Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute
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References (39)
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
1992 • 12,726 citations
APACHE II-A Severity of Disease Classification System
1986 • 12,607 citations
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
1992 • 4,689 citations
Analysis of Binary Data
2008 • 2,760 citations
A Clinically Based Classification System for Acute Pancreatitis
1993 • 2,752 citations
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.
1992 • 942 citations
CONTROLLED TRIAL OF URGENT ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AND ENDOSCOPIC SPHINCTEROTOMY VERSUS CONSERVATIVE TREATMENT FOR ACUTE PANCREATITIS DUE TO GALLSTONES
1988 • 875 citations
Early Treatment of Acute Biliary Pancreatitis by Endoscopic Papillotomy
1993 • 790 citations
APACHE-II SCORE FOR ASSESSMENT AND MONITORING OF ACUTE PANCREATITIS
1989 • 700 citations
Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome
1996 • 619 citations
Early ERCP and Papillotomy Compared with Conservative Treatment for Acute Biliary Pancreatitis
1997 • 613 citations
Early antibiotic treatment in acute necrotising pancreatitis
1995 • 498 citations
Prediction of outcome in acute pancreatitis: A comparative study of APACHE II, clinical assessment and multiple factor scoring systems
1990 • 483 citations
Controlled Clinical Trial of Selective Decontamination for the Treatment of Severe Acute Pancreatitis
1995 • 459 citations
Relationship of necrosis to organ failure in severe acute pancreatitis
1997 • 354 citations
High early mortality rate from acute pancreatitis in Scotland, 1984–1995
1999 • 285 citations
Platelet-activating factor: a phospholipid autacoid with diverse actions
1993 • 253 citations
Inflammatory mediators and cytokines--new aspects of the pathophysiology and assessment of severity of acute pancreatitis?
1993 • 244 citations
Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis
1995 • 236 citations
Interleukin 10 prevents necrosis in murine experimental acute pancreatitis
1995 • 223 citations
Fatal pancreatitis, a consequence of excessive leukocyte stimulation?
1988 • 212 citations
Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-α polyclonal antibody
1994 • 186 citations
Inflammatory mediators in acute pancreatitis
1995 • 169 citations
Prospective placebo-controlled randomized trial of lexipafant in predicted severe acute pancreatitis
1997 • 139 citations
Acute pancreatitis as a model of sepsis
1998 • 138 citations
Influence of Etiology on the Course and Outcome of Acute Pancreatitis
1996 • 136 citations
Role of platelet activating factor in pathogenesis of acute pancreatitis in rats.
1992 • 90 citations
Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model
1995 • 86 citations
Amelioration of experimental acute pancreatitis with a potent platelet-activating factor antagonist
1994 • 82 citations
Experimental acute pancreatitis induced by platelet activating factor in rabbits.
1989 • 77 citations
Prospective placebo-controlled randomized trial of lexipafant in predicted severe acute pancreatitis
1997 • 75 citations
Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation.
1993 • 50 citations
Early antibiotic treatment in acute necrotizing pancreatitis.
1996 • 44 citations
Acute Pancreatitis: Medical Management
1995 • 39 citations
Current conservative treatment of acute pancreatitis: evidence from animal and human studies.
1993 • 29 citations
Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models
1992 • 26 citations
New Perspectives on Acute Pancreatitis
1992 • 26 citations
Adrenergic and Cholinergic Regulation of Gastric Mucus Phospholipid Secretion
1992 • 15 citations
Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist.
1996 • 12 citations
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