Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma.
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References (47)
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 • 5,133 citations
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
1991 • 4,682 citations
BCL-2 family members and the mitochondria in apoptosis
1999 • 3,657 citations
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
1993 • 3,465 citations
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 • 3,130 citations
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
1983 • 1,808 citations
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
1998 • 1,394 citations
Induction of Apoptosis by Cancer Chemotherapy
2000 • 1,239 citations
The inhibitors of apoptosis (IAPs) and their emerging role in cancer
1998 • 985 citations
More than one way to die: apoptosis, necrosis and reactive oxygen damage
1999 • 850 citations
Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.
1997 • 749 citations
Oxidants in mitochondria: from physiology to diseases
1995 • 543 citations
Chimeric Anti-CD20 (IDEC-C2B8) Monoclonal Antibody Sensitizes a B Cell Lymphoma Cell Line to Cell Killing by Cytotoxic Drugs
1997 • 411 citations
Molecular mechanisms involved in cisplatin cytotoxicity
2000 • 380 citations
Low-Dose Compared with Standard-Dose m-BACOD Chemotherapy for Non-Hodgkin's Lymphoma Associated with Human Immunodeficiency Virus Infection
1997 • 379 citations
Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs.
2001 • 293 citations
Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis.
2001 • 287 citations
Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family
1995 • 279 citations
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.
1997 • 183 citations
Low-Dose Chemotherapy With Central Nervous System Prophylaxis and Zidovudine Maintenance in AIDS-Related Lymphoma
1991 • 174 citations
Prognostic factors in the treatment of human immunodeficiency virus-associated non-Hodgkin's lymphoma: analysis of AIDS Clinical Trials Group protocol 142--low-dose versus standard-dose m-BACOD plus granulocyte-macrophage colony-stimulating factor. National Institute of Allergy and Infectious Diseases.
1998 • 164 citations
Modulation of cis-diamminedichloroplatinum(II) resistance: a review
1992 • 161 citations
Human immunodeficiency virus-related lymphoma treatment with intensive combination chemotherapy
1993 • 155 citations
Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin
1985 • 154 citations
Apoptosis: checkpoint at the mitochondrial frontier
1999 • 152 citations
Apoptosis
1999 • 140 citations
Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma
1999 • 140 citations
Cisplatin resistance and oncogenes - a review
2000 • 116 citations
Nonclassical Platinum Antitumor Agents: Perspectives for Design and Development of New Drugs Complementary to Cisplatin
1993 • 113 citations
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma
2000 • 104 citations
Protein translocation in apoptosis
1999 • 96 citations
Induction of apoptosis in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
1997 • 90 citations
Bcl-2 family proteins: regulators of chemoresistance in cancer
1995 • 89 citations
A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils
1982 • 88 citations
Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression
2000 • 74 citations
Potentiation of fludarabine cytotoxicity on non-Hodgkin's lymphoma by pentoxifylline and rituximab.
2000 • 71 citations
Modulation of NF-κB, p53 and Bcl-2 in apoptosis induced by cisplatin in HeLa cells
1997 • 66 citations
Identification of genes differentially expressed in association with acquired cisplatin resistance
2000 • 62 citations
Molecules and Mechanisms
1995 • 59 citations
Mitochondria and apoptosis: HQ or high-security prison?
1999 • 53 citations
Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ-cell tumor cell line NT2, as quantitated by flow cytometry
1997 • 52 citations
A portrait of the Bcl-2 protein family: life, death, and the whole picture.
1999 • 50 citations
Involvement of the mitochondrion respiratory chain in the synergy achieved by treatment of human ovarian carcinoma cell lines with both tumor necrosis factor-alpha and cis-diamminedichloroplatinum.
1996 • 37 citations
Cisplatin inhibits the expression of X-chromosome-linked inhibitor of apoptosis protein in an oral carcinoma cell line
2001 • 29 citations
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin
1999 • 27 citations
Cisplatin resistance in cyclic AMP-dependent protein kinase mutants
1998 • 21 citations
Prognostic Factors in the Treatment of Human Immunodeficiency Virus-Associated Non-Hodgkin’s Lymphoma
2002 • 13 citations