Neuroimmunomodulation in the Gastrointestinal Tract

Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer's patches, mesenteric lymph nodes, and spleen.

1986 • 579 citations

TYPES OF NERVES IN THE ENTERIC NERVOUS SYSTEM

1980 • 556 citations

Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves.

1987 • 554 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Mast cell heterogeneity: effects of neuroenteric peptides on histamine release.

1985 • 440 citations

Mast cells are closely apposed to nerves in the human gastrointestinal mucosa

1989 • 439 citations

G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides

1990 • 428 citations

Innervation of the Gastrointestinal Tract

1979 • 345 citations

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.

1988 • 281 citations

Interaction of vasoactive intestinal peptide with mouse lymphocytes: specific binding and the modulation of mitogen responses.

1984 • 266 citations

Substance P recognition by a subset of human T lymphocytes.

1984 • 258 citations

Projections of peptide-containing neurons in rat small intestine

1987 • 245 citations

Release of vasoactive intestinal polypeptide in mast cells by histamine liberators

1978 • 241 citations

Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases

1987 • 225 citations

Peptides encoded by the calcitonin gene inhibit macrophage function.

1989 • 208 citations

In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells.

1984 • 189 citations

Activation of macrophages by substance P: Induction of oxidative burst and thromboxane release

1983 • 185 citations

Inhibition by somatostatin of the proliferation of T-lymphocytes and Molt-4 lymphoblasts

1984 • 180 citations

Distribution of substance P receptors on murine spleen and Peyer's patch T and B cells.

1987 • 174 citations

Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts.

1984 • 173 citations

Neurobiology of the intestinal mucosa

1986 • 172 citations

Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease

1980 • 172 citations

Neuropeptide Regulation of Mucosal Immunity

1987 • 170 citations

Distinct Subsets of Somatostatin Receptors on Cultured Human Lymphocytes

1989 • 166 citations

Specific binding sites for vasoactive intestinal polypeptide on nonadherent peripheral blood lymphocytes.

1983 • 158 citations

Identification of Human Mononuclear Leukocytes Bearing Receptors for Somatostatin and Glucagon

1981 • 157 citations

The Neuropeptide Substance P Stimulates Production of Interleukin 1 in Human Blood Monocytes: Activated Cells are Preferentially Influenced by the Neuropeptide

1990 • 152 citations

Activation of human neutrophils by substance P. Effect on oxidative metabolism, exocytosis, cytosolic Ca2+ concentration and inositol phosphate formation.

1988 • 145 citations

Projections of peptide-containing neurons in rat colon

1988 • 139 citations

Receptors for sensory neuropeptides in human inflammatory diseases: Implications for the effector role of sensory neurons

1989 • 138 citations

In vivo immunomodulation by the neuropeptide substance P.

1988 • 136 citations

Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase.

1981 • 136 citations

Migration and homing of lymphoid cells

1988 • 136 citations

Modification of lymphocyte traffic by vasoactive neurotransmitter substances.

1984 • 135 citations

Increased levels of substance P in the myenteric plexus of Trichinella-infected rats

1992 • 135 citations

Selective effects of vasoactive intestinal peptide on the mitogenic response of murine T cells.

1987 • 133 citations

Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.

1988 • 126 citations

Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts.

1985 • 125 citations

The effects of vasoactive intestinal peptide on human natural killer cell function.

1985 • 124 citations

Peptide-containing nerve fibres in the gut wall in Crohn's disease.

1983 • 117 citations

Leukocytes in the intestinal epithelium: an unusual immunological compartment

1985 • 113 citations

Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide.

1990 • 113 citations

Inhibition of mouse T‐cell proliferation by CGRP and VIP: Effects of these neuropeptides on IL‐2 production and cAMP synthesis

1991 • 110 citations

Distinct subpopulations of enteric p-type neurones contain substance P and vasoactive intestinal polypeptide

1981 • 98 citations

Demonstration of a functional receptor for vasoactive intestinal polypeptide on Molt 4b T lymphoblasts

1983 • 94 citations

Neuropeptides Modulating Macrophage Function

1987 • 89 citations

Binding of vasoactive intestinal polypeptide (VIP) by human blood monocytes: demonstration of specific binding sites

1985 • 89 citations

Remodeling of B-50 (GAP-43)- and NSE-immunoreactive mucosal nerves in the intestines of rats infected with Nippostrongylus brasiliensis

1991 • 87 citations

The effect of substance P on the regional lymph node antibody response to antigenic stimulation in capsaicin-pretreated rats.

1987 • 87 citations

Multiple intracellular signaling pathways of the neuropeptide substance P receptor

1992 • 79 citations

Neuropeptide Function in the Gastrointestinal Tract

2019 • 76 citations

Changes in expression of autonomic nerves in aging and disease

1990 • 74 citations

Identification of high affinity receptors for vasoactive intestinal peptide on human lymphocytes of B cell lineage.

1989 • 74 citations

Vasoactive intestinal peptide-containing nerves in Peyer's patches

1987 • 69 citations

Nerve Remodelling during Intestinal Inflammationa

1992 • 69 citations

Interleukin 1β-induced increase in substance P in rat myenteric plexus

1993 • 60 citations

Vasoactive intestinal peptide stimulates T lymphocytes to release IL-5 in murine schistosomiasis mansoni infection.

1992 • 59 citations

Gastrointestinal regulatory peptides modulate in vitro immune reactions of mouse lymphoid cells

1986 • 58 citations

Vasoactive intestinal peptide inhibits the respiratory burst in human monocytes by a cyclic AMP-mediated mechanism

1989 • 56 citations

Effect of cholecystokinin and of its antagonist, of atropine, and of food on the release of immunoglobulin A and immunoglobulin G specific antibodies in the rat intestine

1987 • 54 citations

Conditioned medium from activated splenocytes increases substance P in sympathetic ganglia

1990 • 52 citations

Substance P increases lymphocyte traffic and lymph flow through peripheral lymph nodes of sheep.

1989 • 50 citations

The murine IgA-secreting plasmacytoma MOPC-315 expresses somatostatin receptors.

1988 • 49 citations

Endogenous somatostatin-like peptides of rat basophilic leukemia cells.

1985 • 49 citations

Selective modulation of the natural killer activity of murine intestinal intraepithelial leucocytes by the neuropeptide substance P.

1990 • 48 citations

High-affinity receptors for vasoactive intestinal peptide on human myeloma cells.

1989 • 48 citations

Depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (VIP).

1988 • 44 citations

Inhibition of murine intestinal inflammation by anti-substance P antibody.

1993 • 42 citations

Identification of lymphoid cell lines bearing receptors for somatostatin.

1987 • 41 citations

Effects of capsaicin treatment on immunoglobulin secretion in the rat: further evidence for involvement of tachykinin-containing afferent nerves

1990 • 41 citations

The interactions of neuropeptides with membrane model systems: A case study

1992 • 41 citations

Substance P activates and modulates neutrophil oxidative metabolism and aggregation.

1989 • 38 citations

Somatostatin: Historical Aspects

1986 • 38 citations

Are lymphocytes a target for substance P modulation in arthritis?

1992 • 32 citations

Binding of substance P to monolayers and vesicles made of phosphatidylcholine and/or phosphatidylserine

1992 • 31 citations

Immunomodulatory activities of the somatostatin analogue BIM 23014c: effects on murine lymphocyte proliferation and natural killer activity

1991 • 27 citations

Human intraepithelial lymphocytes

1991 • 26 citations

Tachykinin-mediated modulation of the primary antibody response in rats: evidence for mediation by an NK-2 receptor

1991 • 26 citations

Eosinophil chemotactic response to rat CGRP-1 is increased after exposure to trypsin or guinea-pig lung particulate fraction

1989 • 25 citations

The differential effect with time of neuropeptides on the proliferative responses of murine Peyer's patch and splenic lymphocytes

1987 • 23 citations

Electron microscopic study on the innervation of Peyer's patches of the Syrian hamster

1972 • 19 citations

Gastrointestinal neuropeptides suppress human colonic lamina propria lymphocyte DNA synthesis

1990 • 15 citations

Effect of VIP on the respiratory burst in human monocytes ex vivo during prolonged strain and energy deficiency

1989 • 14 citations

The Effect of Substance P on Neutrophil Function in Normal and Asthmatic Subjectsa

1992 • 9 citations

Synoviocyte derived granulocyte macrophage colony stimulating factor mediates the survival of human lymphocytes.

1992 • 8 citations

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