The Effect of Orlistat, an Inhibitor of Dietary Fat Absorption, on the Pharmacokinetics of β‐Carotene in Healthy Volunteers

The Two-Period Change-Over Design and Its Use in Clinical Trials

1965 • 786 citations

Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin

1988 • 338 citations

Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers

1994 • 278 citations

Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene

1989 • 273 citations

Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin

1988 • 254 citations

Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study.

1995 • 212 citations

Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18–0647 (tetrahydrolipstatin)

1992 • 180 citations

Review of Limited Systemic Absorption of Orlistat, a Lipase Inhibitor, in Healthy Human Volunteers

1995 • 167 citations

Lipase inhibition: a novel concept in the treatment of obesity.

1993 • 151 citations

Distribution of orally administered β-carotene among lipoproteins in healthy men

1992 • 139 citations

Intra- and interindividual variation in measurements of beta-carotene, retinol, and tocopherols in diet and plasma

1987 • 118 citations

The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia

1994 • 95 citations

Determinants of increase in plasma concentration of β-carotene after chronic oral supplementation

1991 • 88 citations

Serum level changes after administration of a pharmacologic dose of beta-carotene

1988 • 75 citations

Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat

1989 • 63 citations

Corrections: The Two-Period Change-Over Design and Its Use in Clinical Trials

1974 • 34 citations

Pharmacokinetics of endogenous substances: Some problems and some solutions

1993 • 31 citations