Olfactory function in apoE knockout mice

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1997 • 1,868 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Olfactory Deficits in Patients With Mild Cognitive Impairment Predict Alzheimer’s Disease at Follow-Up

2000 • 508 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Presence of both odor identification and detection deficits in alzheimer's disease

1987 • 477 citations

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

1982 • 420 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

1985 • 352 citations

Olfactory thresholds are associated with degree of dementia in Alzheimer's disease

1990 • 319 citations

Impaired olfaction as a marker for cognitive decline

1999 • 289 citations

The nature and course of olfactory deficits in Alzheimer's disease

1991 • 273 citations

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

1995 • 218 citations

Olfactory bulb changes in Alzheimer's disease

1987 • 189 citations

Odor identification as an early marker for Alzheimer's disease: Impact of lexical functioning and detection sensitivity

1995 • 186 citations

Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology

2001 • 158 citations

SELECTIVE OLFACTORY DEFICITS IN CASE H.M.

1983 • 156 citations

Loss of Olfactory Function in Dementing Disease

1999 • 152 citations

Very Early Changes in Olfactory Functioning Due to Alzheimer's Disease and the Role of Apolipoprotein E in Olfaction^a

1998 • 148 citations

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

1997 • 142 citations

Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain

2001 • 129 citations

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe^−/−Mice: Possible Role in Behavioral and Metabolic Alterations

2000 • 127 citations

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

1998 • 120 citations

Apolipoprotein E Status is Associated with Odor Identification Deficits in Nondemented Older Persons^a

1998 • 118 citations

Impaired sensory and cognitive olfactory function in questionable Alzheimer's disease.

1996 • 111 citations

Olfactory bulb removal vs peripherally induced anosmia: Differential effects on the aggressive behavior of male mice

1972 • 89 citations

Differential expression of apolipoprotein D and apolipoprotein E in the kainic acid-lesioned rat hippocampus

1997 • 85 citations

Olfactory bulb lesions in alzheimer's disease

1992 • 74 citations

Olfactory identification and apolipoprotein E ε4 allele in mild cognitive impairment

2002 • 73 citations

Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

1999 • 73 citations

Odor Memory in Normal Aging and Alzheimer's Disease^a

1998 • 71 citations

Dissociation of apolipoprotein and apolipoprotein receptor response to lesion in the rat brain: An in situ hybridization study

1998 • 55 citations

Apolipoprotein-E deficiency results in an altered stress responsiveness in addition to an impaired spatial memory in young mice

1998 • 49 citations

Social organization and aggression in a group of olfactory bulbectomized male mice

1996 • 48 citations

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice

1998 • 44 citations

Biochemical and cognitive studies of apolipoprotein-E-deficient mice

1996 • 43 citations

Apolipoprotein E Is Upregulated in Olfactory Bulb Glia Following Peripheral Receptor Lesion in Mice

2001 • 39 citations

Utility of Olfactory Identification Test for Diagnosing Chinese Patients With Alzheimer's Disease

2002 • 38 citations

Apolipoprotein E ε4 positive individuals demonstrate delayed olfactory event-related potentials

2001 • 34 citations

Behavioral deficits in APPV717F transgenic mice decient for the apolipoprotein E gene

2000 • 33 citations

Apolipoprotein E immunoreactivity in human and mouse olfactory bulb

1999 • 33 citations

Odor-cued taste avoidance: A simple and efficient method for assessing olfactory detection, discrimination and memory in the rat

1994 • 30 citations

Increased Density of Olfactory Receptor Neurons Immunoreactive for Apolipoprotein E in Patients with Alzheimer's Disease

1998 • 19 citations

Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain

2001 • 18 citations

Apolipoprotein E-deficient mice are not more susceptible to the biochemical and memory deficits induced by nucleus basalis lesion

2000 • 13 citations