Insulin resistance and compensatory hyperinsulinemia: Role in hypertension, dyslipidemia, and coronary heart disease

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Blood pressure, stroke, and coronary heart disease

1990 • 4,424 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

1988 • 2,276 citations

HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study.

1977 • 1,517 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

1975 • 1,114 citations

Fructose-induced insulin resistance and hypertension in rats.

1987 • 885 citations

CORONARY-HEART-DISEASE RISK AND IMPAIRED GLUCOSE TOLERANCE The Whitehall Study

1980 • 800 citations

Risk Factors for Coronary Artery Disease in Healthy Persons with Hyperinsulinemia and Normal Glucose Tolerance

1989 • 792 citations

Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

1979 • 779 citations

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

1980 • 754 citations

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

1979 • 746 citations

Epidemiology as a Guide to Clinical Decisions

1980 • 708 citations

The triglyceride issue: A view from Framingham

1986 • 675 citations

Role of Insulin in Endogenous Hypertriglyceridemia*

1967 • 523 citations

Effects of Weight Reduction on Obesity STUDIES OF LIPID AND CARBOHYDRATE METABOLISM IN NORMAL AND HYPERLIPOPROTEINEMIC SUBJECTS

1974 • 520 citations

Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes

1970 • 500 citations

Reappraisal of the role of insulin in hypertriglyceridemia

1974 • 480 citations

Resistance to Insulin-Stimulated-Glucose Uptake in Patients with Hypertension*

1988 • 433 citations

Incidence of Type II Diabetes in Mexican Americans Predicted by Fasting Insulin and Glucose Levels, Obesity, and Body-Fat Distribution

1990 • 387 citations

Cholesterol and coronary heart disease. A new era

1986 • 376 citations

PLASMA TRIGLYCERIDE AS A RISK FACTOR FOR CORONARY HEART DISEASE

1989 • 358 citations

The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: A review of randomized controlled trials

1986 • 342 citations

SERUM-INSULIN IN ESSENTIAL HYPERTENSION AND IN PERIPHERAL VASCULAR DISEASE

1966 • 328 citations

Insulin Resistance, Glucose Intolerance and Hyperinsulinemia in Patients with Hypertension

1989 • 323 citations

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

1987 • 311 citations

Diabetes, hyperinsulinaemia, and coronary risk factors in Bangladeshis in east London.

1988 • 283 citations

Insulin and blood pressure in obesity.

1985 • 281 citations

Cholesterol and Coronary Heart Disease

1986 • 278 citations

SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES

1989 • 276 citations

Effect of fructose feeding on insulin secretion and insulin action in the rat

1980 • 256 citations

Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding

1978 • 254 citations

Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man

1981 • 249 citations

Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity

1979 • 248 citations

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule.

1987 • 246 citations

WEST INDIAN ONE-YEAR-OLDS

1967 • 242 citations

Demonstration of a Relationship Between Level of Physical Training and Insulin-stimulated Glucose Utilization in Normal Humans

1983 • 236 citations

Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 Yr

1987 • 229 citations

Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia.

1975 • 227 citations

Ambient Plasma Free Fatty Acid Concentrations in Noninsulin-Dependent Diabetes Mellitus: Evidence for Insulin Resistance*

1985 • 212 citations

Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension

1988 • 209 citations

Glucose Tolerance and Blood Pressure in Two Population Samples: Their Relation to Diabetes Mellitus and Hypertension

1978 • 203 citations

High Prevalence of NIDDM and Impaired Glucose Tolerance in Indian, Creole, and Chinese Mauritians

1990 • 200 citations

Impaired Glucose Tolerance in the U. S. Population

1989 • 182 citations

Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance

1989 • 177 citations

Risk Factors for Ischaemic Heart Disease in Men and Women: Results of the 19‐Year Follow‐up of the Stockholm Prospective Study

1985 • 177 citations

RISK FACTORS FOR ISCHqMIC HEART-DISEASE IN NORMAL MEN AGED 40 Edinburgh?Stockholm Study

1978 • 172 citations

IS THE LEVEL OF SERUM TRIGLYCERIDE A SIGNIFICANT PREDICTOR OF CORONARY DEATH IN “NORMOCHOLESTEROLEMIC” SUBJECTS?

1986 • 162 citations

Somatostatin inhibition of fructose-induced hypertension.

1989 • 157 citations

Attenuation of fructose-induced hypertension in rats by exercise training.

1988 • 153 citations

Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride

1985 • 141 citations

Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat

1982 • 135 citations

Abnormalities of Carbohydrate and Lipid Metabolism in Patients With Hypertension

1987 • 131 citations

Resistance to Insulin-Stimulated Glucose Uptake in Adipocytes Isolated From Spontaneously Hypertensive Rats

1989 • 126 citations

Plasma lipoprotein levels in treated and untreated hypertensive men and women. The National Heart Foundation of Australia Risk Factor Prevalence Study.

1985 • 124 citations

Sucrose-induced insulin resistance in the rat: modulation by exercise and diet

1983 • 113 citations

Relationship Between Blood Pressure, Plasma Insulin ana Triglyceride Concentration, and Insulin Action in Spontaneous Hypertensive and Wistar-Kyoto Rats

1991 • 98 citations

Effect of Differences in Glucose Tolerance on Insulin's Ability to Regulate Carbohydrate and Free Fatty Acid Metabolism in Obese Individuals*

1986 • 89 citations

Effect of Habitual Physical Activity on Regulation of Insulin‐stimulated Glucose Disposal in Older Males

1985 • 88 citations

Obesity and Hypertension

1982 • 84 citations

Evidence that multiple risk factors for coronary artery disease exist in persons with abnormal glucose tolerance

1987 • 75 citations

Disturbances of insulin in British Asian and white men surviving myocardial infarction.

1989 • 74 citations

Plasma lipid and lipoprotein concentrations in Chinese males with coronary artery disease, with and without hypertension

1987 • 66 citations

Ability of exercise to inhibit carbohydrate-induced hypertriglyceridemia in rats

1981 • 55 citations

Antihypertensive Effect of Insulin Reduction in Diabetic-Hypertensive Patients

1989 • 51 citations

How Insulin Resistant Are Patients with Noninsulin-Dependent Diabetes Mellitus?*

1985 • 45 citations

Inhibition of carbohydrate-induced hypertriglyceridemia by a disaccharidase inhibitor

1981 • 30 citations

THE CAUSES OF DEATH IN DIABETES MELLITUS

1963 • 19 citations

Coronary artery disease in Chinese males without hypercholesterolaemia

1990 • 7 citations

THE CAUSES OF DEATH IN DIABETES MELLITUS

1963 • 4 citations