid tumor metastasis

2007 • 363 citations

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 360 citations

Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer

2004 • 341 citations

Evaluation of an inflammation‐based prognostic score in patients with metastatic renal cancer

2006 • 329 citations

Blood Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients with Colorectal Liver Metastases Treated with Systemic Chemotherapy

2009 • 317 citations

Acute-phase protein response and survival duration of patients with pancreatic cancer

1995 • 309 citations

Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer

2007 • 305 citations

Poor prognosis associated with thrombocytosis in patients with gastric cancer

2002 • 270 citations

The impact of preoperative serum C‐reactive protein on the prognosis of patients with hepatocellular carcinoma

2005 • 265 citations

Inflammation-Based Prognostic Score Is a Novel Predictor of Postoperative Outcome in Patients With Colorectal Cancer

2007 • 262 citations

Significance of preoperative elevation of serum C-reactive protein as an indicator for prognosis in colorectal cancer

1998 • 223 citations

The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

2005 • 220 citations

Preoperative Prognostic Score for Predicting Survival After Hepatic Resection for Colorectal Liver Metastases

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Serum C-Reactive Protein as Independent Prognostic Variable in Patients with Ovarian Cancer

2008 • 192 citations

Stimulation of tumour growth by wound-derived growth factors

1999 • 187 citations

Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma

2001 • 179 citations

Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma1

2004 • 172 citations

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss

1999 • 171 citations

Changes in Nutritional, Functional, and Inflammatory Markers in Advanced Pancreatic Cancer

1999 • 164 citations

Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer

2006 • 164 citations

Comparison of the Prognostic Value of Inflammation-Based Pathologic and Biochemical Criteria in Patients Undergoing Potentially Curative Resection for Colorectal Cancer

2009 • 161 citations

C‐reactive protein is an informative predictor of renal cell carcinoma‐specific mortality

2007 • 160 citations

An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer

2006 • 159 citations

Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

2008 • 154 citations

Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications

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A prospective study of tumor recurrence and the acute-phase response after apparently curative colorectal cancer surgery

1995 • 150 citations

Elevation of preoperative serum C‐reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma

2003 • 146 citations

Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas

2004 • 145 citations

Impact of pretreatment thrombocytosis on survival in primary breast cancer

2003 • 144 citations

Is serum albumin an independent predictor of survival in patients with breast cancer?

2003 • 143 citations

Prognostic Value of Thrombocytosis in Renal Cell Carcinoma

2006 • 131 citations

Preoperative C‐reactive protein as a prognostic and therapeutic marker for colorectal cancer

2008 • 130 citations

Significant Host- and Tumor-Related Factors for Predicting Prognosis in Patients With Esophageal Carcinoma

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Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

2000 • 118 citations

Serum albumin: a prognostic indicator in patients with colorectal cancer.

1998 • 117 citations

Longitudinal study of body cell mass depletion and the inflammatory response in cancer patients

1998 • 117 citations

Acute‐Phase Proteins or Tumour Markers: The Role of SAA, SAP, CRP and CEA as Indicators of Metastasis in a Broad Spectrum of Neoplastic Diseases

1984 • 117 citations

Prognostic factors in the palliation of pancreatic cancer

2003 • 116 citations

Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus

2006 • 111 citations

C-Reactive Protein as a Prognostic Variable That Reflects Uncontrolled Up-Regulation of the IL-1-IL-6 Network System in Colorectal Carcinoma

2004 • 111 citations

Cancer cachexia and targeting chronic inflammation: a unified approach to cancer treatment and palliative/supportive care.

2007 • 110 citations

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

2007 • 109 citations

Increased preoperative serum C‐reactive protein level predicts a poor prognosis in patients with localized renal cell carcinoma

2006 • 102 citations

C‐reactive protein as a prognostic marker for men with androgen‐independent prostate cancer

2008 • 102 citations

1120: Evaluation of an Inflammation Based Prognostic Score in Patients with Metastatic Renal Cancer

2007 • 101 citations

Preoperative Elevation of Serum C-Reactive Protein Is Related to Impaired Immunity in Patients With Colorectal Cancer

2000 • 99 citations

Are pretreatment serum albumin and cholesterol levels prognostic tools in patients with colorectal carcinoma?

2006 • 99 citations

The relationship between the systemic inflammatory response and survival in patients with transitional cell carcinoma of the urinary bladder

2005 • 98 citations

Serum C‐reactive protein levels predict survival in hepatocellular carcinoma

2007 • 97 citations

Preoperative serum C-reactive protein level in non-small cell lung cancer.

2007 • 96 citations

Outcome After Proctectomy for Rectal Cancer in Department of Veterans Affairs Hospitals

1998 • 96 citations

Prognostic Significance of C-Reactive Protein and Smoking in Patients with Advanced Non-small Cell Lung Cancer Treated with First-Line Palliative Chemotherapy

2009 • 96 citations

Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy

2009 • 94 citations

Development and External Validation of a New Outcome Prediction Model for Patients With Clear Cell Renal Cell Carcinoma Treated With Nephrectomy Based on Preoperative Serum C-Reactive Protein and TNM Classification: The TNM-C Score

2009 • 94 citations

Inflammation-based prognostic score, prior to neoadjuvant chemoradiotherapy, predicts postoperative outcome in patients with esophageal squamous cell carcinoma

2008 • 93 citations

Significance of thrombocytosis in patients with epithelial ovarian cancer

1994 • 93 citations

Prognostic Factors in Patients with Metastatic Pancreatic Adenocarcinoma Receiving Systemic Chemotherapy

2000 • 92 citations

Elevated serum levels of C-reactive protein are indicative of a poor prognosis in patients with esophageal cancer

2005 • 89 citations

Serum C-reactive protein as a prognostic factor in patients with epithelial ovarian cancer

1999 • 88 citations

The prognostic significance of thrombocytosis in epithelial ovarian carcinoma

2003 • 88 citations

The impact of preoperative serum C‐reactive protein on the prognosis of patients with upper urinary tract urothelial carcinoma treated surgically

2007 • 87 citations

Longitudinal Study of Weight, Appetite, Performance Status, and Inflammation in Advanced Gastrointestinal Cancer

1999 • 87 citations

Impact of thrombocytosis and C‐reactive protein elevation on the prognosis for patients with renal cell carcinoma

2006 • 83 citations

Circulating Haptoglobin Is an Independent Prognostic Factor in the Sera of Patients with Epithelial Ovarian Cancer

2007 • 81 citations

Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy.

2002 • 80 citations

Prospective study of the relationship between the systemic inflammatory response, prognostic scoring systems and relapse‐free and cancer‐specific survival in patients undergoing potentially curative resection for renal cancer

2008 • 80 citations

Acute-phase protein response, survival and tumour recurrence in patients with colorectal cancer

2001 • 80 citations

Evaluation of an inflammation-based prognostic score in patients with advanced ovarian cancer

2008 • 79 citations

Multivariate analyses as aids to diagnosis and assessment of prognosis in gastrointestinal cancer

1983 • 79 citations

The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer

2006 • 78 citations

Systemic Inflammatory Response, Prostate-Specific Antigen and Survival in Patients with Metastatic Prostate Cancer

2006 • 74 citations

Platelets counts closely correlate with the disease-free survival interval of pancreatic cancer patients.

2004 • 74 citations

Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer

2007 • 74 citations

Serum C-reactive protein correlates with survival in colorectal cancer patients but is not an independent prognostic indicator

2003 • 73 citations

C-reactive protein level predicts prognosis in patients with muscle-invasive bladder cancer treated with chemoradiotherapy

2008 • 71 citations

Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas

2009 • 70 citations

Thrombocytosis is Associated With a Significant Increase in the Cancer Specific Death Rate After Radical Nephrectomy

2002 • 69 citations

Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer

2009 • 68 citations

The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors

2008 • 67 citations

Prognostic impact of thrombocytosis in resectable non-small cell lung cancer

2008 • 63 citations

Inflammation and outcome after general thoracic surgery

2007 • 62 citations

Surgical technique and systemic inflammation influences long‐term disease‐free survival following hepatic resection for colorectal metastasis

2008 • 61 citations

Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer

2008 • 60 citations

Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases

2008 • 59 citations

C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma

2006 • 58 citations

Prognostic Value of Preoperative Peripheral Blood Monocyte Count in Patients with Colorectal Liver Metastasis after Liver Resection

2007 • 55 citations

Relationship between weight loss, reduction of body cell mass and inflammatory response in patients with cancer

1994 • 53 citations

Ovarian carcinoma associated thrombocytosis. Correlation with prognostic factors and with survival.

1998 • 53 citations

Clinical Significance of Platelet Count in Patients with Renal Cell Carcinoma

2007 • 52 citations

Significant Prognostic Factors for 5‐Year Survival after Curative Resection of Renal Cell Carcinoma

1998 • 51 citations

Significance of thrombocytosis for determining prognosis in patients with localized renal cell carcinoma

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Systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer

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Appraisal of a model for prediction of prognosis in advanced colorectal cancer

1994 • 46 citations

Correlation of C-Reactive Protein with Survival and Radiographic Response to First-Line Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer

2008 • 43 citations

Prognostic Significance of Thrombocytosis in Node-negative Colon Cancer

2005 • 42 citations

Prognostic significance of common preoperative laboratory variables in clear cell renal cell carcinoma

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Preoperative platelet count predicts survival after resection of periampullary adenocarcinoma.

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Pre-operative plasma levels of C-reactive protein, albumin and various plasma protease inhibitors for the pre-operative assessment of operability and recurrence in cancer surgery

1996 • 32 citations

Prognostic significance of thrombocytosis in renal cell carcinoma patients

2004 • 30 citations

Preoperative Predictors for Residual Tumor after Surgery in Patients with Ovarian Carcinoma

2007 • 30 citations

Simple Stratification of Survival Using Bone Scan and Serum C-Reactive Protein in Prostate Cancer Patients with Metastases

2008 • 25 citations

Prognostic importance of serum vascular endothelial growth factor in relation to platelet and leukocyte counts in human renal cell carcinoma

2002 • 25 citations

Correlation of Platelet Count With Second-Look Laparotomy Results and Disease Progression in Patients With Advanced Epithelial Ovarian Cancer

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Pretreatment prognostic factors in colorectal cancer patients with synchronous liver metastases.

1987 • 14 citations

Assessment of Acute Phase Proteins as Prognostic Factors in Patients Surgically Treated for Non-Small Cell Lung Cancer

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Importance of biologic status to the postoperative prognosis of patients with stage III nonsmall cell lung cancer

1987 • 10 citations