Major attenuation of food reward with performance-sparing doses of pimozide in the rat.

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

1954 • 3,047 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

Dopamine Receptors in the Brain

1975 • 528 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine

1971 • 480 citations

The pathogenesis of Parkinson's disease: a new hypothesis.

1962 • 337 citations

Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficits

1976 • 320 citations

Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: Evidence for mediation by motor deficits rather than by reduced reward

1976 • 227 citations

Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide

1973 • 210 citations

Neuroleptic attenuation of intracranial self-stimulation: Reward or performance deficits?

1978 • 95 citations

The role of adaptive regulation in the pathophysiology of psychiatric disease

1974 • 7 citations