Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.

Genetic instabilities in human cancers

1998 • 4,165 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Clonal Genetic Alterations in the Lungs of Current and Former Smokers

1997 • 462 citations

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

1999 • 349 citations

Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

1994 • 322 citations

Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung.

1997 • 261 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Cigarette smoke induces DNA single-strand breaks in human cells

1985 • 248 citations

Implications and Prognostic Value of K-ras Mutation for Early-Stage Lung Cancer in Women

1999 • 229 citations

K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.

1996 • 216 citations

Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types

1998 • 195 citations

K‐ ras oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 187 citations

Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.

1994 • 161 citations

Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma.

1994 • 146 citations

Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer.

2000 • 136 citations

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

1999 • 131 citations

Smoking and cancer

1992 • 117 citations

Benzo(a)pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer.

1996 • 116 citations

Molecular Changes in the Bronchial Epithelium of Patients with Small Cell Lung Cancer

2000 • 112 citations

Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos.

1998 • 104 citations

Sequential molecular genetic changes in lung cancer development

1996 • 96 citations

p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells.

2000 • 94 citations

Meta-analyses of p53 tumor suppressor gene alterations and clinicopathological features in resected lung cancers.

1999 • 92 citations

Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers.

2001 • 73 citations

p53 alterations in atypical alveolar hyperplasia of the human lung

1998 • 70 citations

A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients

1996 • 56 citations

Alcoholic Beverage Consumption and Lung Cancer Risk among Residents of Los Angeles County

1998 • 52 citations

Immunohistochemical and molecular evaluation of the mdm-2 gene product in bronchogenic carcinoma

1996 • 20 citations

Individuals at high risk for lung cancer have airway epithelial cells with chromosome aberrations frequently found in lung tumor cells.

1998 • 17 citations

Occupational Lung Cancer

1993 • 12 citations