Prevention of Cyclosporine-Induced Nephrotoxicity with Pentoxifylline

Pharmacokinetics

1982 • 3,815 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

A Randomized Clinical Trial of Cyclosporine in Cadaveric Renal Transplantation

1983 • 467 citations

Pentoxifylline efficacy in the treatment of intermittent claudication: Multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients

1982 • 425 citations

Effect of cyclosporine administration on renal hemodynamics in conscious rats

1985 • 416 citations

THROMBOEMBOLIC COMPLICATIONS AND HAEMOSTATIC CHANGES IN CYCLOSPORIN-TREATED CADAVERIC KIDNEY ALLOGRAFT RECIPIENTS

1985 • 333 citations

Cyclosporin-induced endothelial cell injury.

1986 • 331 citations

Cyclosporine nephrotoxicity

1986 • 323 citations

EVIDENCE THAT RENAL PROSTAGLANDIN AND THROMBOXANE PRODUCTION IS STIMULATED IN CHRONIC CYCLOSPORINE NEPHROTOXICITY

1987 • 167 citations

Cyclosporine A enhances platelet aggregation

1987 • 133 citations

Serum Cyclosporine Concentration and Risk of Acute Graft-versus-Host Disease after Allogeneic Marrow Transplantation

1988 • 126 citations

PHARMACOKINETIC PROFILES OF CYCLOSPORINE IN RATS

1985 • 109 citations

CYCLOSPORINE SUPPRESSION OF ENDOTHELIAL PROSTACYCLIN GENERATION

1988 • 105 citations

Effect of Cyclosporin A on prostacyclin synthesis by vascular tissue

1983 • 102 citations

Pentoxifylline in acute nonhemorrhagic stroke. A randomized, placebo-controlled double-blind trial.

1988 • 81 citations

Pharmacology of Pentoxifylline A Hemorheologic Agent for the Treatment of Intermittent Claudication

1984 • 77 citations

Acute cyclosporine A nephrotoxicity in rats: which role for renin-angiotensin system and glomerular prostaglandins?

1986 • 65 citations

The release of prostacyclin (PGI2) by pentoxifylline from human vascular tissue.

1982 • 59 citations

Pathogenetic mechanisms of nephrotoxicity: insights into cyclosporine nephrotoxicity.

1985 • 57 citations

Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin‐A

1983 • 57 citations

USE OF THE ISOLATED PERFUSED KIDNEY MODEL TO ASSESS THE ACUTE PHARMACOLOGIC EFFECTS OF CYCLOSPORINE AND ITS VEHICLE, CREMOPHOR EL

1987 • 55 citations

CHARACTERISTICS OF CYCLOSPORINE INDUCTION OF INCREASED PROSTAGLANDIN LEVELS FROM HUMAN PERIPHERAL BLOOD MONOCYTES

1984 • 52 citations

Preventive Treatment of Cerebral Transient Ischemia: Comparative Randomized Trial of Pentoxifylline versus Conventional Antiaggregants

1985 • 50 citations

Reduced platelet aggregation by pentoxifylline stimulated prostacyclin release.

1981 • 50 citations

EFFECTS OF THE PROSTAGLANDIN E1 ANALOG MISOPROSTOL ON CYCLOSPORINE NEPHROTOXICITY

1988 • 49 citations

Evidence for chronic platelet hyperaggregability and in vivo activation in cyclosporin-treated renal allograft recipients

1988 • 46 citations

EFFECTS OF CYCLOSPORINE ON THE ISOLATED PERFUSED RAT KIDNEY

1987 • 43 citations

Antagonist capacities of nifedipine, captopril, phenoxybenzamine, prostacyclin and indomethacin on cyclosporin A induced impairment of rat renal function

1986 • 43 citations

Cyclosporine Concentration Determinations for Monitoring and Pharmacokinetic Studies

1986 • 37 citations

CYCLOSPORINE IN ALLOGENEIC BONE MARROW TRANSPLANTATION

1986 • 36 citations

Effects of pentoxifylline in experimental acute renal failure

1989 • 35 citations

Pentoxifylline improves tissue oxygenation after hemorrhagic shock.

1987 • 34 citations

PGE2 reduces nephrotoxicity and immunosuppression of cyclosporine in rats.

1986 • 30 citations

ENHANCEMENT OF PROCOAGULANT ACTIVITY IN STIMULATED MONONUCLEAR BLOOD CELLS AND MONOCYTES BY CYCLOSPORINE

1987 • 30 citations

Time-Dependent Pharmacokinetics and Toxicity of cyclosporine

1988 • 24 citations

Prevention of acute cyclosporine A nephrotoxicity by a thromboxane synthetase inhibitor.

1988 • 24 citations

Cyclosporine Pharmacokinetics and Blood Level Monitoring

1985 • 22 citations

Prevention of cyclosporine (CyA) nephrotoxicity by synthetic prostaglandins.

1986 • 20 citations

Cyclosporine disposition in the hyperlipidemic rat model.

1988 • 19 citations

THE SYNERGISTIC EFFECT OF CYCLOSPORINE AND ILOPROST ON SURVIVAL OF RAT CARDIAC ALLOGRAFTS

1986 • 18 citations

Determination of pentoxifylline and a major metabolite, 3,7-dimethyl-1-(5′-hydroxyhexyl)xanthine, by high-performance liqid chromatography

1986 • 18 citations

Fish oil vehicle for cyclosporine lowers renal thromboxanes and reduces experimental nephrotoxicity.

1987 • 14 citations

Different pharmacokinetics of cyclosporine A early and late after renal transplantation.

1988 • 11 citations

Cyclosporine pharmacokinetics and pharmacodynamics after oral administration in the rat.

1988 • 8 citations

Rheological action of oxpentifylline and structurally related xanthine derivatives on human erythrocytes

2016 • 8 citations

Effect of pentoxifylline on neutrophil behaviour: stimulation of movement without adhesion changes.

1988 • 8 citations

Pharmacokinetics of pentoxifylline during concomitant theophylline administration to rats.

1987 • 7 citations

Effect of a stable analogue of prostacyclin on cyclosporine A-induced nephrotoxicity: morphological qualitative and quantitative studies.

1988 • 7 citations

Cyclosporine A nephrotoxicity in Goldblatt renovascular hypertension in rats.

1986 • 6 citations

[Criteria for hemostasis in kidney transplant patients. Comparison of patients undergoing immunosuppression with cyclosporin and azathioprine steroids].

1984 • 6 citations

Patient decision-making for pancreatic transplantation.

1988 • 3 citations