Plasma and cerebrospinal fluid α1‐antichymotrypsin levels in Alzheimer's disease: Correlation with cognitive impairment

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

A New Clinical Scale for the Staging of Dementia

1982 • 6,699 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?

2000 • 384 citations

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

1995 • 337 citations

Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain

1999 • 325 citations

Research evaluation and diagnosis of possible Alzheimer’s disease over the last two decades: II

2000 • 185 citations

Longitudinal Study of Inflammatory Factors in Serum, Cerebrospinal Fluid, and Brain Tissue in Alzheimer Disease

1998 • 181 citations

α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsin

1990 • 153 citations

α1‐Antichymotrypsin as a possible biochemical marker for Alzheimer‐type dementia

1990 • 147 citations

Research evaluation and diagnosis of probable Alzheimer’s disease over the last two decades: I

2000 • 145 citations

α₁‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

1993 • 143 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

Blood Levels of Alpha-1-Antichymotrypsin and Risk Factors for Alzheimer’s Disease: Effects of Gender and Apolipoprotein E Genotype

2000 • 141 citations

α-1-Antichymotrypsin Promotes β-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer's Disease

2001 • 141 citations

Astroglial Expression of Human α1-Antichymotrypsin Enhances Alzheimer-like Pathology in Amyloid Protein Precursor Transgenic Mice

2000 • 140 citations

α1-Antichymotrypsin and IL-1β are not increased in CSF or serum in Alzheimer's disease

1994 • 96 citations

No Genetic Effect of α1-Antichymotrypsin in Alzheimer Disease

1996 • 87 citations

Acute Phase Reactant α1Antichymotrypsin Is Increased in Cerebrospinal Fluid and Serum of Patients with Probable Alzheimer Disease

1995 • 86 citations

Inflammation and Alzheimer disease

1996 • 78 citations

Increased levels of α-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype

1998 • 69 citations

Serum α1-antichymotrypsin level as a marker for Alzheimer-type dementia

1995 • 66 citations

Alpha 1-antichymotrypsin is present in diffuse senile plaques. A comparative study of beta-protein and alpha 1-antichymotrypsin immunostaining in the Alzheimer brain.

1991 • 65 citations

Expression of differential immune factors in temporal cortex and cerebellum: The role of ?-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease

1998 • 64 citations

Polymorphism in AACT gene may lower age of onset of Alzheimerʼs disease

1996 • 53 citations

α₁‐Antichymotrypsin as a risk modifier for late‐onset Alzheimer's disease in Japanese apolipoprotein E ε4 allele carriers

1997 • 46 citations

Developmental expression of α1-antichymotrypsin in brain may be related to astrogliosis

1991 • 46 citations

No association between the alpha 1‐antichymotrypsin A allele and Alzheimer's disease

1997 • 38 citations

Serological α₁‐Antichymotrypsin in Down's syndrome and Alzheimer's disease

1992 • 37 citations

Relationship between serum α1-antichymotrypsin and Alzheimer's disease

1994 • 37 citations

Apolipoprotein E and α₁‐antichymotrypsin polymorphism in Alzheimer's disease

1996 • 36 citations

Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome

1995 • 34 citations

The Protease Inhibitor, α1-Antichymotrypsin, Is a Component of the Brain Amyloid Deposits in Normal Aging and Alzheimer's Disease

1989 • 34 citations

?1-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease

1996 • 33 citations

Immunohistochemical demonstration of proteinase inhibitor alpha‐1‐antichymotrypsin in normal human central nervous system

1987 • 30 citations

Effect of cytokines, dexamethazone and the A/T-signal peptide polymorphism on the expression of alpha1-antichymotrypsin in astrocytes: significance for Alzheimer's disease

2001 • 29 citations

α-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population

1998 • 26 citations

Serum concentration of alpha 1-antichymotrypsin is elevated in patients with senile dementia of the Alzheimer type.

1989 • 25 citations

Genetic association of two chromosome 14 genes (presenilin 1 and α₁‐Antichymotrypsin) with Alzheimer's disease

1998 • 23 citations

No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease

1997 • 20 citations

Association of Elevated α₁-Antichymotrypsin With Cognitive Impairment in a Prospective Study of the Very Old

1998 • 18 citations

Distribution of plasma α1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls

2002 • 17 citations

Aging and Alzheimer's disease: Protease inhibitors in cerebrospinal fluid

1991 • 17 citations

Acute phase reactants in Alzheimer's disease

1996 • 17 citations

Differential expression of α 1-antichymotrypsin in the aged human brain

1993 • 10 citations