Antiinflammatory drugs and gastric mucosal damage

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Cytoprotection by prostaglandins in rats

1979 • 1,698 citations

Cytoprotection by prostaglandins

1979 • 1,076 citations

Physiology of the Gastrointestinal Tract

1981 • 859 citations

Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms

1983 • 604 citations

Association of Adrenocorticosteroid Therapy and Peptic-Ulcer Disease

1983 • 429 citations

Prostaglandins and the gastrointestinal mucosa: Are they important in its function, disease, or treatment?

1985 • 378 citations

Nonassociation of Adrenocorticosteroid Therapy and Peptic Ulcer

1976 • 357 citations

Salicylate Damage to the Gastric Mucosal Barrier

1967 • 347 citations

Occult blood screening for colorectal carcinoma: A critical review

1985 • 338 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

Gastroscopic evaluation of anti-inflammatory agents

1980 • 324 citations

Incidence of Gastric Lesions in Patients with Rheumatic Disease on Chronic Aspirin Therapy

1979 • 322 citations

Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract

1985 • 310 citations

Aspirin Use in Patients with Major Upper Gastrointestinal Bleeding and Peptic-Ulcer Disease

1974 • 304 citations

Role of Surface-Active Phospholipids in Gastric Cytoprotection

1983 • 296 citations

Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine.

1979 • 279 citations

MECHANISMS UNDERLYING GASTRIC MUCOSAL DAMAGE INDUCED BY INDOMETHACIN AND BILE‐SALTS, AND THE ACTIONS OF PROSTAGLANDINS

1977 • 272 citations

Endoscopic Evaluation of the Effects of Aspirin, Buffered Aspirin, and Enteric-Coated Aspirin on Gastric and Duodenal Mucosa

1980 • 266 citations

Endoscopic Studies of Gastric and Duodenal Injury after the Use of Ibuprofen, Aspirin, and Other Nonsteroidal Anti-Inflammatory Agents

1984 • 261 citations

Gastric gel mucus thickness: Effect of distention, 16,16-dimethyl prostaglandin E2, and carbenoxolone

1981 • 240 citations

Aspirin and the Stomach

1986 • 238 citations

MICROGNATHIA

1947 • 224 citations

THE TWO-COMPONENT MUCOUS BARRIER

1954 • 222 citations

The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats

1979 • 221 citations

Role of prostaglandins in the formation of aspirin-induced gastric ulcers

1981 • 218 citations

Advances in Inflammation Research

1983 • 211 citations

Gastric adaptation occurs with aspirin administration in man

1983 • 207 citations

Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion.

1983 • 205 citations

Utilization of nonsteroidal antiinflammatory drugs

1985 • 190 citations

Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion

1983 • 187 citations

The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers

1979 • 167 citations

Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates

1978 • 154 citations

Retardation of acid diffusion by pig gastric mucosa: a potential role in mucosal protection.

1980 • 148 citations

Precipitins to Dietary Proteins in Serum and Upper Intestinal Secretions of Coeliac Children

1972 • 146 citations

Mucosubstance as a Barrier to Diffusion

1959 • 142 citations

Aspirin-Induced Ultrastructural Changes in Human Gastric Mucosa

1976 • 140 citations

Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.

1967 • 138 citations

Retardation of acid diffusion by pig gastric mucus: A potential role in mucosal protection

1980 • 135 citations

Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases

1980 • 134 citations

From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs

1983 • 127 citations

Demonstration of a pH gradient across the mucus layer on the surface of human gastric mucosa in vitro.

1982 • 123 citations

Effect of indomethacin and aspirin on gastric blood flow and acid secretion.

1977 • 122 citations

A comparative endoscopic evaluation of the damaging effects of nonsteroidal anti-inflammatory agents on the gastric and duodenal mucosa.

1981 • 116 citations

Stimulation by intragastrically administered E₂prostaglandins of human gastric mucus output

1979 • 114 citations

The biosynthesis of intestinal mucins. The effect of salicylate on glycoprotein biosynthesis by sheep colonic and human gastric mucosal tissues in vitro

1968 • 108 citations

Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa

1979 • 107 citations

Salicylates and Gastro-intestinal Bleeding

1962 • 107 citations

Effect of aspirin on the human stomach in normals: endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration.

1981 • 106 citations

Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2.

1983 • 103 citations

The effects of aspirin and other non-steroid anti-inflammatory/analgesic drugs on gastro-intestinal mucus glycoprotein biosynthesis in vivo: Relationship to ulcerogenic actions

1978 • 103 citations

Upper gastrointestinal endoscopy in normal asymptomatic volunteers

1986 • 102 citations

An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species

1982 • 102 citations

Influence of Long-Term 16,16-Dimethyl Prostaglandin E2 Treatment on the Rat Gastrointestinal Mucosa

1983 • 101 citations

A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects

1986 • 101 citations

Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma

1982 • 100 citations

Effect of indomethacin on basal and histamine stimulated human gastric acid secretion.

1984 • 99 citations

Mucosal Microvascular Architecture of the Fundus and Body of Human Stomach

1984 • 99 citations

An endoscopic evaluation of the effects of non-steroidal anti-inflammatory drugs on the gastric mucosa

1975 • 98 citations

Alcohol, Aspirin, and Gastrointestinal Bleeding

1968 • 96 citations

Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: An endoscopic study

1984 • 96 citations

Effect of Chronic Aspirin Ingestion on Epithelial Proliferation in Rat Fundus, Antrum, and Duodenum

1982 • 94 citations

Peptic Ulceration Occurring During Therapy for Rheumatoid Arthritis

1957 • 92 citations

Indomethacin: A survey of clinical trials

1968 • 91 citations

EFFECT OF 15(R)15 METHYLPROSTAGLANDIN E2 METHYL ESTER ON HEALING OF GASTRIC ULCERS

1974 • 89 citations

Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion

1983 • 88 citations

STUDIES OF GASTROINTESTINAL BLEEDING CAUSED BY CORTICOSTEROIDS, SALICYLATES, AND OTHER ANALGESICS<sup>1</sup>

1961 • 88 citations

EFFECTS OF FASTING, STRESS AND DRUGS ON GASTRIC GLYCOPROTEIN SYNTHESIS IN THE RAT

1975 • 87 citations

Protective Effect of Cimetidine on Aspirin-Induced Gastric Mucosal Damage

1977 • 84 citations

Effect of 16,16 dimethyl prostaglandin E2 on aspirin induced damage to rat gastric epithelial cells in tissue culture.

1984 • 84 citations

Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues.

1977 • 83 citations

Effect of Several Drugs on Gastric Potential Difference in Man

1974 • 81 citations

Protection Against Aspirin-Induced Antral and Duodenal Damage with Enprostil

1985 • 81 citations

Aspirin and gastric ulcer.

1975 • 78 citations

DRUG-INDUCED GASTROINTESTINAL BLEEDING

1978 • 76 citations

Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers

1977 • 74 citations

Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.

1983 • 73 citations

Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin

1982 • 72 citations

A functional model for extracellular gastric mucus in the rat

1984 • 71 citations

Indomethacin in Rheumatic Diseases: A Controlled Clinical Trial

1964 • 71 citations

Correlation of Mucosal Histology and Aspirin Intake in Chronic Gastric Ulcer

1973 • 69 citations

Influence of Adrenocorticotropin, Cortisone, Aspirin, and Phenylbutazone on the Rate of Exfoliation and the Rate of Renewal of Gastric Mucosal Cells

1970 • 68 citations

Prevention of aspirin-induced faecal blood loss by prostaglandin E2.

1980 • 66 citations

Albumin metabolism in rheumatoid arthritis.

1971 • 63 citations

Achalasia and Hodgkinʼs Disease

1981 • 62 citations

Cimetidine for peptic ulcer in patients with arthritis.

1980 • 60 citations

A Controlled Endoscopic Study Comparing the Toxic Effects of Sulindac, Naproxen, Aspirin, and Placebo on the Gastric Mucosa of Healthy Volunteers

1984 • 57 citations

Effect of Prednisolone on Gastric Mucus Content and on Ulcer Formation

1963 • 57 citations

Gastroduodenal Damage due to Drugs, Alcohol and Smoking

1984 • 56 citations

Electrolyte diffusion in relation to the acidity regulation of the gastric juice.

1968 • 55 citations

Comparison of gastrointestinal effects of aspirin and fenoprofen

1979 • 53 citations

Measurement of Side Effects of Drugs

1974 • 53 citations

Salicylate-induced gastrointestinal bleeding: comparison between soluble buffered, enteric-coated, and intravenous administration.

1979 • 50 citations

Gastrointestinal blood loss from aspirin and sodium salicylate tablets in man

1973 • 46 citations

Ibuprofen or Aspirin in Rheumatoid Arthritis Therapy

1975 • 46 citations

Cimetidine in the treatment of gastric ulcer induced by steroidal and nonsteroidal anti-inflammatory agents.

1981 • 46 citations

Progress report. Aspirin in chronic gastric ulcer: an Australian experience.

1976 • 46 citations

Reduction of Aspirin-Induced Gastroduodenal Mucosal Damage with Ranitidine

1986 • 44 citations

Healing of Peptic Ulcers During Continuing Anti-inflammatory Drug Therapy in Rheumatoid Arthritis

1981 • 43 citations

Effect of prostaglandin E2 on gastric mucosal bleeding caused by aspirin

1981 • 43 citations

Gastric ulcer and the anti-arthritic drugs

1971 • 42 citations

Effects of non-steroidal anti-inflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro

1983 • 42 citations

A role for milk phospholipids in protection against gastric acid

1984 • 40 citations

Gastric vascular actions of prostanoids and the dual effect of arachidonic acid

1982 • 39 citations

Prostaglandin E2 prevents aspirin and indomethacin damage to human gastric mucosa.

1976 • 36 citations

Gastrointestinal blood loss caused by tolmetin, aspirin, and indomethacin

1974 • 34 citations

Gastric Bicarbonate Secretion in Humans

1983 • 34 citations

Gastrointestinal blood loss after diflunisal and after aspirin: Effect of ethanol

1978 • 34 citations

Effect of paracetamol on gastric mucosa.

1978 • 33 citations

Acute toxicity of aspirin in hospitalized medical patients

1977 • 32 citations

Chronic Gastric Ulcer Induced by Aspirin: An Experimental Model

1973 • 30 citations

Chronic gastric ulcer induced by aspirin: an experimental model.

1973 • 30 citations

Peptic ulcer in rheumatoid arthritis and relationship to steroid treatment

1960 • 29 citations

Effects of Methylprednisolone on Hydrogen Ion Absorption in the Canine Stomach

1978 • 28 citations

Effects of fenoprofen and aspirin on gastrointestinal microbleeding in man

1973 • 28 citations

Gastrointestinal microbleeding after aspirin and naproxen

1978 • 27 citations

Intestinal blood loss after a new anti‐inflammatory drug, sulindac

1976 • 26 citations

A six-month double-blind trial of ibuprofen and indomethacin in osteoarthritis.

1975 • 24 citations

Piroxicam, aspirin, and gastrointestinal blood loss

1982 • 23 citations

Prevention of aspirin-induced fecal blood loss with oral prostaglandin E2: Dose-response studies in man

1981 • 23 citations

Comparison of Serum Salicylate Levels and Gastro-Intestinal Blood Loss Between Salsalate (Disalcid) and other Forms of Salicylates

1981 • 23 citations

A six-month double-blind trial of ibuprofen and indomethacin in osteoarthritis.

1975 • 22 citations

Effect of intravenous and intrajejunal fat infusion on gastric acid secretion and plasma neurotensin-like immunoreactivity in man.

1984 • 21 citations

Suppression of Thymidine Incorporation into the Gastric Mucosa of Cortisone-Treated Rats: Possible Relation to Glucocorticoid-Induced Gastric Ulceration

1973 • 20 citations

Antiinflammatory Drugs and Gastrointestinal Bleeding: A Comparison of Aspirin and Ibuprofen

1976 • 18 citations

Comparison of benefit-to-risk ratios of aspirin and fenoprofen: controlled multicentre study in rheumatoid arthritis.

1976 • 17 citations

A therapeutic trial of 15(R)-15-methyl prostaglandin E2 in rheumatoid arthritis patients with gastroduodenal lesions

1981 • 17 citations

CHOLINE MAGNESIUM TRISALICYLATE VERSUS IBUPROFEN IN RHEUMATOID ARTHRITIS

1980 • 16 citations

A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen.

1977 • 15 citations

Drug-induced peptic ulcer and upper gastrointestinal bleeding.

1980 • 15 citations

ENDOSCOPIC EVALUATION OF THE COMPARATIVE EFFECTS OF ACETYLSALICYCLIC ACID AND CHOLINE MAGNESIUM TRISALICYLATE ON HUMAN GASTRIC AND DUODENAL MUCOSA

1983 • 14 citations

Four Years of Clinical Experience with Naproxen–And Objective Methods of Evaluation

1973 • 12 citations

Serum immunoreactive gastrin in rheumatoid arthritis. Further observations on its identity, clinical specificity, and relationship to gastric function.

1976 • 12 citations

Diflunisal in general practice

1978 • 12 citations

Drug-induced Bleeding

1974 • 12 citations

Fenoprofen in rheumatoid arthritis: a controlled crossover multi-centre study.

1976 • 11 citations

Studies of the pH gradient across gastric mucus.

1984 • 10 citations

Sucralfate in the Relief of Gastrointestinal Symptoms Associated With Nonsteroidal Anti-inflammatory Drugs

1985 • 10 citations

Nonsteroidal anti-inflammatory drug gastropathy. We started it--can we stop it?

1986 • 9 citations

Clinical Gastroenterology

1977 • 8 citations

Glucocorticoid and mineralocorticoid actions on gastric secretion in man.

1977 • 7 citations

Are prostaglandins truly "cytoprotective"?

1986 • 6 citations

Are Prostaglandins Truly “Cytoprotective”?

1986 • 6 citations

Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis.

1977 • 6 citations

Ibuprofen or aspirin in rheumatoid arthritis therapy

1975 • 5 citations

Enzymes in intestinal mucosa from patients with rheumatoid diseases.

1976 • 4 citations

The basic facts

1985 • 4 citations

Double-blind placebo controlled cross-over study on cimetidine--prophylactic effect in patients under steroid treatment. Preliminary data.

1980 • 3 citations