Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain.

Molecular Cloning: A Laboratory Manual

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Molecular cloning: A laboratory manual

1990 • 85,659 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Evolution of Proteolytic Enzymes

1984 • 641 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Redesigning Trypsin: Alteration of Substrate Specificity

1985 • 357 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

[3] Cell-free translation of messenger RNA in a wheat germ system

1983 • 301 citations

The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases

1987 • 296 citations

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

1982 • 220 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

The Three-Dimensional Structure of Asn ¹⁰² Mutant of Trypsin: Role of Asp ¹⁰² in Serine Protease Catalysis

1987 • 212 citations

Kringles: modules specialized for protein binding

1984 • 185 citations

An investigation into the minimum requirements for peptide hydrolysis by mutation of the catalytic triad of trypsin

1992 • 161 citations

Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin

1987 • 158 citations

A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease

1986 • 148 citations

The dorsal protein is distributed in a gradient in early drosophila embryos

1988 • 137 citations

Three-dimensional structure of the kringle sequence: structure of prothrombin fragment 1

1986 • 124 citations

Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity

1992 • 112 citations

A gene family inDrosophila melanogastercoding for trypsin-like enzymes

1985 • 95 citations

Model for haptoglobin heavy chain based upon structural homology.

1980 • 92 citations

Activation of the easter zymogen is regulated by five other genes to define dorsal-ventral polarity in the Drosophila embryo

1992 • 84 citations

Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site.

1993 • 71 citations

Studies on Limulus amoebocyte lysate. Isolation of pro-clotting enzyme.

1977 • 63 citations

A common domain within the proenzyme regions of the drosophila snake and easter proteins and tachypleus proclotting enzyme defines a new subfamily of serine proteases

1992 • 58 citations

Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain

1990 • 54 citations

The Structures of Domains of Blood Proteins

1991 • 45 citations

Assembly of the Prothrombinase Complex

1982 • 43 citations

An alternate geometry for the catalytic triad of serine proteases

1992 • 38 citations

The Molecular Basis of Blood Coagulation

2017 • 34 citations

Cofactor Proteins In The Assembly And Expression Of Blood Clotting Enzyme Complexes

1988 • 25 citations

Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP.

1989 • 24 citations

Establishment of dorsal-ventral and terminal pattern in the Drosophila embryo

1991 • 19 citations