Metabolism of Hydralazine

Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable Pathogenesis

1976 • 513 citations

Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis

1973 • 322 citations

The Pharmacological Basis of Therapeutics. 9th ed

1997 • 311 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

HUMAN ACETYLATION POLYMORPHISM.

1964 • 301 citations

Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic Blockade

1972 • 274 citations

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

1970 • 257 citations

CLINICAL AND EXPERIMENTAL STUDIES ON THE HYDRALAZINE SYNDROME AND ITS RELATIONSHIP TO SYSTEMIC LUPUS ERYTHEMATOSUS

1967 • 207 citations

Mitochondrial Monoamine Oxidase

1968 • 173 citations

The Hemodynamic Effects of Hypotensive Drugs in Man

1953 • 160 citations

Relation of hydralazine plasma concentration to dosage and hypotensive action

1972 • 153 citations

Hydralazine elimination in man

1973 • 133 citations

Hydrazinderivate der Phtalazin‐ und Pyridazinreihe

1951 • 125 citations

CARDIOVASCULAR AND RENAL ADJUSTMENTS TO A HYPOTENSIVE AGENT

1952 • 117 citations

Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter

1950 • 116 citations

STUDIES ON HYDRALAZINE; EVIDENCE FOR A PERIPHERAL SITE OF ACTION 1

1954 • 99 citations

Renal Hyperemia Induced in Man by a New Phthalazine Derivative

1950 • 91 citations

Pyridoxine-Deficiency Neuropathy Due to Hydralazine

1965 • 86 citations

Collagen Biosynthesis in Blood Vessels of Brain and Other Tissues of the Hypertensive Rat

1975 • 78 citations

A Paradoxical Cerebral Hemodynamic Effect of Hydralazine

1975 • 76 citations

Duration of hydralazine action in hypertension

1975 • 76 citations

The determination of hydralazine in plasma by gas-liquid chromatography

1975 • 60 citations

Hypotensive Hydrazinophthalazines and Related Compounds

1959 • 59 citations

Determination of hydralazine and its metabolites by gas chromatography-mass spectrometry

1976 • 57 citations

Metabolism of Hydrazine Derivatives of Pharmacologic Interest

1972 • 55 citations

Radioautographic Localization of Hydralazine-1-C14 in Arterial Walls.

1966 • 53 citations

Studies on hydralazine

1976 • 53 citations

Metabolism and disposition of hydralazine-14C in man and dog.

1974 • 50 citations

Fluorometric determination of isonicotinic acid hydrazide in serum.

1967 • 47 citations

EVALUATION OF 1-HYDRAZINOPHTHALAZINE ("APRESOLINE") IN TREATMENT OF HYPERTENSIVE DISEASE

1952 • 47 citations

PURIFICATION AND PROPERTIES OF N‐ACETYLTRANSFERASE FROM MAMMALIAN LIVER

1968 • 46 citations

The interaction of lupus-inducing drugs with deoxyribonucleic acid

1974 • 45 citations

Studies on hydralazine

1976 • 44 citations

ACETYLATOR PHENOTYPE AND THE ANTIHYPERTENSIVE RESPONSE TO HYDRALAZINE

1975 • 40 citations

Disposition of Hydralazine in Man and a Specific Method for Its Determination in Biological Fluids

1974 • 40 citations

Plasma levels of real and "apparent" hydralazine in man and rat.

1977 • 39 citations

1,214-Triazoles. XXII. Derivatives of the s-triazolo [3,4-alpha] phthalazine and related ring systems

1969 • 38 citations

The Effect of Intense Treatment with Hypotensive Drugs on Structural Design of the Resistance Vessels in Spontaneously Hypertensive Rats

1971 • 35 citations

Inhibition of monoamine oxidase by substituted hydrazines

1972 • 35 citations

Hydralazine-induced disturbances in collagen biosynthesis

1972 • 35 citations

INHIBITION OF DRUG-METABOLIZING ENZYMES OF LIVER MICROSOMES BY HYDRAZINE DERIVATIVES IN RELATION TO THEIR LIPID SOLUBILITY

1969 • 34 citations

THE METABOLISM OF 1-HYDRAZINOPHTHALAZINE.

1964 • 33 citations

Identification of two metabolites of hydralazine from human urine

1974 • 31 citations

Hemmung der Diaminooxydase (Histaminase) durch Phthalazinderivate

1952 • 30 citations

Liquid Chromatography in Pharmaceutical Analysis III: Separation of Diuretic‐Antihypertensive Mixtures

1975 • 29 citations

Metabolic pathways and control mechanisms involved in the biosynthesis and turnover of collagen in normal and pathological connective tissues

1973 • 28 citations

In vitro acetylation of drugs by human blood cells.

1974 • 26 citations

Synthesis of condensed heterocyclic systems. VI. Ring closure reactions involving 1-hydrazinophthalazine

1975 • 25 citations

Kinetics of the oxidation of hydrazine by hydrogen peroxide, catalyzed by hydrated copper(II)

1976 • 25 citations

3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man

1975 • 25 citations

Fluorescence of hydralazine in concentrated sulfuric acid

1976 • 23 citations

Simultaneous automated determination of hydralazine hydrochloride, hydrochlorothiazide, and reserpine in single tablet formulations

1972 • 23 citations

The effect of 1-hydrazinophthalazine (C-5968) and related compounds on the cardiovascular system of dogs.

1951 • 23 citations

Prolongation of hexobarbital sleeping time and inhibition of hepatic drug metabolism by adrenergic blocking agents in mice

1965 • 22 citations

Monoamine oxidase inhibitors and other drugs as inhibitors of diamine oxidase from human placenta and pig kidney

1974 • 21 citations

TREATMENT OF HYPERTENSION WITH ORAL RESERPINE ALONE AND IN COMBINATION WITH HYDRALAZINE OR HEXAMETHONIUM

1955 • 21 citations

Einfluss von Hydrazin- und Guanylhydrazonderivaten auf die Aktivit�t der Monaminoxydase, Diaminoxydase, Dopadecarboxylase und Histidindecarboxylase

1955 • 20 citations

Hydralazine therapy in hypertensive patients with idiopathic systemic lupus erythematosus

1975 • 19 citations

Immunological studies of collagens modified by reaction with hydralazine

1972 • 19 citations

Effect of Treatment on Longevity in Spontaneously Hypertensive Rats

1975 • 18 citations

STUDIES ON THE CONTROL OF HYPERTENSION BY HYPHEX. IV. LEVELS OF THE AGENTS IN URINE AND BLOOD

1954 • 15 citations

Inhibition of Dopamine- -Hydroxylase by Hydralazine

1974 • 14 citations

Identification and Quantitation of Impurities in Dapsone Preparations

1975 • 13 citations

A Metabolite of 1-Hydrazinophthalazine (Hydralazine).

1959 • 13 citations

Entwicklung der Symbiontenorgane einer Kleinzikade (Euscelis plebejus Fall.) nach Ausschaltung der Symbionten

1969 • 12 citations

Conjoint clinic on drugs and genes

1965 • 11 citations

HYDRALAZINE‐INDUCED LUPOID SYNDROME

1974 • 11 citations

Reaktivität von Koordinationsverbindungen VIII. Zur Bildung von Eisen(II)‐Chelaten des Phtalazyl‐(1)‐hydrazyl‐Radikals

1962 • 9 citations

SHORT COMMUNICATION

1969 • 9 citations

Alteration of Renin Release by Stress and Adrenergic Receptor and Related Drugs in Unanesthetized Rats

1972 • 8 citations

Die Bedeutung der experimentellen Analyse f�r die therapeutische Anwendung blutdrucksenkender Pharmaka

1955 • 7 citations

Effect of Ring Substitution on the Hemolytic Action of Arylhydrazines

1974 • 7 citations

Occupational dermatitis from hydrazine hydrate used in boiler protection. Cross sensitization to apresoline, isoniazid and phenelzine.

1967 • 7 citations

Hydralazine urinary metabolites in systemic lupus erythematosus

1973 • 7 citations

Renal and Hemodynamic Effects of Combination Therapy in Hypertension

1974 • 6 citations

Effects of Transition Metals and of Metal-Binding Antihypertensive Agents on Tryptamine Oxidase and Dopa Decarboxylase

1969 • 6 citations

Inhibition of biologic acetylation by 1-hydrazinophthalazine.

1957 • 6 citations

Metabolism of Methylscopolammonium Methylsulfate (DD-234) in Rats

1974 • 5 citations

Acute and subacute toxicity of an adduct of hydralazine and a 3-ketoalkylthiazide

1965 • 5 citations

Phthalazines. VII. : On the Reaction of 1-(Methylsulfonyl)-phthalazine with Nucleophiles

1969 • 4 citations

Studied on <SUP>1</SUP>4C-Labelled N<SUB>1</SUB>-Carboethoxy-N<SUB>2</SUB>-Hydroazinophthalazine Hydrochloride (Apiracohl[○!R]). I.Synthesis of Labelled Compound and Metabolism in Rats

1973 • 4 citations

The metabolic fate of 1,4-dihydroxyphthalazine-1-14C

1964 • 4 citations

LD50 determination and hypotensive effect of 3-methyl-2-benzothiazolone hydrazone

1976 • 3 citations

Influence of Hydralazine on the Sulfhydryl Group in the Presence of Cupric Ion.

1965 • 3 citations

Some Effects of Hydrallazine on Blood Iron and an Iron-Containing Enzyme System

1959 • 3 citations

The formation of free radical intermediates from vitamin C and isoniazid or apresoline.

1975 • 3 citations

[Hydrazino-phthalazine and rhodan-phthalazine].

1955 • 2 citations

N–N bond fission and ring opening in s-triazolo[3,4-a]phthalazines

1968 • 1 citations