Variants in the Calpain-10 Gene Predispose to Insulin Resistance and Elevated Free Fatty Acid Levels

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1985 • 29,733 citations

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

A General Test of Association for Quantitative Traits in Nuclear Families

2000 • 1,160 citations

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

1989 • 799 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM

1997 • 465 citations

Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects

1996 • 374 citations

Calpain: A Protease in Search of a Function?

1998 • 352 citations

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

2000 • 295 citations

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

1984 • 291 citations

Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle

1993 • 251 citations

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

2000 • 239 citations

The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study

1997 • 236 citations

Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom

2001 • 191 citations

A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.

1993 • 160 citations

A New Subfamily of Vertebrate Calpains Lacking a Calmodulin-Like Domain: Implications for Calpain Regulation and Evolution

1997 • 136 citations

Role of calpain in adipocyte differentiation

1999 • 104 citations

Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects

1996 • 99 citations

The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease

1996 • 48 citations

Activation of a D‐form of rabbit muscle glycogen synthase by Ca²⁺‐activated protease

1986 • 6 citations