Dual mechanisms of regulation of type I iodothyronine 5'-deiodinase in the rat kidney, liver, and thyroid gland. Implications for the treatment of hyperthyroidism with radiographic contrast agents.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Assay of proteins in the presence of interfering materials

1976 • 3,217 citations

Comparing the Means of Several Groups

1985 • 750 citations

On the Evaluation of the Constants V _m and K _M in Enzyme Reactions

1952 • 746 citations

Iodothyronine Metabolism in Rat Liver Homogenates

1978 • 315 citations

A Study of Extrathyroidal Conversion of Thyroxine (T₄) to 3,3′,5-Triiodothyronine (T₃) in Vitro*

1977 • 289 citations

Pathways of Metabolism of Thyroid Hormones

1978 • 242 citations

Iodothyronine 5′-Deiodinase from Rat Kidney: Substrate Specificity and the 5′-Deiodination of Reverse Triiodothyr onine *

1980 • 231 citations

Changes of Circulating Thyroxine, Triiodothyronine and Reverse Triiodothyronine After Radiographic Contrast Agents

1976 • 193 citations

Enzymic parameters: Measurement of V and Km

1971 • 183 citations

Regulation of Rat Cerebrocortical and Adenohypophyseal Type II 5′-Deiodinase by Thyroxine, Triiodothyronine, and Reverse Triiodothyronine*

1985 • 160 citations

On the Evaluation of the Constants Vm and KM in Enzyme Reactions

1952 • 150 citations

Evidence for Two Tissue-specific Pathways for In Vivo Thyroxine 5′-Deiodination in the Rat

1982 • 143 citations

The Role of Thyroid Hormone Deiodination in the Regulation of Hypothalamo-Pituitary Function

1984 • 125 citations

Iodothyronine Metabolism in Liver and Kidney Homogenates from Hyperthyroid and Hypothyroid Rats*

1978 • 116 citations

Acute Posttranscriptional Regulation of Cerebrocortical and Pituitary Iodothyronine 5′-Deiodinases by Thyroid Hormone^*

1984 • 113 citations

Mechanisms governing the relative proportions of thyroxine and 3,5,3′-triiodothyronine in thyroid secretion

1984 • 85 citations

The Effects and Interactions of Substrates, Inhibitors, and the Cellular Thiol- Disulfide Balance on the Regulation of Type II Iodothyronine 5′-Deiodinase*

1988 • 81 citations

Comparison of Sodium Ipodate (Oragrafin) and Propylthiouracil in Early Treatment of Hyperthyroidism*

1982 • 75 citations

The Ontogeny of the Enzyme Systems for the 5′- and 5-Deiodination of Thyroid Hormones in Chick Embryo Liver*

1987 • 69 citations

Iodothyronine Deiodination Reaction Types in Several Rat Tissues: Effects of Age, Thyroid Status, and Glucocorticoid Treatment*

1984 • 69 citations

Thyroxine-5&-Deiodinase of Rat Thyroid, But Not that of Liver, Is Dependent on Thyrotropin*

1982 • 68 citations

Evidence against a Major Role of L-Thyroxine at the Pituitary Level: Studies in Rats Treated with Iopanoic Acid (Telepaque)*

1980 • 67 citations

Triiodothyronine Generation from Thyroxine in Human Thyroid: Enhanced Conversion in Graves’ Thyroid Tissue

1981 • 65 citations

The Effect of Repeated Administration of Ipodate (Oragrafin) in Hyperthyroidism*

1978 • 65 citations

The Effect of Iopanoic Acid on the Regulation of Thyrotropin Secretion in Euthyroid Subjects*

1980 • 64 citations

Contribution from local conversion of thyroxine to 3,5,3'-triiodothyronine to intracellular 3,5,3'-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium

1982 • 50 citations

Role of aminoacylation of histidyl-tRNA in the regulation of protein degradation in Chinese hamster ovary cells.

1980 • 50 citations

Treatment of Neonatal Hyperthyroidism due to Graves’ Disease with Sodium Ipodate*

1987 • 48 citations

COMPARATIVE EFFECTS OF SODIUM IPODATE AND IODIDE ON SERUM THYROID HORMONE CONCENTRATIONS IN PATIENTS WITH GRAVES' DISEASE

1985 • 44 citations

Long Term Treatment of Graves5 Hyperthyroidism with Sodium Ipodate*

1985 • 43 citations

Changes in the Particulate Subcellular Component of Hepatic Thyroxine-5&-Monodeiodinase in Hyperthyroid and Hypothyroid Rats*

1979 • 41 citations

Characterization of Thyrotropin-Induced Increase in Iodothyronine Monodeiodinating Activity in Mice*

1985 • 40 citations

The Contribution of Local Thyroxine Monodeiodination to Intracellular 3,5,3′-Triiodothyronine in Several Tissues of Hyper thyroid Rats at Isotopic Equilibrium*

1984 • 35 citations

Outer and Inner Ring Monodeiodination of Thyroxine by Dog Thyroid and Liver: A Comparative Study Using a Particulate Cell Fraction*

1982 • 30 citations

Diagnosis of hyperthyioidism

1978 • 29 citations

One enzyme for the 5′-deiodination of 3,3′,5′-triiodothyronine and 3′,5′-diiodothyronine in rat liver

1982 • 29 citations

Antithyroxine effects of some thyroxine analogues

1959 • 29 citations

Long Term Treatment of Graves' Disease with Iopanoic Acid (Telepaque)

1987 • 28 citations

The Effect of Some Iodine-Containing Radiocontrast Agents on Iodothyronine Secretion from the Perfused Canine Thyroid*

1982 • 27 citations

Iodothyronine 5’-Deiodinase in Brown Adipose Tissue: Thiol Activation and Propylthiouracil Inhibition*

1986 • 22 citations

Modulating Effect of Glutathione Disulfide on Thyroxine-5'-Deiodination by Rat Hepatocytes in Primary Culture: Effect of Glucose*

1983 • 21 citations

Thyroid T4 5′-deiodinase activity in normal and abnormal human thyroid glands

1984 • 21 citations

Effect of Pharmacological Quantities of Infused 3,3′,5′- Triiodothyronine on Thyroxine Monodeiodination to 3,5,3′-Triiodothyronine*

1980 • 20 citations

Effect of Hypothyroidism and Hyperthyroidism on Triiodothyronine Production in Perfused Rat Liver^*

1984 • 19 citations

Subcellular Localization of Thyroxine 5′-Deiodinase Activity in Bovine Anterior Pituitary*

1985 • 17 citations

Antimetabolic activity of 3,3',5'-triiodo-DL-thyronine in man.

1960 • 16 citations

INHIBITION OF THYROXINE ACTION BY 3,3′,5′-TRIIODOTHYRONINE^*

1959 • 15 citations

The Effect of Experimental Hyperthyroidism and Hypothyroidism on 5′-Monodeiodination of 3,3′5′-Triiodothyronine and 3′,5′-Diiodothyronine by Rat Liver and Kidney*

1982 • 15 citations

Thyroxine Entering the Thyroid Gland via the Vascular Bed May Leave the Gland as Triiodothyronines. Studies with Perfused Dog Thyroid Lobes*

1986 • 12 citations

THE EFFECT OFdl-3,3′,5′-TRIIODOTHYRONINE IN GRAVES' DISEASE

1959 • 12 citations

3,3′,5′-Triiodothyronine Inhibits Iodothyronine-5′ Deiodinating Activity Induced by 3,5,3′-Triiodothyronine at Equimolar Concentrations in Cultured Fetal Mouse Liver*

1986 • 10 citations

Diagnosis of hyperthyroidism

2003 • 5 citations

Long-term administration of iopanoic acid in a case of severe thyrotoxicosis factitia

1986 • 4 citations

Stimulation of thyroidal iodothyronine 5'-monodeiodinase by long-acting thyroid stimulator (LATS)

1987 • 3 citations