Decoding Photoperiodic Time and Melatonin in Mammals: What Can We Learn from the Pars Tuberalis?

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

1994 • 1,099 citations

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

1995 • 878 citations

Mammalian Photoperiodic System: Formal Properties and Neuroendocrine Mechanisms of Photoperiodic Time Measurement

2001 • 747 citations

Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock

1997 • 706 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

Melatonin receptors: Localization, molecular pharmacology and physiological significance

1994 • 615 citations

The timed infusion paradigm for melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses?

1993 • 525 citations

Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores.

1994 • 434 citations

Effect of Melatonin on the Reproductive Systems of Male and Female Syrian Hamsters: A Diurnal Rhythm in Sensitivity to Melatonin¹²

1976 • 407 citations

Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

1993 • 394 citations

Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin

2001 • 364 citations

Mammalian pineal melatonin: A clock for all seasons

1989 • 310 citations

Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain

1998 • 305 citations

Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins

1999 • 258 citations

Photoperiodically‐lnduced Cycles in the Secretion of Prolactin in Hypothalamo‐Pituitary Disconnected Rams: Evidence for Translation of the Melatonin Signal in the Pituitary Gland

1994 • 253 citations

Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters.

1996 • 209 citations

The Mel_1aMelatonin Receptor Is Coupled to Parallel Signal Transduction Pathways¹

1997 • 188 citations

Evidence That Melatonin Acts in the Premammillary Hypothalamic Area to Control Reproduction in the Ewe: Presence of Binding Sites and Stimulation of Luteinizing Hormone Secretion byin SituMicroimplant Delivery¹

1998 • 188 citations

Decoding photoperiodic time through Per1 and ICER gene amplitude

1999 • 180 citations

Melatonin Receptors on Ovine Pars Tuberalis: Characterization and Autoradiographicai Localization

1989 • 170 citations

The circadian cycle of mPER clock gene products in the suprachiasmatic nucleus of the Siberian hamster encodes both daily and seasonal time

2000 • 146 citations

Lesions of the iodomelatonin-binding sites of the mediobasal hypothalamus spare the lactotropic, but block the gonadotropic response of male Syrian hamsters to short photoperiod and to melatonin.

1995 • 144 citations

Photoperiod differentially regulates the expression of Per1 and ICER in the pars tuberalis and the suprachiasmatic nucleus of the Siberian hamster

2000 • 136 citations

Prolonged exposure to melatonin leads to time-dependent sensitization of adenylate cyclase and down-regulates melatonin receptors in pars tuberalis cells from ovine pituitary.

1993 • 132 citations

Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors

2000 • 129 citations

The ovine pars tuberalis secretes a factor(s) that regulates gene expression in both lactotropic and nonlactotropic pituitary cells.

1996 • 116 citations

Tissue-specific abolition of Per1 expression in the pars tuberalis by pinealectomy in the Syrian hamster

2001 • 106 citations

The Pars Tuberalis: The Missing Link in the Photoperiodic Regulation of Prolactin Secretion?

2000 • 92 citations

Both Pertussis Toxin‐Sensitive and Insensitive G‐Proteins Link Melatonin Receptor to Inhibition of Adenylate Cyclase in the Ovine Pars Tuberalis

1990 • 85 citations

Melatonin Regulates the Phosphorylation of CREB in Ovine Pars Tuberalis*

1994 • 83 citations

Regulation of the Mel 1a melatonin receptor mRNA and protein levels in the ovine pars tuberalis: evidence for a cyclic adenosine 3',5'-monophosphate-independent Mel 1a receptor coupling and an autoregulatory mechanism of expression.

1996 • 77 citations

Production of a prolactin releasing factor by the ovine pars tuberalis

1996 • 76 citations

Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3′,5′-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor*

1998 • 70 citations

In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production.

1995 • 48 citations

Melatonin receptors and signal transduction during development in Siberian hamsters (Phodopus sungorus)

1991 • 47 citations

Melatonin modulates diacylglycerol and arachidonic acid metabolism in the anterior pituitary of immature rats

1990 • 46 citations

Effects of placing micro-implants of melatonin in the mediobasal hypothalamus and preoptic area on the secretion of prolactin and β-endorphin in rams

1992 • 45 citations

Melatonin suppresses the induction of AP-1 transcription factor components in the pars tuberalis of the pituitary

1996 • 45 citations

Regulation of mitogen-activated protein kinase in the pars tuberalis of the ovine pituitary: interactions between melatonin, insulin-like growth factor-1, and forskolin.

1996 • 43 citations

Phosphorylation of CREB in Ovine Pars Tuberalis is Regulated both by cyclic AMP‐Dependent and cyclic AMP‐Independent Mechanisms

1996 • 42 citations

Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells.

1992 • 41 citations

The Photoperiodic Response in Syrian Hamster Depends upon a Melatonin‐Driven Circadian Rhythm of Sensitivity to Melatonin

1995 • 41 citations

Transient Removal of Dopamine Potentiates the Stimulation of Prolactin Release by TRH but Not VIP: Stimulation via Ca<sup>2 +</sup>/Protein Kinase C Pathway

1988 • 38 citations

Melatonin Inhibits the Activation of Cyclic AMP‐Dependent Protein Kinase in Cultured Pars Tuberalis Cells from Ovine Pituitary

1991 • 38 citations

Testicular Regression in Pinealectomized Syrian Hamsters following Infusions of Melatonin Delivered on Non-Circadian Schedules1

1993 • 37 citations

Interaction of Forskolin and Melatonin on Cyclic AMP Generation in Pars Tuberalis Cells of Ovine Pituitary

1991 • 28 citations

Mechanism(s) by which the Transient Removal of Dopamine Regulation Potentiates the Prolactin-Releasing Action of Thyrotropin-Releasing Hormone

1988 • 27 citations

The recovery of ovine pars tuberalis cells from melatonin-induced sensitization is a slow, protein synthesis-dependent phenomenon

1994 • 27 citations

A role for tyrosine phosphorylation in the regulation and sensitization of adenylate cyclase by melatonin

2000 • 26 citations

Ovine Arylalkylamine N-Acetyltransferase in the Pineal and Pituitary Glands: Differences in Function and Regulation*

1999 • 25 citations

The pineal gland is not essential for circadian expression of rat period homologue (rper2) mRNA in the suprachiasmatic nucleus and peripheral tissues

2000 • 19 citations

Evidence for regulation of basic fibroblast growth factor gene expression by photoperiod and melatonin in the ovine pars tuberalis

1999 • 10 citations

Different effects of melatonin pretreatment on cAMP and LH responses of the neonatal rat pituitary cells

2000 • 9 citations