Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs.

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Lysosomotropic agents

1974 • 1,887 citations

Statistical Quality Control and Routine Data Processing for Radioimmunoassays and Immunoradiometric Assays

1974 • 1,063 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.

1981 • 424 citations

Identification and characterization of a proton pump on lysosomes by fluorescein-isothiocyanate-dextran fluorescence.

1982 • 379 citations

Cationic Amphiphilic Drug-Induced Phospholipidosis

1997 • 343 citations

Reversal of Chloroquine Resistance in Malaria Parasite Plasmodium falciparum by Desipramine

1988 • 225 citations

The potential role of lysosomes in tissue distribution of weak bases

1988 • 200 citations

The hydrophobic adsorption of charged molecules to bilayer membranes: a test of the applicability of the Stern equation

1976 • 164 citations

The binding of drugs to different polar lipids in vitro

1979 • 121 citations

Measurement of intralysosomal pH

1973 • 114 citations

Contribution of Lysosomal Trapping to the Total Tissue Uptake of Psychotropic Drugs

1997 • 106 citations

Relationships in the structure-tissue distribution of basic drugs in the rabbit.

1990 • 69 citations

pKa Determination of Verapamil by Liquid-Liquid Partition

1984 • 66 citations

Micellar properties of phenothiazine drugs: A laser light scattering study

1985 • 63 citations

Chloroquine accumulation in isolated rat liver lysosomes

1976 • 58 citations

Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates.

1997 • 46 citations

Isolation of Highly Purified Lysosomes from Rat Liver: Identification of Electron Carrier Components on Lysosomal Membranes1

1991 • 42 citations

Gas chromatographic determination of amantadine hydrochloride (symmetrel) in human plasma and urine

1980 • 41 citations

Cellular accumulation of amiodarone and desethylamiodarone in cultured human cells

1993 • 38 citations

Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver.

1996 • 37 citations

[12] Use of fluorescein isothiocyanate-dextran to measure proton pumping in lysosomes and related organelles

1989 • 29 citations

Brain regional pharmacokinetics of biperiden in rats

1992 • 25 citations

Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats.

1990 • 24 citations

ATP-Dependent Uptake of Anti-Neoplastic Agents by Acidic Organelles1

1994 • 23 citations

Organic cation transport by rat liver lysosomes

1995 • 22 citations

Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells

1995 • 20 citations

Ionization and adsorption of a series of local anesthetics in detergent micelles: studies of drug fluorescence.

1994 • 18 citations

Influence of Ammonium Chloride on the Tissue Distribution of Anticholinergic Drugs in Rats

1998 • 15 citations

Lack of Pharmacokinetic Interaction Between Chloroquine and Imipramine

1993 • 15 citations

Gas chromatographic assay of atropine in formulations containing atropine sulphate and cholinesterase reactivators

1983 • 13 citations

Liquid membrane: Equilibrium potential distribution across lipid monolayer-coated oil/water interface

1985 • 11 citations

PHOTOPHYSICAL STUDIES OF LOCAL ANESTHETICS, TETRACAINE and PROCAINE: DRUG AGGREGATIONS

1990 • 11 citations

ATP-dependent Lysis of Isolated Lysosomes by Basic Substances and Acidic Ionophores.

1997 • 11 citations

Correlation of physicochemical properties with absorption and metabolism of some tricyclic drugs

1978 • 8 citations

Thermodynamics and mathematical modeling of the partitioning of chlorpromazine between n-octanol and aqueous buffer.

1990 • 3 citations