Iron Regulates Hyperoxia-Dependent Human Heme Oxygenase 1 Gene Expression in Pulmonary Endothelial Cells

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Iron Homeostasis, Oxidative Stress, and DNA Damage

1997 • 557 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.

1990 • 382 citations

Normobaric Oxygen Toxicity of the Lung

1980 • 375 citations

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

1996 • 348 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.

1991 • 305 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts.

1987 • 225 citations

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

1998 • 213 citations

Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury.

1996 • 210 citations

Developmental aspects of experimental pulmonary oxygen toxicity

1991 • 194 citations

Bilirubin attenuates radical‐mediated damage to serum albumin

1993 • 176 citations

Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin.

1995 • 170 citations

ATP-dependent Regulation of Sodium-Calcium Exchange in Chinese Hamster Ovary Cells Transfected with the Bovine Cardiac Sodium-Calcium Exchanger

1995 • 160 citations

Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals.

1994 • 153 citations

Structural organization of the human heme oxygenase gene and the function of its promoter

1989 • 143 citations

Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury.

1992 • 132 citations

Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene.

1994 • 130 citations

Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL

1996 • 86 citations

Oxygen Therapy

1980 • 85 citations

Isolation and culture of pulmonary endothelial cells.

1984 • 81 citations

Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo.

1995 • 76 citations

The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants

1993 • 62 citations

Variable glutathione levels and expression of antioxidant enzymes in human endothelial cells

1993 • 58 citations

Effect of oxygen and endotoxin on lactate dehydrogenase release, 5‐hydroxytryptamine uptake, and antioxidant enzyme activities in endothelial cells

1985 • 56 citations

Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25

1994 • 46 citations

Role of iron in ischemia-reperfusion oxidative injury of rat lungs.

1997 • 42 citations

Oxygen-mediated impairment of human pulmonary endothelial cell growth: evidence for a specific threshold of toxicity.

1989 • 25 citations

Isolation and maintenance of human pulmonary artery endothelial cells in culture isolated from transplant donors

1994 • 23 citations

Hyperoxic inhibition of newborn rat lung development: Protection by deferoxamine

1991 • 22 citations

Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells

1996 • 14 citations

Effect of ICRF-187 on the pulmonary damage induced by hyperoxia in the rat

1992 • 12 citations

Deleted Work

1955 • 0 citations