Increase in the frequency of p16INK4 gene inactivation by hypermethylation in lung cancer during the process of metastasis and its relation to the status of p53.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer

1996 • 547 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

Mutation and altered expression of p16^ in human cancer

1994 • 234 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

Mutations in the p16(INK4)/MTS1/CDKN2, p15(INK4B)/MTS2, and p18 genes in primary and metastatic lung cancer

1995 • 208 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

1997 • 197 citations

Mechanisms of p16INK4A inactivation in non small-cell lung cancers

1998 • 164 citations

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

1999 • 131 citations

Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers.

1999 • 107 citations

Expression of p16INK4a/p16α and p19ARF/p16β is frequently altered in non-small cell lung cancer and correlates with p53 overexpression

1998 • 106 citations

Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas

1998 • 105 citations

Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions.

1999 • 93 citations

FHIT mutations in human primary gastric cancer.

1997 • 91 citations

Correlation between methylation status of thep16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers

1998 • 86 citations

Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma

1995 • 80 citations

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.

1998 • 76 citations

Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage

1996 • 66 citations

Association ofCDKN2A (p16)/CDKN2B (p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma

1998 • 60 citations

Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia

1997 • 57 citations

Intragenic mutations of the p16 ^INK4 , p15 ^INK4B and p18 genes in primary non‐small‐cell lung cancers

1996 • 51 citations

Hypermethylation of p15/ink4b/MTS2 gene is differentially implicated among non-Hodgkin’s lymphomas

1998 • 42 citations

Molecular analysis of the cyclin-dependent kinase inhibitor genesp15INK4b/MTS21,p16INK4/MTS1,p18 andpl9 in human cancer cell lines

1996 • 40 citations

p16 inactivation in small-sized lung adenocarcinoma: Its association with poor prognosis

1999 • 40 citations

hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors

1998 • 37 citations

Stability of p53 tumor suppressor gene mutations during the process of metastasis and during chemotherapy

1996 • 7 citations