TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

1998 • 9,382 citations

UPDATE ON DRUG RESISTANCE MUTATIONS IN HIV-1

2001 • 1,694 citations

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1988 • 1,634 citations

The search for synergy: a critical review from a response surface perspective.

1995 • 1,351 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes

1993 • 788 citations

Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naïve patients

2000 • 553 citations

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

1998 • 395 citations

Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults

2001 • 382 citations

Novel bis -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

2003 • 370 citations

Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

2004 • 230 citations

High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains

2004 • 217 citations

Dual-attribute continuous monitoring of cell proliferation/cytotoxicity.

1993 • 206 citations

3-Year Suppression of HIV Viremia with Indinavir, Zidovudine, and Lamivudine

2000 • 205 citations

Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing

1993 • 200 citations

BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

2000 • 195 citations

Travel and the spread of HIV-1 genetic variants

2003 • 194 citations

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

1991 • 186 citations

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

1998 • 151 citations

A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site

2002 • 137 citations

Update of the drug resistance mutations in HIV-1: 2004.

2004 • 81 citations

Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease

1996 • 79 citations

Increasing Prevalence of Non–Clade B HIV-1 Strains in Heterosexual Men and Women, as Monitored by Analysis of Reverse Transcriptase and Protease Sequences

2001 • 73 citations

Human immunodeficiency virus type-1 protease inhibitors therapeutic successes and failures, suppression and resistance

2000 • 68 citations

Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro

1997 • 59 citations

Evaluation of an early intervention Tier 2 child and adolescent mental health service

2004 • 58 citations

In Vitro Antiviral Interaction of Lopinavir with Other Protease Inhibitors

2002 • 54 citations

Antagonism between Human Immunodeficiency Virus Type 1 Protease Inhibitors Indinavir and Saquinavir In Vitro

1997 • 32 citations

Culture of HIV in Monocytes and Macrophages

2004 • 13 citations