Hypoxia Regulates Xanthine Dehydrogenase Activity at Pre- and Posttranslational Levels

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.

1987 • 350 citations

Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control.

1992 • 342 citations

Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin.

1990 • 276 citations

Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity.

1992 • 209 citations

Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation.

1994 • 145 citations

Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells.

1992 • 142 citations

Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo

1992 • 121 citations

Sequence of the Structural Gene for Xanthine Dehydrogenase (rosy Locus) in Drosophila melanogaster

1987 • 115 citations

Molecular Cloning and Characterization of the Human Xanthine Dehydrogenase Gene (XDH)

1996 • 98 citations

Mutations Affecting Expression of the rosy Locus in Drosophila melanogaster

1987 • 89 citations

Drosophila melanogaster ma-l mutants are defective in the sulfuration of desulfo Mo hydroxylases.

1982 • 88 citations

Purification and partial characterization of xanthine oxidase from human milk

1992 • 77 citations

Interferons induce xanthine dehydrogenase gene expression in L929 cells

1992 • 57 citations

Chromosomal Mapping, Isolation, and Characterization of the Mouse Xanthine Dehydrogenase Gene

1994 • 50 citations

Hyperoxia and self- or neutrophil-generated O2 metabolites inactivate xanthine oxidase

1988 • 49 citations

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

1996 • 45 citations

The contribution of vascular endothelial xanthine dehydrogenase/oxidase to oxygen-mediated cell injury

1992 • 41 citations

Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma-stimulated macrophages.

1994 • 36 citations

Determination of Xanthine Dehydrogenase mRNA by a Reverse Transcription-Coupled Competitive Quantitative Polymerase Chain Reaction Assay: Regulation in Rat Endothelial Cells by Hypoxia and Hyperoxia

1996 • 32 citations

Purification of Xanthine Oxidase from human heart

1993 • 30 citations

Inactivation of xanthine oxidase by hydrogen peroxide involves site-directed hydroxyl radical formation

1991 • 25 citations

Differential induction of fraction I and fraction II of δ-aminolevulinate synthetase in Rhodopseudomonas spheroides under various incubation conditions

1970 • 24 citations

Thyroxine increases the levels of epidermal growth factor messenger ribonucleic acid (EGF mRNA) in the thyroid in vivo, as revealed by quantitative reverse transcription polymerase chain reaction with an internal control EGF mRNA.

1993 • 23 citations