The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

The Disease Burden Associated With Overweight and Obesity

1999 • 5,006 citations

Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

1999 • 3,707 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

1999 • 2,051 citations

Annual Deaths Attributable to Obesity in the United States

1999 • 1,924 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Medical Hazards of Obesity

1993 • 1,428 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

Regional adiposity and morbidity.

1994 • 1,135 citations

Receptor-mediated regional sympathetic nerve activation by leptin.

1997 • 980 citations

Chronic Leptin Infusion Increases Arterial Pressure

1998 • 694 citations

The Effect of Weight Reduction on Blood Pressure, Plasma Renin Activity, and Plasma Aldosterone Levels in Obese Patients

1981 • 657 citations

The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents

1989 • 622 citations

Sympathetic Activation in Obese Normotensive Subjects

1995 • 609 citations

Dietary Sodium Intake and Subsequent Risk of Cardiovascular Disease in Overweight Adults

1999 • 508 citations

A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives

1997 • 490 citations

Pathophysiological role of leptin in obesity-related hypertension

2000 • 479 citations

Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

2000 • 467 citations

Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors

1992 • 427 citations

Regional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects

1997 • 403 citations

Neural mechanisms in human obesity-related hypertension

1999 • 394 citations

Angiotensinogen-deficient mice with hypotension.

1994 • 378 citations

Body Weight Reduction, Sympathetic Nerve Traffic, and Arterial Baroreflex in Obese Normotensive Humans

1998 • 360 citations

Sympathetic and Cardiorenal Actions of Leptin

1997 • 354 citations

Influence of Perivascular Adipose Tissue on Rat Aortic Smooth Muscle Responsiveness

1991 • 347 citations

Pivotal role of nitric oxide in the control of blood pressure after leptin administration.

1999 • 325 citations

Development of Hypertension in a Rat Model of Diet-Induced Obesity

2000 • 312 citations

Renal Denervation Attenuates the Sodium Retention and Hypertension Associated With Obesity

1995 • 307 citations

Haplotypes of Angiotensinogen in Essential Hypertension

1997 • 285 citations

Dissociation Between Muscle and Skin Sympathetic Nerve Activity in Essential Hypertension, Obesity, and Congestive Heart Failure

1998 • 252 citations

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

1995 • 245 citations

Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice

1999 • 245 citations

Visceral Obesity and Insulin Resistance Are Associated with Plasma Aldosterone Levels in Women

1999 • 222 citations

Mechanisms of Hypertension and Kidney Disease in Obesity

1999 • 213 citations

Mechanisms of Abnormal Renal Sodium Handling in Obesity Hypertension

1997 • 210 citations

Plasma atrial natriuretic peptide and natriuretic peptide receptor gene expression in adipose tissue of normotensive and hypertensive obese patients

1997 • 200 citations

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.

1994 • 197 citations

Association Between the Angiotensinogen 235T-Variant and Essential Hypertension in Whites

1997 • 195 citations

Obesity-Induced Hypertension

1999 • 191 citations

Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control

1997 • 179 citations

The Role of Salt in the Fall of Blood Pressure Accompanying Reduction in Obesity

1958 • 178 citations

Angiotensinogen Genotype, Sodium Reduction, Weight Loss, and Prevention of Hypertension

1998 • 172 citations

Obesity, the sympathetic nervous system, and essential hypertension.

1992 • 169 citations

Plasma Angiotensinogen Concentrations in Obese Patients

1997 • 169 citations

Blood pressure and hormone changes associated with weight reduction in the obese.

1982 • 165 citations

ACE, angiotensinogen and obesity: a potential pathway leading to hypertension

1997 • 165 citations

Atrial Natriuretic Peptide Inhibits Mitogen-activated Protein Kinase through the Clearance Receptor

1996 • 161 citations

Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity

1996 • 156 citations

Role of sympathetic nervous system and neuropeptides in obesity hypertension

2000 • 151 citations

Weight Gain–Induced Blood Pressure Elevation

2000 • 147 citations

Elevated Sympathetic Activity Contributes to Hypertension and Salt Sensitivity in Diabetic Obese Zucker Rats

2000 • 145 citations

Obesity and hypertension

1999 • 142 citations

Aldosterone in obesity

1998 • 137 citations

Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men

1998 • 137 citations

Obesity Is Associated With Tissue-Specific Activation of Renal Angiotensin-Converting Enzyme In Vivo

2000 • 124 citations

Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering.

1994 • 115 citations

Mechanisms contributing to angiotensin II regulation of body weight

1998 • 115 citations

The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity

2000 • 110 citations

ABNORMAL KIDNEY FUNCTION AS A CAUSE AND A CONSEQUENCE OF OBESITY HYPERTENSION

1998 • 108 citations

Salt-regulating hormones in young normotensive obese subjects. Effects of saline load.

1994 • 107 citations

Renal Sympathetic Nerve Activity Is Increased in Obese Zucker Rats

1995 • 105 citations

CARDIOVASCULAR CONSEQUENCES OF OBESITY: ROLE OF LEPTIN

1998 • 104 citations

INSULIN AS A VASCULAR HORMONE: IMPLICATIONS FOR THE PATHOPHYSIOLOGY OF CARDIOVASCULAR DISEASE

1998 • 102 citations

Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue

1995 • 101 citations

Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans

1999 • 101 citations

Is there a role for the ob gene product leptin in essential hypertension?

1998 • 99 citations

Central Obesity and Hypertension: Relationship Between Fasting Serum Insulin, Plasma Renin Activity, and Diastolic Blood Pressure in Young Obese Subjects

1994 • 96 citations

Renin, Aldosterone and Glucagon in the Natriuresis of Fasting

1975 • 96 citations

ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models

2000 • 93 citations

Renal effects of leptin in normotensive, hypertensive, and obese rats

1998 • 89 citations

A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives

1999 • 86 citations

The obese gene product, leptin

1998 • 85 citations

Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice

1998 • 78 citations

The natriuretic peptide system in obesity-related hypertension: new pathophysiological aspects.

1999 • 75 citations

Altered Pressure-Natriuresis in Obese Zucker Rats

1999 • 71 citations

Low Calorie Diet Enhances Renal, Hemodynamic, and Humoral Effects of Exogenous Atrial Natriuretic Peptide in Obese Hypertensives

1999 • 69 citations

Distribution of renal medullary hyaluronan in lean and obese rabbits

2000 • 66 citations

Obesity, Salt Intake, and Renal Perfusion in Healthy Humans

1998 • 57 citations

Plasma Leptin Levels Strongly Correlate with Plasma Renin Activity in Patients with Essential Hypertension

1999 • 57 citations

Genetic Variation on Chromosome 1 Associated With Variation in Body Fat Distribution in Men

1995 • 57 citations

Abnormal pressure natriuresis in the dog model of obesity-induced hypertension.

1994 • 56 citations

Insulin Down-Regulates Angiotensinogen Gene Expression and Angiotensinogen Secretion in Cultured Adipose Cells

1998 • 56 citations

Renal Denervation Prevents and Reverses Hyperinsulinemia-Induced Hypertension in Rats

1998 • 53 citations

Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats

1992 • 52 citations

Refeeding hypertension in dietary obesity

1988 • 50 citations

Consequences of weight cycling in obese spontaneously hypertensive rats

1996 • 49 citations

The haemodynamics of obesity: a theoretical analysis

1992 • 49 citations

High plasma leptin concentrations in hypertensive men but not in hypertensive women

1999 • 48 citations

Fasting insulin and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index

1999 • 48 citations

Comparative analysis of atrial natriuretic peptide receptor expression in rat tissues

1993 • 48 citations

The renin-angiotensin system in the type II diabetic obese Zucker rat.

1993 • 48 citations

Angiotensinogen Gene Polymorphism Near Transcription Start Site and Blood Pressure

1999 • 47 citations

Refeeding hypertension in obese spontaneously hypertensive rats.

1994 • 47 citations

Cardiovascular regulation in obesity-induced hypertension.

1992 • 45 citations

Metabolic syndrome and hypertension: pathophysiology and molecular basis of insulin resistance

1998 • 43 citations

Body Fat, Resting and Exercise Blood Pressure and the Angiotensinogen M235T Polymorphism: The Heritage Family Study

1999 • 39 citations

Heritability of Angiotensin-Converting Enzyme and Angiotensinogen

2000 • 39 citations

Role of angiotensin II in brown adipose thermogenesis during cold acclimation

1993 • 36 citations

Transforming growth factor alpha and atrial natriuretic peptide in white adipose tissue depots in rats

1992 • 35 citations

Sodium and Obesity in the Pathogenesis of Hypertension

1990 • 33 citations

EFFECTS OF INSULIN AND GLUCAGON ON PRODUCTION OF RENIN SUBSTRATE BY THE ISOLATED RAT LIVER

1980 • 32 citations

Localization of Atrial Natriuretic Factor Receptors in the Mesenteric Arterial Bed

1995 • 31 citations

Heredity and obesity-associated hypertension: impact of hormonal characteristics and left ventricular mass

1995 • 30 citations

Angiotensin II in brown adipose tissue from young and adult Zucker obese and lean rats

1994 • 25 citations

Blunted natriuretic response to an acute sodium load in obese hypertensive dogs.

1992 • 23 citations

Sodium balance and hypertension in obese and fatty rats.

1996 • 23 citations

Aldosterone Studies in Obese Patients with Hypertension

1985 • 22 citations

Effect of Experimental Obesity and Subsequent Weight Reduction upon Circulating Atrial Natriuretic Peptide

1989 • 22 citations

Dietary obesity and weight cycling in rats: a model of stress-induced hypertension?

1991 • 18 citations

Ambulatory blood pressure and neuroendocrine control after diet-assisted gastric restrictive surgery

2000 • 17 citations

The sympathoadrenal system, obesity and hypertension: An overview

1990 • 15 citations

Changes in blood pressure and in vasoactive and volume regulatory hormones during semistarvation in obese subjects

1998 • 13 citations

Acute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue

1994 • 8 citations

Effect of weight reduction on the renin-aldosterone axis.

1985 • 4 citations