Role of the Liver in Regulating Somatomedin Activity: Hormonal Effects on the Synthesis and Release of Insulin-Like Growth Factor and Its Carrier Protein by the Isolated Perfused Rat Liver*

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS

1951 • 806 citations

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

1963 • 399 citations

A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts

1973 • 335 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Demonstration of Specific Plasma Protein Binding Sites For Somatomedin

1977 • 272 citations

The Effects of Insulin and Growth Hormone on the Release of Somatomedin by the Isolated Rat Liver

1976 • 209 citations

Regulation of Net Biosynthesis of Serum Albumin and Acute Phase Plasma Proteins

1969 • 194 citations

Multiplication‐stimulating activity for chicken embryo fibroblasts from rat liver cell conditioned medium: A family of small polypeptides

1973 • 181 citations

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

1976 • 161 citations

Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone

1976 • 146 citations

FURTHER IMMUNOLOGICAL STUDIES ON THE FORM OF CIRCULATING INSULIN

1962 • 123 citations

DNA Synthesis in Human Fibroblasts: Stimulation by Insulin and by Nonsuppressible Insulin-like Activity (NSILA-S)

1974 • 122 citations

Purified multiplication-stimulating activity from rat liver cell conditioned medium: Comparison of biological activities with calf serum, insulin, and somatomedin

1974 • 120 citations

Fibroblasts as an Experimental Tool in Metabolic and Hormone Studies

1973 • 114 citations

Nonsuppressible insulin-like activity and thyroid hormones: major pituitary-dependent sulfation factors for chick embryo cartilage.

1976 • 109 citations

Circulating NSILA-s in Man: Preliminary Studies of Stimuliin Vivoand of Binding to Plasma Components

1975 • 82 citations

Reduced Serum Somatomedin Activity in Patients with Chronic Liver Disease

1974 • 76 citations

SOME BIOLOGICAL PROPERTIES OF PURIFIED SULFATION FACTOR (SF) FROM HUMAN PLASMA

1971 • 76 citations

Influence of Actinomycin D and Puromycin on Net Synthesis of Plasma Albumin and Fibrinogen by the Isolated Perfused Rat Liver

1966 • 75 citations

Comparison of Somatomedin Activity in Perfusates of Normal and Hypophysectomized Rat Livers With and Without Added Growth Hormone

1976 • 65 citations

Specific binding of nonsuppressible insulinlike activity to chicken embryo fibroblasts and to a solubilized fibroblast receptor

1975 • 65 citations

Effects of partially purified preparations with nonsuppressible insulin-like activity (NSILA-S) on sulfate incorporation into rat and chicken cartilage

1973 • 59 citations

Effects of Hypophysectomy of Liver Donor on Net Synthesis of Specific Plasma Proteins by the Isolated Perfused Rat Liver

1974 • 50 citations

NON-SUPPRESSIBLE INSULIN-LIKE ACTIVITY AND SULPHATION ACTIVITY IN SERUM EXTRACTS OF NORMAL SUBJECTS, ACROMEGALICS AND PITUITARY DWARFS

1976 • 46 citations

Biological Properties of NSILA-S

1975 • 39 citations

Effects of Hypothyroidism, Hyperthyroidism, and Thyroxine on Net Synthesis of Plasma Proteins by the Isolated Perfused Rat Liver

1973 • 33 citations

ACTION OF RAT PROLACTIN ON PLASMA SOMATOMEDIN LEVELS IN THE RAT AND ON SOMATOMEDIN RELEASE FROM PERFUSED RAT LIVER

1977 • 33 citations

Nonsuppressible Insulin-Like Activity (NSILA).II. Regulation of Serum Concentrations by Growth Hormone and Insulin*

1978 • 31 citations

THE LIVER AS A SOURCE OF SOMATOMEDIN

1976 • 30 citations

Growth hormone and articular cartilage.

1973 • 27 citations