Therapeutic effects of organic Germanium

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

THE EFFECT OF COLCHICINE ON ROOT MITOSES IN ALLIUM

2010 • 564 citations

The AIDS Virus

1987 • 204 citations

The First Human Retrovirus

1986 • 168 citations

Induction of Interferon and Activation of NK Cells and Macrophages in Mice by Oral Administration of Ge‐132, an Organic Germanium Compound

1985 • 99 citations

Accumulation of germanium in the tissues of a long-term user of germanium preparation died of acute renal failure.

1985 • 75 citations

Antiarthritic and immunoregulatory activity of spirogermanium.

1986 • 50 citations

Abnormal trace metals in man: Germanium

1967 • 48 citations

Spirans XXII. Synthesis of 4,4‐dialkyl‐4‐germacyclohexanone and 8,8‐dialkyl‐8‐germaazaspiro [4.5] decanes

1974 • 44 citations

Cytotoxic effects and biological activity of 2-aza-8-germanspiro[4,5]-decane-2-propanamine-8,8-diethyl-N,N-dimethyl dichloride (NSC 192965; spirogermanium) in vitro.

1982 • 41 citations

Antitumor effect of the organogermanium compound Ge-132 on the Lewis lung carcinoma (3LL) in C57Bl/6 (B6) mice.

1985 • 39 citations

Cooperation of lymphokine(s) and macrophages in expression of antitumor activity of carboxyethylgermanium sesquioxide (Ge-132).

1986 • 38 citations

Phase I clinical trial of spirogermanium.

1980 • 37 citations

Generation of suppressor cells in normal rats by treatment with spirogermanium, a novel heterocyclic anticancer drug

1985 • 28 citations

Importance of T-cells and macrophages in the antitumor activity of carboxyethylgermanium sesquioxide (Ge-132).

1985 • 27 citations

Phase II trial of spirogermanium for treatment of advanced breast cancer.

1983 • 24 citations

Restoration of Impaired Immunoresponse by Germanium in Mice

1980 • 22 citations

Phase II study of spirogermanium in advanced ovarian malignancy.

1981 • 21 citations

Determination of germanium in medicinal plants by atomic absorption spectrometry with electrothermal atomization.

1980 • 18 citations

Prevention of Suppressed Interferon Gamma Production in Thermally Injured Mice by Administration of a Novel Organogermanium Compound, Ge-132

1984 • 17 citations

Analgesic effect of novel organogermanium compound, Ge-132.

1983 • 16 citations

A phase II study of spirogermanium in advanced human malignancy

1985 • 16 citations

Identification of synergistic combinations of spirogermanium with 5-fluorouracil or cisplatin using a range of human tumour cell lines in vitro

1984 • 16 citations

Inhibition of tumor growth and metastasis in association with modification of immune response by novel organic germanium compounds.

1985 • 11 citations

Effect of spirogermanium on V79 Chinese hamster cells

1983 • 11 citations

A Phase I trial of spirogermanium administered on a continuous infusion schedule

1984 • 11 citations

Spirogermanium: a new drug with antimalarial activity against chloroquine-resistant Plasmodium falciparum.

1983 • 10 citations

[Antitumor activity of Ge-132, a new organogermanium compound, in mice is expressed through the functions of macrophages and T lymphocytes].

1985 • 10 citations

A phase II study of spirogermanium in patients with metastatic malignant melanoma

1985 • 9 citations

Phase II study of spirogermanium in advanced breast cancer.

1984 • 9 citations

Phase II study of spirogermanium in advanced (extensive) non-small cell lung cancer.

1986 • 8 citations

A phase II study of spirogermanium as second line therapy in patients with poor prognosis lymphoma

1985 • 8 citations

Phase II study of spirogermanium in patients with advanced carcinoma of the cervix.

1985 • 7 citations

Phase II trial of spirogermanium in advanced renal cell carcinoma: a Cancer and Leukemia Group B study.

1984 • 7 citations

[Suppression of tumor growth by peritoneal macrophages isolated from mice treated with carboxyethylgermanium sesquioxide (Ge-132)].

1985 • 7 citations

Phase II evaluation of spirogermanium in advanced ovarian carcinoma.

1983 • 6 citations

[Augmentation of NK activity in peripheral blood lymphocytes of cancer patients by intermittent GE-132 administration].

1984 • 6 citations

Phase II study of spirogermanium in metastatic prostate cancer.

1986 • 6 citations

Inhibitory effects of Ge-132 (carboxyethyl germanium sesquioxide) derivatives on enkephalin-degrading enzymes.

1986 • 6 citations

[Effect of combination immunochemotherapy with an organogermanium compound, Ge-132, and antitumor agents on C57BL/6 mice bearing Lewis lung carcinoma (3LL)].

1986 • 5 citations

Continuous-infusion spirogermanium for the treatment of refractory carcinoma of the ovary: a phase II trial.

1985 • 5 citations

Central action of sanumgerman in mice.

1986 • 2 citations

Phase II Eastern Cooperative Oncology Group Study of spirogermanium in previously treated lymphoma.

1986 • 2 citations

[Synthesis of anomeric 5-trimethylgermyl-2'-deoxyuridines and study of their antiviral and cytotoxic properties].

1985 • 2 citations

[Ability of sera from mice treated with Ge-132, an organo-germanium compound, to inhibit experimental murine ascites tumors].

1985 • 1 citations