Synthesis and properties of oligodeoxynucleotides containing the analogue 2′-deoxy-4′-thiothemidine

Polymer support oligonucleotide synthesis XVIII^1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

1984 • 840 citations

The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.

1993 • 437 citations

Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

1991 • 170 citations

Effects of functional group changes in the EcoRI recognition site on the cleavage reaction catalyzed by the endonuclease

1987 • 169 citations

The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogs

1991 • 143 citations

EcoRV restriction endonuclease binds all DNA sequences with equal affinity

1991 • 139 citations

Characterization of the genes coding for theEcoRV restriction and modification system ofEscherichia coli

1984 • 135 citations

Discrimination between DNA sequences by the EcoRV restriction endonuclease

1989 • 124 citations

Synthesis and properties of oligonucleotides containing 4-thiothyniidine, 5-methyl-2-pyrunidinone-1-β-D(2'-dexoyriboside) and 2-thiothvmidine

1989 • 104 citations

Incorporation of a complete set of deoxyadenosine and thymidine analogs suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase

1990 • 88 citations

Palindromic oiigonucleotides containing 7-deaza-2' -deoxyguanosine: solid-phasesynthesisof d[(p)GG*AATTCC] octamers and recognition by the endodeoxyribonncleaseEcoRI

1986 • 70 citations

Purification and crystallization of the EcoRV restriction endonuclease.

1985 • 67 citations

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability

1992 • 63 citations

The effects of base analogue substitutions on the methylation by the EcoRI modification methylase of octadeoxyribonucleotides containing modified EcoRI recognition sequences.

1986 • 60 citations

4′-Thio-oligo-β-D-ribonucleotides: synthesis of β-4′-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase

1993 • 50 citations

Interaction of the HpaI endonuclease with synthetic oligonucleotides

1982 • 47 citations

Sugar modified oligonucleotides I. Carbo-oligodeoxynucleotides as potential antisense agents

1989 • 46 citations

Overproduction of theEcoR V endonuclease and methylase

1985 • 42 citations

Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of α- and β-L-octathymidylates

1990 • 38 citations

The activity of the EcoRV restriction endonuclease is influenced by flanking DNA sequences both inside and outside the DNA-protein complex

1992 • 36 citations

DNA functional groups required for formation of open complexes between Escherichia coli RNA polymerase and the lambda PR promoter. Identification via base analog substitutions.

1987 • 35 citations

The cloning, purification and characterization of theEcoRV modification methylase

1988 • 35 citations

Continuous spectrophotometric assay for restriction endonucleases using synthetic oligodeoxynucleotides and based on the hyperchromic effect

1992 • 34 citations

Biochemical properties of oligo[(+)]-carbocyclic-thymidylates] and their complexes

1990 • 30 citations

Studies on gene control regions. III. Binding of synthetic and modified synthetic lac operator DNAs to lactose repressor

1977 • 30 citations

Synthesis and restriction enzyme analysis of oligodeoxyribonucleotides containing the anti-cancer drug 2', 2'-difluoro-2'-deoxycytidine

1992 • 16 citations