Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects.

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

Hyperuricemia in Primary and Renal Hypertension

1966 • 506 citations

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

1976 • 414 citations

Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.

1984 • 338 citations

Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat.

1975 • 336 citations

Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.

1990 • 314 citations

Control of glomerular filtration rate by renin-angiotensin system

1977 • 312 citations

Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation

1986 • 287 citations

Use of an Angiotensin II Antagonist (Saralasin) in the Recognition of “Angiotensinogenic” Hypertension

1975 • 279 citations

Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent.

1990 • 270 citations

Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

1991 • 249 citations

Tubular transport responses to angiotensin

1985 • 212 citations

Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent.

1990 • 203 citations

Renin- and non-renin–mediated antihypertensive actions of converting enzyme inhibitors

1984 • 200 citations

Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist

1992 • 182 citations

Sodium intake and renal responses to captopril in normal man and in essential hypertension

1981 • 177 citations

Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects

1992 • 174 citations

Angiotensin receptor subtypes of the kidney cortex

1987 • 169 citations

A Modification of the Diphenylamine Method for Determination of Inulin

1942 • 154 citations

Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers.

1987 • 129 citations

Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium, and phosphate

1973 • 116 citations

Proximal nephron and renal effects of DuP 753, a nonpeptide angiotensin II receptor antagonist

1990 • 116 citations

Therapeutic implications of hypertension-induced glomerular injury: Comparison of enalapril and a combination of hydralazine, reserpine, and hydrochlorothiazide in an experimental model

1985 • 111 citations

Stimulation of renal sodium reabsorption by angiotensin II

1977 • 103 citations

Localization and Properties of Angiotensin Receptors

1985 • 98 citations

Regulation of papillary plasma flow by angiotensin II

1987 • 87 citations

Osmolality, bicarbonate concentration, and water reabsorption in proximal tubule of the dog nephron

1963 • 85 citations

Chronic blockade of angiotensin II formation during sodium deprivation

1979 • 81 citations

Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

1991 • 79 citations

Highly sensitive microassay for aldosterone in unextracted plasma: comparison with two other methods.

1984 • 53 citations

The role of endogenous angiotensin II in the regulation of renal haemodynamics and proximal fluid reabsorption in the rat.

1992 • 50 citations

Effects of the Nonpeptide Angiotensin II Receptor Antagonist DuP 753 on Blood Pressure and Renal Functions in Spontaneously Hypertensive PH Dogs

1991 • 50 citations

THE CLEARANCE OF INULIN AND SODIUM P-AMINOHIPPURATE IN THE RAT

1947 • 43 citations

Effects of DuP 753 on Renal Function of Normotensive and Spontaneously Hypertensive Rats

1991 • 41 citations

Renal-Specific Actions of Angiotensin II Receptor Antagonism in the Anesthetized Dog

1992 • 39 citations

Acute reversal by saralasin of multiple intrarenal effects of angiotensin II

1979 • 39 citations

109. Efficacy and safety of oral MK-954 (DuP 753), an angiotensin receptor antagonist, in essential hypertension

1991 • 38 citations

Angiotensin II blockade in normal man: Interaction of renin and sodium in maintaining blood pressure

1977 • 35 citations

Interactive effects of angiotensin II on renal hemodynamics and tubular reabsorptive function.

1990 • 33 citations

Analysis of renal denervation in the hydropenic rat: interactions with angiotensin II

1984 • 33 citations

Angiotensin II measurement with high-affinity monoclonal antibodies

1988 • 25 citations

DuP 753 Is a Potent Nonpeptide Antagonist of Angiotensin II Receptors in Isolated Perfused Rat Kidney and Cultured Renal Cells

1991 • 24 citations

In Vitro Effects of DuP 753, a Nonpeptide Angiotensin II Receptor Antagonist, on Human Platelets and Rat Vascular Smooth Muscle Cells

1991 • 23 citations

Effects of renal arterial angiotensin I infusion on glomerular dynamics in sodium replete dogs

1984 • 19 citations

Effects of repeated doses of enalapril on renal function in man.

1985 • 18 citations

Glomerular and tubular antinatriuretic actions of low-dose angiotensin II infusion in man

1992 • 15 citations

Lithium clearance derived from the natural trace blood and urine lithium levels.

1990 • 12 citations

109. Efficacy and safety of oral MK-954 (DuP 753), an angiotensin receptor antagonist, in essential hypertension

1991 • 10 citations

Lithium clearance derived from the natural trace blood and urine lithium levels.

1990 • 10 citations

Repeated Administration of the Converting Enzyme Inhibitor Cilazapril to Normal Volunteers

1987 • 9 citations