Patterning the earlyXenopusembryo

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

2001 • 807 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

2000 • 677 citations

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS

2004 • 652 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

2003 • 580 citations

Vital dye mapping of the gastrula and neurula of Xenopus laevis

1976 • 576 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach

2000 • 523 citations

β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

1996 • 516 citations

Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos

2005 • 503 citations

Fate map for the 32-cell stage ofXenopus laevis

1987 • 500 citations

The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos

1998 • 477 citations

Molecular Genetics of Axis Formation in Zebrafish

2005 • 473 citations

Vital dye mapping of the gastrula and neurula of Xenopus laevis

1975 • 437 citations

Endodermal Nodal-related signals and mesoderm induction in Xenopus

2000 • 415 citations

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

1997 • 404 citations

Links between Tumor Suppressors

2003 • 372 citations

Germ-Layer Specification and Control of Cell Growth by Ectodermin, a Smad4 Ubiquitin Ligase

2005 • 338 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

1997 • 311 citations

Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning

1996 • 309 citations

Xwnt-11: a maternally expressed Xenopus wnt gene

1993 • 308 citations

Neural induction inXenopusrequires early FGF signalling in addition to BMP inhibition

2004 • 282 citations

Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm

1996 • 280 citations

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

1996 • 275 citations

Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors

1999 • 265 citations

β-catenin, MAPK and Smad signaling during earlyXenopusdevelopment

2002 • 265 citations

FGF-8Is Associated with Anteroposterior Patterning and Limb Regeneration inXenopus

1997 • 258 citations

Endogenous patterns of TGFβ superfamily signaling during early Xenopus development

2000 • 256 citations

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

1999 • 255 citations

Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps.

1996 • 248 citations

Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field

2005 • 247 citations

Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation

1996 • 241 citations

Serotonin Signaling Is a Very Early Step in Patterning of the Left-Right Axis in Chick and Frog Embryos

2005 • 241 citations

A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule

1998 • 239 citations

Kaiso/p120-Catenin and TCF/β-Catenin Complexes Coordinately Regulate Canonical Wnt Gene Targets

2005 • 227 citations

Depletion of Three BMP Antagonists from Spemann's Organizer Leads to a Catastrophic Loss of Dorsal Structures

2005 • 226 citations

Determination of the dorsal-ventral axis in eggs of Xenopus laevis: Complete rescue of uv-impaired eggs by oblique orientation before first cleavage

1980 • 226 citations

Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis

2001 • 223 citations

Embryonic Dorsal-Ventral Signaling: Secreted Frizzled-Related Proteins as Inhibitors of Tolloid Proteinases

2006 • 221 citations

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

2005 • 213 citations

β-Catenin/Tcf-regulated transcription prior to the midblastula transition

2002 • 212 citations

Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm

2000 • 204 citations

The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation

1996 • 203 citations

TGF-β signals and a prepattern in Xenopus laevis endodermal development

1996 • 196 citations

Maternal β-catenin establishes a ‘dorsal signal’ in early Xenopus embryos

1996 • 191 citations

Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3

1998 • 190 citations

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD

2004 • 190 citations

Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and Cerberus

2004 • 179 citations

Role of glypican 4 in the regulation of convergent extension movements during gastrulation inXenopus laevis

2003 • 179 citations

derrière: a TGF-β family member required for posterior development in Xenopus

1999 • 178 citations

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin

2004 • 169 citations

Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos

1997 • 162 citations

Subcortical rotation in Xenopus eggs: An early step in embryonic axis specification

1987 • 162 citations

Antero-posterior tissue polarity links mesoderm convergent extension to axial patterning

2004 • 156 citations

FGF Signal Interpretation Is Directed by Sprouty and Spred Proteins during Mesoderm Formation

2005 • 146 citations

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation inXenopusembryos

2005 • 146 citations

The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning

2000 • 142 citations

Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation

2005 • 141 citations

Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex ofXenopusoocytes

2005 • 140 citations

Autonomous Endodermal Determination in Xenopus: Regulation of Expression of the Pancreatic Gene XlHbox 8

1995 • 134 citations

The roles of three signaling pathways in the formation and function of the Spemann Organizer

2002 • 133 citations

Vegetal rotation, a new gastrulation movement involved in the internalization of the mesoderm and endoderm in Xenopus

1999 • 132 citations

Delocalization of Vg1 mRNA from the Vegetal Cortex in Xenopus Oocytes After Destruction of Xlsirt RNA

1994 • 131 citations

Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development

1999 • 130 citations

Fates and states of determination of single vegetal pole blastomeres of X. laevis

1984 • 130 citations

Localized synthesis of the Vg1 protein during early Xenopus development

1989 • 129 citations

Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis

2004 • 125 citations

Lefty-Dependent Inhibition of Nodal- and Wnt-Responsive Organizer Gene Expression Is Essential for Normal Gastrulation

2002 • 121 citations

Guidance of mesoderm cell migration in theXenopusgastrula requires PDGF signaling

2004 • 118 citations

Vg1 is an essential signaling molecule inXenopusdevelopment

2005 • 118 citations

Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation

2004 • 116 citations

Kaiso is a genome-wide repressor of transcription that is essential for amphibian development

2004 • 115 citations

The β-catenin/VegT-regulated early zygotic geneXnr5is a direct target of SOX3 regulation

2003 • 113 citations

I‐SceI meganuclease‐mediated transgenesis in Xenopus

2005 • 112 citations

Timing of endogenous activin-like signals and regional specification of theXenopusembryo

2001 • 112 citations

Mesoderm-inducing factors and the control of gastrulation

1992 • 111 citations

Repression of organizer genes in dorsal and ventralXenopuscells mediated by maternal XTcf3

2002 • 107 citations

Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction

2004 • 103 citations

Goosecoid and Mix.1 repress Brachyury expression and are required for head formation in Xenopus

1999 • 102 citations

Specialized and redundant roles of TBP and a vertebrate-specific TBP paralog in embryonic gene regulation in Xenopus

2004 • 97 citations

Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation

2004 • 97 citations

Conserved Requirement of Lim1 Function for Cell Movements during Gastrulation

2003 • 97 citations

Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects

2005 • 94 citations

A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor

2003 • 92 citations

Vegetal Localization of Maternal mRNAs Is Disrupted by VegT Depletion

2001 • 91 citations

Intrinsic Differences between the Superficial and Deep Layers of the Xenopus Ectoderm Control Primary Neuronal Differentiation

2002 • 91 citations

Region-specific activation of the Xenopus Brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos

2000 • 90 citations

GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression inXenopusembryos

2005 • 87 citations

The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC

2004 • 87 citations

Zygotic Wnt Activity Is Required for Brachyury Expression in the Early Xenopus laevis Embryo

2002 • 83 citations

Differential expression of VegT and Antipodean protein isoforms in Xenopus

1999 • 81 citations

Endoderm Specification and Differentiation in Xenopus Embryos

2001 • 79 citations

Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann’s organizer

2001 • 77 citations

Spatially Regulated Translation in Embryos: Asymmetric Expression of Maternal Wnt-11 along the Dorsal–Ventral Axis in Xenopus

1999 • 76 citations

Sending RNAs into the Future: RNA Localization and Germ Cell Fate

2004 • 76 citations

The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation

2000 • 76 citations

Visualizing Long-Range Movement of the Morphogen Xnr2 in the Xenopus Embryo

2004 • 71 citations

eFGF is required for activation ofXmyoDexpression in the myogenic cell lineage ofXenopus laevis

2002 • 69 citations

New roles for FoxH1 in patterning the early embryo

2004 • 68 citations

GBP binds kinesin light chain and translocates during cortical rotation inXenopuseggs

2003 • 67 citations

Designation of the Anterior/Posterior Axis in Pregastrula Xenopus laevis

2000 • 66 citations

Morphogenesis duringXenopusgastrulation requires Wee1-mediated inhibition of cell proliferation

2004 • 65 citations

Xbrafunctions as a switch between cell migration and convergent extension in theXenopusgastrula

2003 • 63 citations

Axis and germ line deficiencies caused by u.v. irradiation of Xenopus oocytes cultured in vitro

1987 • 62 citations

Cell Lineage Analysis in Xenopus Embryos

2003 • 61 citations

The Role of Maternal Axin in Patterning the Xenopus Embryo

2001 • 58 citations

Rearrangement of chromatin domains during development inXenopus

2000 • 57 citations

BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation

2005 • 57 citations

Activin redux: specification of mesodermal pattern inXenopusby graded concentrations of endogenous activin B

2004 • 57 citations

The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4

2003 • 56 citations

Xenopus Xpat protein is a major component of germ plasm and may function in its organisation and positioning

2005 • 54 citations

Xema, afoxi-class gene expressed in the gastrula stageXenopusectoderm, is required for the suppression of mesendoderm

2005 • 54 citations

Identification of mutants in inbred Xenopus tropicalis

2005 • 52 citations

XSIP1 is essential for early neural gene expression and neural differentiation by suppression of BMP signaling

2004 • 52 citations

Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes

2005 • 51 citations

Molecular link in the sequential induction of the Spemann organizer: direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and Siamois, immediately downstream from Nodal and Wnt signaling

2003 • 50 citations

Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1

2002 • 48 citations

Xenopus XsalF

2004 • 42 citations

The role ofMixerin patterning the earlyXenopusembryo

2004 • 42 citations

MaternalXenopus Zic2negatively regulatesNodal-relatedgene expression during anteroposterior patterning

2005 • 41 citations

Direct and indirect regulation ofderrière, aXenopusmesoderm-inducing factor, by VegT

2002 • 39 citations

VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula

2003 • 38 citations

Temporal analysis of the early BMP functions identifies distinct anti-organizer and mesoderm patterning phases

2005 • 34 citations

XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos

2005 • 32 citations

Xotx1 maternal transcripts are vegetally localized in Xenopus laevis oocytes

2000 • 32 citations

Subdividing the embryo: A role for Notch signaling during germ layer patterning in Xenopus laevis

2005 • 30 citations

Epigenetic silencing in embryogenesis

2005 • 30 citations

Regulation of Src kinase activity during Xenopus oocyte maturation

2004 • 28 citations

Neural induction and patterning in embryos deficient in FGF signaling.

1997 • 27 citations

A cell cycle arrest is necessary for bottle cell formation in the early Xenopus gastrula: Integrating cell shape change, local mitotic control and mesodermal patterning

2005 • 24 citations

Inhibition of FGF signaling causes expansion of the endoderm in Xenopus

2004 • 22 citations

The role of maternal CREB in early embryogenesis of Xenopus laevis

2003 • 19 citations

When does the anterior endomesderm meet the anterior-most neuroectoderm during Xenopus gastrulation?

2002 • 9 citations

eFGF is required for activation of XmyoD expression in the myogenic cell lineage of Xenopus laevis

2002 • 5 citations